DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and arhgap17b

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_009297597.1	Gene:	arhgap17b / 100141341	ZFINID:	ZDB-GENE-080220-26	Length:	790	Species:	Danio rerio

Alignment Length:	567	Identity:	116/567 - (20%)
Similarity:	210/567 - (37%)	Gaps:	132/567 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LYASEAADAKSRKSK------------------EESDFSEDHDHSKKDLLIGRRKDKKEKGKDRG 60
            |..:...||:.|..|                  |||             |||:..|.....:::
Zfish    55 LQGNVGTDAEKRHKKLPLMILSQSMVEGVAQLGEES-------------LIGKMMDICGDAENK- 105

  Fly    61 YAALEGESSPEE---------------ELDTKSPSKSKKSKTFKFTSSKSKEKREKSRDKSEKDS 110
               |..|.|..|               |:|..:..|.::..........|.:.|.....||...:
Zfish   106 ---LAFEQSQHEVLLEKDILDPLNQLAEVDIPNIQKQRRHLAKLVLDYDSAKGRYHQATKSFPSA 167

  Fly   111 KHAEEEPSVSHKVKEKERDKEKDRDEPKKKDKEEKRKEKDKKADKKDKKDKKSKQLSQQQDD--- 172
            .:|:...:....:|| |.|:.::|.|   ..|::...:....|.|:.:..:....|.:.|.:
Zfish   168 TNAQAMAAKVDMLKE-EMDEAQNRME---ICKDQVAADMYSFASKEGEYARYYVLLLEAQAEYHR 228

  Fly   173 --VSAAEEVLA---------LGYPVFGVSVSLATERSRCHDGVDIPLVVRDCI-DFLQDHLKCEQ 225
              :::.|.||.         :..|.||.::....:|:    |.::.|.:..|: ..|:..::.|.
Zfish   229 RALASIESVLPNIQSQQDKWMEKPAFGTALEEHLKRT----GREVALPIEACVMMLLETGMQEEG 289

  Fly   226 IYKIEPIKTRLMHFKRLYNNREHDSAVDEL----NLPTA-CSLLKLFLRELPEPLLTTDLVARFE 285
            :::|....::|...|...     |.:..:|    :.|.| ...||.:||||||||::..|   :|
Zfish   290 LFRIAAGASKLKKLKAAL-----DCSTSQLEEFYSDPHAVAGALKSYLRELPEPLMSYQL---YE 346

  Fly   286 EVASHPKVTTQQAELQQL---LEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTL 347
            |......::.....||.|   .:.|||.|:|...:::.....:..:...||:.|.::|::|.|.|
Zfish   347 EWIQASNISDPDKRLQALWVVCDMLPKANKTNFRYLVKFLAKLALESDVNKMTASNIAIVLGPNL 411

  Fly   348 ----------QMSHRLMV-------ALLCHCNNLF-ADVQL-IKYVPPLTSTSPKLPDTPE-DIQ 392
                      :|:....|       .::.|....| .||.. :..|    ...|..|.||: :..
Zfish   412 LWAKTEGSLAEMAATTSVHVVSIIELIINHAGWFFPGDVDFNVSGV----FAMPGCPGTPDVEYG 472

  Fly   393 TELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFEKKQEKTAEEVDNSSSAP 457
            |..|::......:.|:      |.:::....:....   ..|:..|..|||..|.   :.....|
Zfish   473 TIERRRPGSQGSLDSD------TARKDSPANKQPEF---APRRTGTITKKQHSTP---NFQPPLP 525

  Fly   458 PAVAS-----EDTTDSKPAGTPAVSTNNSISQEEPKTD--TLTPKDA 497
            |..|.     |.......||..|:.|..::.|:.|.:|  :|:.:|:
Zfish   526 PIEAGGGSAFESCPQLPAAGLEALQTQQTLVQQSPASDNSSLSSRDS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	47/207 (23%)
arhgap17b	XP_009297597.1	BAR_Rich1	14..261	CDD:153302	41/226 (18%)
arhgap17b	XP_009297597.1	RhoGAP_nadrin	250..450	CDD:239851	48/211 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910