Protein Alignment Rlip and FAM13A

DIOPT Version :9

• Sequence 1: NP_650933.2
• Gene: Rlip / 42484
• FlyBaseID: FBgn0026056
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_055698.2
• Gene: FAM13A / 10144
• HGNCID: 19367
• Length: 1023
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 106/522 - (20%)
• Similarity: 202/522 - (38%)
• Gaps: 127/522 - (24%)

  Fly   155 KKDKKDKKSKQLSQQQDDVSAAEEVLALGY-PVFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQ 218
            |:|.|...:..|::|:|          ..| .:||||:.....:....:|  ||.||.:.:::|.
Human    18 KEDMKKIVAVPLNEQKD----------FTYQKLFGVSLQELERQGLTENG--IPAVVWNIVEYLT 70

  Fly   219 DH-LKCEQIYKIEPIKTRLMHFKRLYNNREHDSAVD-EL----NLPTACSLLKLFLRELPEPLLT 277
            .| |..|.::::.. ..:::...||    :.:|.|. ||    ::.:|.|||||||||||:.|:|
Human    71 QHGLTQEGLFRVNG-NVKVVEQLRL----KFESGVPVELGKDGDVCSAASLLKLFLRELPDSLIT 130

  Fly   278 TDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAML 342
            :.|..||.::....:...|::.|:.|:::||..:..||.::......|.:....|::|..:||.:
Human   131 SALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATV 195

  Fly   343 LSPTL-------------QMSHRLMVALLCHCNNLF---------------ADVQLIKYV----- 374
            ..|..             .:.:::|..:|.:.|.||               |.:.::|.|
Human   196 FGPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDHLRCENLARLIIVKEVYYKNS 260

  Fly   375 ----------------PPLTS---------------TSPKLPDTPEDIQTELRKQDSLLSQIHS- 407
                            ||.|.               ..|:|.|....:...|..:.:.|..::|
Human   261 LPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPELSDGIPQLSLRLSYRKACLEDMNSA 325

  Fly   408 --EMNAGFITKKREEQ-----------LWEVQRIITQLKRKLRTFEKKQEKTAEEVDNSSSAPPA 459
              .::|..:...:|::           :.:|..:....:...||.....|:...:|:||...
Human   326 EGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHLFDVNNSGGQ--- 387

  Fly   460 VASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTPKDAPNDFTIDPSTGFILLPKSN-PHRENLL 523
             :|||:.....:.:.|.|......|.:.:.:....:|..            |:.|.| |...|.|
Human   388 -SSEDSESGTLSASSATSARQRRRQSKEQDEVRHGRDKG------------LINKENTPSGFNHL 439

  Fly   524 RLQIEYDELMEWQNELKARIVAERNEVYR------LKQLYEQQS--INSQMASLASGSQAPPESD 580
            ...|...:.:|..::.......||::..|      |.:|::.|.  :|.:..:.....:.....|
Human   440 DDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDD 504

  Fly   581 YE 582
            :|
Human   505 FE 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	55/214 (26%)
FAM13A	NP_055698.2	RhoGAP_FAM13A1a	39..226	CDD:239858	51/193 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..290		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..437		14/71 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	459..562		9/48 (19%)
		HMMR_N	617..>819	CDD:292527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..663
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	726..759

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910