DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and arhgap29

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001123763.2	Gene:	arhgap29 / 100170512	XenbaseID:	XB-GENE-964890	Length:	1348	Species:	Xenopus tropicalis

Alignment Length:	561	Identity:	125/561 - (22%)
Similarity:	214/561 - (38%)	Gaps:	123/561 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EDHDHSKKDLL--------------IG----RRKDKKEKGKDRGYAALEGESSPEEE-------- 73
            ||:.|:.:..|              ||    ||.:|.|:.:......:.|...|...
Frog   525 EDNAHASQGNLSQGSGEFPSQPPDDIGSPVYRRSNKMEQKRSSSSIDIPGMRGPPPFRSWSVGNQ 589

  Fly    74 -----LDTKSPSKSKKSKTFKFTS-SKSKEKREKSR-----DKSEKDSKHAEEEPSVSHK----- 122
                 .|::|...|.:|::....| |....||...|     ..|..|.....|.||.|..
Frog   590 SGGMCSDSESAGGSSESRSMDSPSASPGGFKRRLPRTPSTGTMSSADDLDEREPPSPSENGLNDL 654

  Fly   123 VKEKERDKEKDRDEPKKKDKEEKRKEKDKKADKKDKKDKKSKQLSQQQDDVSAA-----EEVLAL 182
            |.|........|:....|..:..:..|.:...|..:.|........:.::.|.|     .|.||:
Frog   655 VSEIANSPGPFRNTNMSKAAQTHKLRKLRAPSKCRECDSLVVFHGAECEECSLACHKKCLETLAI 719

  Fly   183 --GYP-------VFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLM 237
              |:.       :|||..:.|.:.:  |||  ||.:::.|...::.. |..:.||::...|:|:.
Frog   720 QCGHKKLHGRLHLFGVEFTQAAKNT--HDG--IPFIIKKCTTEIESRALTVKGIYRVNGAKSRVE 780

  Fly   238 HFKRLYNNREHDSAVDELNLPTACSLLKLFLRELPEPL----LTTDLVARFEEV----------A 288
            ...:.:.|.:....:.:|......::|||:||:|||||    |.|:|:...:|.          :
Frog   781 KLCQAFENGKDLVELSDLYAHDISNVLKLYLRQLPEPLILFRLYTELIGLAKESQRASEELGVNS 845

  Fly   289 SHPKVTTQQA---------ELQQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLS 344
            |.|.:....:         :::.||:|||..|...|.:::.|...|.:....||::|.:|.::..
Frog   846 SSPTLKRLPSGVELNRVILKIRDLLKQLPTPNYNTLQYLIGHLHRVTEDVEENKMSASNLGIIFG 910

  Fly   345 PTL------------------QMSHRLMVALLCHCNNLFADVQLIKYVPPLTSTSPKLPDTPEDI 391
            |||                  ....|::..|:.:.:.:| ||.. |.:.|..|....:..|.|..
Frog   911 PTLIRPRQTDATISLSSLVDYPYQARIVELLITYYDRIF-DVSR-KMLNPEESQPESVSSTEERE 973

  Fly   392 QTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRK-LRTFEKKQE-KTAEEVDNSS 454
            ..::||..||  .:..|   .|:..:|...|.|     ..|:.| :...|:||. ...||::|:
Frog   974 PQQIRKSQSL--PVGKE---DFLLSRRASSLDE-----NSLQFKGVEERERKQSMDVLEEIENN- 1027

  Fly   455 SAPPAVASEDTTDSKPAGTPAVSTNNSISQEEP--KTDTLT 493
                ...::...||........||.|..:.:||  ..||::
Frog  1028 ----CCPNDFNMDSSSEVVSPGSTLNDCALDEPDCSMDTIS 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	52/222 (23%)
arhgap29	NP_001123763.2	BAR	228..462	CDD:386243
		C1	675..721	CDD:197519	8/45 (18%)
		RhoGAP	733..944	CDD:383032	51/214 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910