DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp5 and Akp3

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_073171.2	Gene:	Akp3 / 64621	RGDID:	621650	Length:	558	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	203/487 - (41%)
Similarity:	277/487 - (56%)	Gaps:	41/487 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EDTNAYWRQQGVQFVQQKLASEPNKRQAKNVILFLGDGMGVTTTSAARNLLG------GEEKSLS 115
            |:..|:|.|:....:......:|.:..|||:|:||||||||.|.:|.|.|.|      |.|..|:
  Rat    25 EENPAFWNQKAADALNVAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGNLGPETPLA 89

  Fly   116 FENFPFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIA 180
            .::||:..||||||||:.|||||.||||||||||....||||:.......|....  ...|.|:.
  Rat    90 MDHFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTF--GNEVLSVM 152

  Fly   181 KWAMEAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCGAGSGINDIAYQLARGEVGS 245
            ..|.:|||..|:||||||.||||:|.|.|...|:|..||::... ....|..|||.||..   ..
  Rat   153 YRAKKAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPAS-ALQEGCKDIATQLVS---NM 213

  Fly   246 KLKVIMGGGRKHF---------VDSSLESWGKRTDGLNLIDEFKSASENNVYVTTAAEL--AAVD 299
            .:.||:|||||:.         ..:.:...|.|.||.||:.|:.|..:.:.||....||  .::|
  Rat   214 DINVILGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEWLSKHQGSQYVWNRQELIQKSLD 278

  Fly   300 VTKTDRLLGLFNDDHLQYLMETTTESSQ-----PTLEQMTRKAIEYMSQNEQGYFLFIEGGRIDQ 359
            .:.| .|:|||..      ::|..|..:     |:|:.||..|:..:|:|.:|::||:||||||:
  Rat   279 PSVT-YLMGLFEP------VDTKFEIQRDPLMDPSLKDMTEAALHVLSRNPKGFYLFVEGGRIDR 336

  Fly   360 AHHINQARMALNETIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSYRGSDVFGKTPVNG 424
            .||:..|.:||.|.:.|..||..|.:||||.|||.:|||||||||::.||:.||:.:||..|:|.
  Rat   337 GHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLNA 401

  Fly   425 HDGKPYMVLSYANGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGVPIDMDSHGGDDVPVYALG 489
            .|||||..:.|.|||.|     ..|.||.:.|.....|...:..:.||:..::|||:||.::|.|
  Rat   402 LDGKPYTSILYGNGPGY-----VGTGERPNVTDAESHDPSYQQQAAVPVKSETHGGEDVAIFARG 461

  Fly   490 PWAHLFTGVYEQSTIPHMMAYASCLGDGHTMC 521
            |.|||..||.||:.|.|:||:|.|| :.:|.|
  Rat   462 PQAHLLHGVQEQNYIAHVMAFAGCL-EPYTDC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	194/451 (43%)
Akp3	NP_073171.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351424
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134333
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1947
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910