DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and RALBP1

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_006779.1	Gene:	RALBP1 / 10928	HGNCID:	9841	Length:	655	Species:	Homo sapiens

Alignment Length:	649	Identity:	224/649 - (34%)
Similarity:	345/649 - (53%)	Gaps:	111/649 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SPEE---KEFPGLYASEAADAKSRKSKEESDF--SEDHDHSKKDLLIGRRKDKKEKGKDRGYAAL 64
            |.||   .:|||||.:...........|..|.  .::.||.||     :.|.||::.:..||||.
Human    29 SSEEISPTKFPGLYRTGEPSPPHDILHEPPDVVSDDEKDHGKK-----KGKFKKKEKRTEGYAAF 88

  Fly    65 EGESSPEEELDTKSPSKSKKSK---TFKFTS-SKSKEKREKSRDKSEKDSKHAEEEPSVSHKVKE 125
            :.:||.:|   .:||||.|:||   .||..| ||.|||..|.::| .|:.||.||
Human    89 QEDSSGDE---AESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEK-PKEEKHKEE---------- 139

  Fly   126 KERDKEKDRDEPKKKDKEEKRKEKDKK----AD-KKDKKDKKSKQLSQQQDDVSAAEEVLALGYP 185
                          |.||||.|||..|    || .|..|:||.|:...|:.:|... :|..| .|
Human   140 --------------KHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQI-DVPNL-KP 188

  Fly   186 VFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLYNNREHD 249
            :||:.::.|.||:..:||:.:|.|.|:|||:::.: :|||.||::..||:::...|..| :||..
Human   189 IFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAY-DREES 252

  Fly   250 SAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTL 314
            :.:::....|..||||.:||:|||.|||.:|:.||||.......|.:..|.|:||::||:||..|
Human   253 TNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLL 317

  Fly   315 LAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKYVPPL-- 377
            ::|:::|.|.||.:|...|:|.|:::::||||:|:|:|::.....|...||.:|.|.:.:.||
Human   318 ISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRW 382

  Fly   378 --TSTSPKLPDTPEDIQTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFE 440
              .:|.|.||:|...|:.|:|:|:.||:.:|.::..|.....:||:|||||||:|.||||||. .
Human   383 SNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLRE-A 446

  Fly   441 KKQE---KTAEEVDNSSSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTPKDAPNDFT 502
            |:||   |.|:|:       .:::.||                 :|:||..         .|:..
Human   447 KRQECETKIAQEI-------ASLSKED-----------------VSKEEMN---------ENEEV 478

  Fly   503 IDPSTGFILLPKSNPHRENLLRLQIEYDELMEWQNELKARIVAERNEVYRLK-QLYEQQS----- 561
            |:     |||.:.|       .:..|.:||:..:..|:.:|.:|:.|:.||: ::.|.||
Human   479 IN-----ILLAQEN-------EILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHG 531

  Fly   562 -INSQMASLASGSQAPPESDYERIIEHYTRENALLEHKKNMLGMELKEERRACIALQVELRLQQ 624
             ..::..|..|.|::..|.:.:.|:|...|:|..||.|.|.|...:.|||.|.|.|:|:|||.|
Human   532 RSETEEYSSESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQ 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	71/181 (39%)
RALBP1	NP_006779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..158		55/161 (34%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9PT60	102..119		7/16 (44%)
		Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000269\|PubMed:15610018	154..219		24/66 (36%)
		RhoGap_RalBP1	190..371	CDD:239846	71/181 (39%)
		SMC_N	<400..>627	CDD:330553	76/242 (31%)
		Mediates interaction with RALA and RALB. /evidence=ECO:0000269\|PubMed:20696399, ECO:0000269\|PubMed:7673236	403..499		42/141 (30%)
		Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000250\|UniProtKB:Q62796	500..655		33/96 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..551		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146913
Domainoid	1	1.000	122	1.000	Domainoid score	I5665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2750
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S4624
OMA	1	1.010	-	-		QHG49463
OrthoDB	1	1.010	-	-		D514124at2759
OrthoFinder	1	1.000	-	-		FOG0005056
OrthoInspector	1	1.000	-	-		oto90620
orthoMCL	1	0.900	-	-		OOG6_107500
Panther	1	1.100	-	-	LDO	PTHR12783
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4417
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.890