Protein Alignment Rlip and Arhgap35

DIOPT Version :9

• Sequence 1: NP_650933.2
• Gene: Rlip / 42484
• FlyBaseID: FBgn0026056
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001258061.1
• Gene: Arhgap35 / 306400
• RGDID: 1308738
• Length: 1499
• Species: Rattus norvegicus
• Alignment Length: 459
• Identity: 100/459 - (21%)
• Similarity: 192/459 - (41%)
• Gaps: 96/459 - (20%)

  Fly     6 PEEKEFPGLYASEAADAKSR-KSKEESDFSEDHDHSKKDLLIGRRKDK-KEKGKDRGYAALEGES 68
            |::...|..|| |..||..: :::||:.:|..||.::..::..|..:| :..|...|
  Rat  1078 PQDGFDPSDYA-EPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNG-------- 1133

  Fly    69 SPEEELDTKSPSKSKK----SKTFKFTSSKSKEKREKSRDKSEKDSKHAEEEPSVSHKVKEKERD 129
             .:.|:||.|..:.:|    ||...:.:..::..|..|...|.......|..|     :::||.|
  Rat  1134 -SDSEMDTSSLERGRKVSAVSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGP-----IRKKEED 1192

  Fly   130 ------KEKDRDEPKKKDKEEKRKEKDKKADKKDKKDKKSKQLSQQQDDVSAAEEVLALGYPVFG 188
                  |..:...|.:.|::.:|:...:...:..||.|...:       .|..:......|  ||
  Rat  1193 QASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPR-------PSITKATWESNY--FG 1248

  Fly   189 VSVSLATERSRCHDGVDIPLVVRDCIDFLQ-DHLKCEQIYKIEPIKTRLMHFKRLYNNREH--DS 250
            |.::......:     .||:.:..||:::: ..|..|.||::...|:.:...:|.: :::|  |.
  Rat  1249 VPLTTVVTPEK-----PIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQF-DQDHNLDL 1307

  Fly   251 AVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAE---LQQLLEQLPKCNR 312
            |..:..:.|....:|.|..|||:||:...:  :.:.|.:| |:..::.:   |:::|::.||.|.
  Rat  1308 AEKDFTVNTVAGAMKSFFSELPDPLVPYSM--QIDLVEAH-KINDREQKLHALKEVLKKFPKENH 1369

  Fly   313 TLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQ-------------MSHRLMVAL-LCHCNN 363
            .:..:|:.|.:.|....:.|.:.:::|::...|||.             .|::.::.| :..|..
  Rat  1370 EVFKYVISHLNRVSHNNKVNLMTSENLSICFWPTLMRPDFSSMDALTATRSYQTIIELFIQQCPF 1434

  Fly   364 LF--------------ADVQLIKYVPPLTST----------SPKLPDTPEDIQTELRKQDSLLSQ 404
            .|              :...:...||.||||          ||  |.||:.     ..|..|.||
  Rat  1435 FFYNRPISEPPGAAPGSPSAMAPTVPFLTSTPATSQPSPPQSP--PPTPQS-----PMQPLLSSQ 1492

  Fly   405 IHSE 408
            :.:|
  Rat  1493 LQAE 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	44/214 (21%)
Arhgap35	NP_001258061.1	Has GTPase activity, required for proper localization. /evidence=ECO:0000250|UniProtKB:Q91YM2	1..266
		RAS	<158..250	CDD:214541
		RhoGAP-FF1	261..340	CDD:406821
		FF	371..422	CDD:128718
		FF	431..483	CDD:128718
		FF	486..539	CDD:128718
		pseudoGTPaseD_p190RhoGAP-A	594..765	CDD:412066
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1124..1148		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1177..1212		8/39 (21%)
		Required for phospholipid binding and regulation of the substrate preference. /evidence=ECO:0000250|UniProtKB:Q9NRY4	1213..1236		4/29 (14%)
		RhoGAP_p190	1247..1431	CDD:239838	42/192 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1446..1499		16/58 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910