DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and Appl2

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001102211.1	Gene:	Appl2 / 362860	RGDID:	1563028	Length:	662	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	68/306 - (22%)
Similarity:	119/306 - (38%)	Gaps:	66/306 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 AVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQL-------- 307
            |||:|       ||:..|::.|:   |..|::.|||.|.  .:|....:|.|.::::
  Rat     3 AVDKL-------LLEEALQDSPQ---TRSLLSVFEEDAG--TLTDYTNQLLQAMQRVYGAQNEMC 55

  Fly   308 ---PKCNRTLLAW---------------VLLHFDAVIQQE---RHNKLNAQSLAMLLSPTLQMSH 351
               .:.:|.|||:               ..||:.:.:..|   .|::|..|....::.|.:|...
  Rat    56 LATQQLSRQLLAYEKQNFALGKGDEEVISTLHYFSKVMDELNGLHSELAKQLADTMVLPVIQFRE 120

  Fly   352 RLM--VALLCHCNNLFA------DVQLIKY--VPPLTSTSPKLPDTPEDIQTELRKQDSLLSQIH 406
            :.:  |:.|   .:||.      |:.:.||  :|..........|..:::....|||.....|.:
  Rat   121 KDLTEVSTL---KDLFGLASNEHDLSMAKYSRLPKRKENERVKTDVAKEVAAARRKQHLSSLQYY 182

  Fly   407 SEMNAGFITKKREEQLWEVQRIITQLKRKLRTFEKKQEKTAEEVDN-SSSAPPAVASEDTTDSKP 470
            ..:|| ...:||...:   :.:|.....::..|:|..|..::.:|. .||....|.|........
  Rat   183 CALNA-LQYRKRAAMM---EPLIGFAHGQINFFKKGAEMFSKSMDGFLSSVTDMVQSIQVELEAE 243

  Fly   471 AGTPAVSTNNSISQEE----PKTDTLTPKDAPNDFTIDPSTGFILL 512
            |....||....:|..|    |..|..||:...|   :...||::.|
  Rat   244 ADKMRVSQQELLSVSESVYTPDIDVATPQINRN---LIQKTGYLNL 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	33/153 (22%)
Appl2	NP_001102211.1	BAR_APPL2	20..234	CDD:153316	44/222 (20%)
		BAR-PH_APPL	252..376	CDD:270067	10/38 (26%)
		PTB_APPL	480..613	CDD:269980
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910