DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp5 and Alp9

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	287/517 - (55%)
Similarity:	375/517 - (72%)	Gaps:	16/517 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIAIVLVAHPAWSAPECGRTPEECREHRMHPDMPEPERHGKAFRVVDGEDTNAYWRQQGVQFVQQ 73
            |:.:|      |.|...||.|.:  |.||||.:|...|    .|.:.||:|..:|.....:.:::
  Fly    12 LLTVV------WGAAVPGRAPVD--EERMHPHLPTSPR----LRTISGEETQEFWHSASKKLIRE 64

  Fly    74 KLASEPNKRQAKNVILFLGDGMGVTTTSAARNLLGGEEKSLSFENFPFTGLSKTYSVDKIVPDSA 138
            ||....|.::|||:|||||||||:.|.:|||:.:||||..||||.||||||||||||||||||||
  Fly    65 KLEFVRNTKKAKNIILFLGDGMGLATLAAARSYIGGEELKLSFEEFPFTGLSKTYSVDKIVPDSA 129

  Fly   139 CTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIAKWAMEAGKWAGLVTTTRVTHASP 203
            ||:|:||||||...||||||..|.|.||..|.:|:.||.|:.||||:|||.||||||||||||||
  Fly   130 CTSTSYLCGVKANYGTIGVNAHVKRGDCAAMANETNHVFSLGKWAMDAGKAAGLVTTTRVTHASP 194

  Fly   204 SGVYAHIAERDWENDAEVATDCG-AGSGINDIAYQLARGEVGSKLKVIMGGGRKHFVDSSLESWG 267
            ||||||:|:|:|||:|.:...|| ...|:.|||.||..|||||||||::|||::.|........|
  Fly   195 SGVYAHVADREWENNAVLEEACGELSDGLQDIAVQLIHGEVGSKLKVMLGGGKRSFYSPEHYDKG 259

  Fly   268 KRTDGLNLIDEFKSASENNVYVTTAAELAAVDVTKTDRLLGLFNDDHLQYLME--TTTESSQPTL 330
            :||||.||::||::....|.:|.|..:|..|:.|:|.||||||:..|:.|.:|  ...::::|||
  Fly   260 RRTDGRNLVEEFEALDAGNTFVKTQKKLLNVNATETGRLLGLFSKSHMHYHLEQLADPDNNEPTL 324

  Fly   331 EQMTRKAIEYMSQNEQGYFLFIEGGRIDQAHHINQARMALNETIEFSKAIAAAQELTSEDDTLLV 395
            |:||:||||.:...|||||||:|||:||.:||...||:||:||.|.|||:..|:|:|:.::||:|
  Fly   325 EEMTQKAIEVLETEEQGYFLFVEGGKIDISHHETMARIALDETAELSKAVKKAREMTNPEETLIV 389

  Fly   396 VTADHSHVFTYAGYSYRGSDVFGKTPVNGHDGKPYMVLSYANGPSYENFYDAETMERKDPTTV-V 459
            ||:||||.|:.:||..||||:||....||.|||||:.||||||.|::::|:.||.||.|||:: .
  Fly   390 VTSDHSHTFSVSGYQPRGSDIFGAAKANGKDGKPYLALSYANGKSFQDYYNTETHERVDPTSLPT 454

  Fly   460 KGDHDDEFPSGVPIDMDSHGGDDVPVYALGPWAHLFTGVYEQSTIPHMMAYASCLGDGHTMC 521
            .||.|..||:.||::.::|||:||.|:|.|||||||||||||:|||||||:|:|:|||.|.|
  Fly   455 IGDFDQLFPAMVPLESETHGGEDVGVFASGPWAHLFTGVYEQNTIPHMMAFAACVGDGLTAC 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	259/433 (60%)
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	271/495 (55%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	259/432 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466619
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	1	1.000	-	-		H134333
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	12	11.800