DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and CHN1

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001358443.1	Gene:	CHN1 / 1123	HGNCID:	1943	Length:	476	Species:	Homo sapiens

Alignment Length:	164	Identity:	52/164 - (31%)
Similarity:	81/164 - (49%)	Gaps:	20/164 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 PLVVRDCIDFLQDH-LKCEQIYK-------IEPIKTRLMHFKRLYNNREHDSAV---DELNLPTA 260
            |:||..||..::.. |..|.:|:       ||.:|   |.|.|  :..:.|.:|   :::|:.|.
Human   299 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVK---MAFDR--DGEKADISVNMYEDINIITG 358

  Fly   261 CSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLHFDAV 325
            .  |||:.|:||.||:|.|...:|.|.|.......|...|.:.|:.||..:...|.:::.|...|
Human   359 A--LKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRV 421

  Fly   326 IQQERHNKLNAQSLAMLLSPTLQMSHRL--MVAL 357
            ...|:.|.:||::|.::..|||..|..|  |.||
Human   422 TLHEKENLMNAENLGIVFGPTLMRSPELDAMAAL 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	52/164 (32%)
CHN1	NP_001358443.1	SH2	67..145	CDD:387587
		C1_1	223..272	CDD:365894
		RhoGAP_chimaerin	283..476	CDD:239837	52/164 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910