DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and AgaP_AGAP000563

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_310516.5	Gene:	AgaP_AGAP000563 / 1271660	VectorBaseID:	AGAP000563	Length:	983	Species:	Anopheles gambiae

Alignment Length:	407	Identity:	89/407 - (21%)
Similarity:	131/407 - (32%)	Gaps:	139/407 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GKDRGYAALEGESSPEEELDTKSPSKSKKSKTFKFTSSKSKEK--REKSRDKSEKDSKHAEEEPS 118
            |...|.||    :.||   |:.:.|.|...|:....|||..||  .:|.|.:|.:........|.
Mosquito   590 GLGSGAAA----AGPE---DSSTSSSSLSFKSLGADSSKFPEKWSIKKLRRRSYRQLLRRTNAPR 647

  Fly   119 VSHK------VKEKERDKEKDR-----------------DEPKKKDKEE-------KRKEKDKKA 153
            ....      |:|:|.::|.|.                 .||.:::.||       ...:....|
Mosquito   648 KGGSGGGGGVVQEQEEEEEGDEAYEQASSRLPVTDLDGDSEPDEEEGEEGEGAGGASGAKSCPDA 712

  Fly   154 DKKDKKDKKSKQ-------------------------LSQQQDDVSAAE----------EVLALG 183
            |:||...:..||                         |:..|:..|..|          |.|:..
Mosquito   713 DEKDVLARVPKQFADILLIGDNILTDDHNLPDEDLLLLNSDQESTSGEEDNAIMECEELERLSPN 777

  Fly   184 Y-----------PVFGVSVSLATERS--RCHDGVDIPL-------VVRDCIDFL---------QD 219
            |           ||...:::|..::|  ..||....||       .|..| :||         .|
Mosquito   778 YLLYKAASGHNLPVMSQALALGADKSWANPHDADRTPLHAAILSGSVMSC-EFLLLNGAAINATD 841

  Fly   220 -------HLKCEQIYKIEPIKTRLMHFKRLYN------NREHDSAVDELNLPTACSLLKLFL--- 268
                   ||..||....:..  .|:..|..|:      .|..|.||::.:.... :||:|.|
Mosquito   842 RYGRTPLHLAAEQGSAAQAY--LLLKHKARYDIADVDGRRPIDVAVEKEDADIV-TLLRLTLLND 903

  Fly   269 ----RELPEPLLTTD-----LVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLH--- 321
                .|..|.....|     ::..|..:||:.....|:...||..:|..:..:.|.|....|
Mosquito   904 EIGSGEDGEAYAGGDSTYVAVMNEFSHLASNQPQRLQRNRHQQQQQQQQQQRQALAATDDSHPLD 968

  Fly   322 FDAVIQQERHNKLNAQS 338
            .||..|.    |.||.|
Mosquito   969 LDATSQA----KSNAVS 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	46/198 (23%)
AgaP_AGAP000563	XP_310516.5	BAR_3	6..239	CDD:293351
		PH	304..397	CDD:278594
		PH_ACAP	305..400	CDD:270070
		ArfGap	469..585	CDD:279720
		ANK	777..896	CDD:238125	25/122 (20%)
		Ank_2	780..874	CDD:289560	20/96 (21%)
		ANK repeat	780..806	CDD:293786	4/25 (16%)
		ANK repeat	812..841	CDD:293786	6/29 (21%)
		ANK repeat	843..874	CDD:293786	7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910