DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and AgaP_AGAP003146

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_312836.5	Gene:	AgaP_AGAP003146 / 1273818	VectorBaseID:	AGAP003146	Length:	658	Species:	Anopheles gambiae

Alignment Length:	683	Identity:	358/683 - (52%)
Similarity:	460/683 - (67%)	Gaps:	85/683 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDSPE--EKEFPGLYASEAADAKSRKSKEESDFSEDHDH--SKKDLLIGRRKDKKEKGKDRGY 61
            ||||||:  ||:|||||.|   ||..:..|::.|||:....  |||:|||||||||||  |...|
Mosquito     1 MDFDSPDCVEKDFPGLYGS---DASGKSKKDDKDFSDADPEKVSKKELLIGRRKDKKE--KKTAY 60

  Fly    62 AALEGESSPEEELDTKSPSKSKKSKTFKFTSSKSKEKREKSRDKSEKDSKHAEEEPSVSHKVKEK 126
            |.|||||||||||:||||||:|||||||| .|||||||||||:|.::..:.:::|.||  |..||
Mosquito    61 ATLEGESSPEEELETKSPSKTKKSKTFKF-PSKSKEKREKSREKDKERPETSKQEESV--KPPEK 122

  Fly   127 ERDKEKDRDEPKKKDKEEKRKEKDKKADKKDKKDKKSKQLSQQQDDVSAAEEVLALG--YPVFGV 189
             .:||||    ||||||  :|||:||...||||:||.||       .|.:||||.||  .|:|||
Mosquito   123 -GEKEKD----KKKDKE--KKEKEKKEKSKDKKEKKLKQ-------GSVSEEVLELGDAQPIFGV 173

  Fly   190 SVSLATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLYNNREHDSAVD 253
            |:.|||||||||||:::|||||||||:||:| |:.|||||:|.:||:|...||.||||| .|...
Mosquito   174 SLGLATERSRCHDGINLPLVVRDCIDYLQEHGLQSEQIYKVEAVKTKLQQLKRTYNNRE-GSCSG 237

  Fly   254 ELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWV 318
            |:::|.||.|||:||||||||:|||||.:||||||||.:|:.|:.||..|:||||.||||||:|:
Mosquito   238 EMDVPIACGLLKMFLRELPEPILTTDLSSRFEEVASHSQVSQQEQELVCLVEQLPSCNRTLLSWM 302

  Fly   319 LLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKYVPPLTSTSPK 383
            .:|.|||.|.|...|:|||::||||||||||||||.||:||||:.||||..|.|||||:|::||.
Mosquito   303 FMHVDAVTQNEDFTKMNAQNIAMLLSPTLQMSHRLFVAILCHCSTLFADTILHKYVPPITASSPN 367

  Fly   384 LPDTPEDIQTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFEKKQEKTAE 448
            ||:|||:|.||||||:|||:|||:||||||:|||||||||||||||||||||||:||||.:...:
Mosquito   368 LPETPEEISTELRKQESLLAQIHAEMNAGFVTKKREEQLWEVQRIITQLKRKLRSFEKKSDCVQK 432

  Fly   449 EVDNSSSAPPAV----------ASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTP--------- 494
            .:|::.....::          .|:|.:..|.  ..|:||.::.:.|...|...||
Mosquito   433 SLDDTVDGDISIDLNLQKAKLSCSDDESSIKT--VTAISTESATNTEAKNTPQETPDETGPAERK 495

  Fly   495 ----------------------------KDAP---NDFTIDPSTGFILLPKSNPHRENLLRLQIE 528
                                        .:||   :|.......||:|||:::|....|:|||:|
Mosquito   496 LSIADSPDTAMATAVGKADGTAAGQPITSEAPVPVSDKVTVTDNGFLLLPQNHPEYLTLIRLQLE 560

  Fly   529 YDELMEWQNELKARIVAERNEVYRLKQLYEQQS-INSQMASLASGSQAPPESDYERIIEHYTREN 592
            ..||:.|:.:|:|||..||||:.::|:|..... ..:..|||.:...|..|  |::::.||.:||
Mosquito   561 NQELVNWKAQLQARIQTERNEIVKMKKLLVADGCATNAPASLDASLTASEE--YDKLMAHYVKEN 623

  Fly   593 ALLEHKKNMLGMELKEERRACIALQVELRLQQF 625
            ||||.|:.||..|:.||.:..|.:||||.|.::
Mosquito   624 ALLEQKRQMLAKEIFEENKNLIQMQVELALNRY 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	122/181 (67%)
AgaP_AGAP003146	XP_312836.5	RhoGAP	171..351	CDD:295372	121/180 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	237	1.000	Domainoid score	I5222
eggNOG	1	0.900	-	-		E1_KOG4370
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136710
Inparanoid	1	1.050	618	1.000	Inparanoid score	I2303
OMA	1	1.010	-	-		QHG49463
OrthoDB	1	1.010	-	-		D514124at2759
OrthoFinder	1	1.000	-	-		FOG0005056
OrthoInspector	1	1.000	-	-		oto109578
Panther	1	1.100	-	-	LDO	PTHR12783
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.940