DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and arhgap28

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_002938100.2	Gene:	arhgap28 / 100488165	XenbaseID:	XB-GENE-1013085	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	117/535 - (21%)
Similarity:	204/535 - (38%)	Gaps:	100/535 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KKEKGKDRGYAALEG--ESSPEEELDTKSPSKSK------KSKTFKFTSSKSKEKREKSRDKSEK 108
            ||.|...|....:.|  :|:|..|..|.||..|.      |...:|..::.|....:.|...:|:
Frog   161 KKNKHTVRDVRDIFGINDSTPSFEPKTLSPIPSNGVQHMIKKPIWKPVTNNSCTLEKPSPSVAEE 225

  Fly   109 DSKHAEEEPSVSHKVKEKERDKEKDRDEPKKKDKE--------EKRKEKDKKADKKDKKDKKSKQ 165
            .|    .|.|.|..|....:|||.::::..|||..        :.|....:..|...:..||.:.
Frog   226 LS----FEASFSETVAVDGKDKESEKNQRIKKDDSALPKFIVWKSRFGLTEVGDLSLEDMKKIRY 286

  Fly   166 LSQQQDDVSAAEEVLALGYP-------------VFGVSVSLATER-SRCHDGVDIPLVVRDCIDF 216
            ||  ..:::|..:.|.:...             :|||.::...|. .:...|..:||:.:..:..
Frog   287 LS--LIELTAFYDALGIELKRNRIVRIKGKENGLFGVPLTTLLESDQKKFPGTKVPLIFQKLLQR 349

  Fly   217 LQD-HLKCEQIYKIEPIKTRLMHFKRLYNNREHDSAVD--ELNLPTACSLLKLFLRELPEPLLTT 278
            |:: .|:.|.|.::.....|:.:.:.....:.||::.|  ::....|..|||:|:||||.||.|.
Frog   350 LEETGLETEGILRVPGSAARVKNLREELEAKFHDNSFDWNKVRNNDAAGLLKMFIRELPSPLFTM 414

  Fly   279 DLVARF----EEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSL 339
            :.:..|    |:::   |:..|...|..|:..||..||.....:|.....|:..|..||::..::
Frog   415 EYLPAFITLVEKIS---KIKLQLQALHLLIMLLPDANRDTAKALLNFLKKVVSNEEKNKMSLWNV 476

  Fly   340 AMLLSPTLQMSHR--------LMVALLCHCNNLFADVQLIKYVPPLTSTSPKLPDTPEDIQTELR 396
            :|:|:|.|.:..|        ...|...|...|....|.|.:..|
Frog   477 SMILAPNLFICKRKSTNKEEMKAAASTAHIVRLLIRYQDILWTVP-------------------- 521

  Fly   397 KQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKL---RTFEKKQEKTAEEVD------- 451
              ..|:||:.....|..|..||       |.|..:..|:|   :|.|:::.:..|..|
Frog   522 --SFLISQVRKMNEAALINNKR-------QLIFDKSVRRLLRRKTMERERPERREHCDVPEGVIR 577

  Fly   452 ----NSSSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTPKDAP---NDFTIDPSTGF 509
                ..|....|:.....|.:|.........|:..:.:..:....:..:..   .:..:||.|..
Frog   578 VYAPLHSKVSMAIQLNSRTKAKDILARFHCENSHGTSDNVRIHNQSLYEIGGNIGEHCLDPDTYI 642

  Fly   510 ILLPKSNPHRENLLR 524
            :.:...|||.|.:|:
Frog   643 LDVYHVNPHAEWMLK 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	50/196 (26%)
arhgap28	XP_002938100.2	RhoGAP_ARHGAP18	318..529	CDD:239856	56/235 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910