DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp5 and Alp2

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_611654.1	Gene:	Alp2 / 37539	FlyBaseID:	FBgn0283480	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	209/475 - (44%)
Similarity:	288/475 - (60%)	Gaps:	23/475 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 YWRQQGVQFVQQKL-ASEPNKRQAKNVILFLGDGMGVTTTSAARNLLG------GEEKSLSFENF 119
            :|.:...:.:.::| ..:||..:|||||:||||||.::|.:|||.|.|      |||.|||||.|
  Fly    65 FWYKLADEEIAKRLQLPQPNSDRAKNVIMFLGDGMPISTVTAARILKGQRQGNTGEESSLSFEKF 129

  Fly   120 PFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIAKWAM 184
            |::|||:||..:..||||||||||||||||.....|||:..|...:|....|.:..:.|||:||.
  Fly   130 PYSGLSRTYCANAQVPDSACTATAYLCGVKTNIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQ 194

  Fly   185 EAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCGAGSGINDIAYQLARGEVGSKLKV 249
            .|||..|.||||.:|||||||.||..|.|.|::|.:|.:.....|...|:|.||.....|...:|
  Fly   195 NAGKSTGFVTTTTLTHASPSGAYAKTANRMWQSDTDVTSYGVDASTCVDMATQLVTQTPGKNFEV 259

  Fly   250 IMGGGRKHFVDSSLE----SWGKRTDGLNLIDEFKSASENNVYVTTAAELAAVDVTKTDRLLGLF 310
            :.|||...|:..:.:    .:|:|:||:||:..::...:..|.||...:|..:||:....::|.|
  Fly   260 MFGGGMGKFLPKTTKDSHGKYGERSDGVNLLSRWQGLHDKGVLVTNRKQLLNLDVSAASSIIGTF 324

  Fly   311 NDDHLQYLMETTTESSQPTLEQMTRKAIEYMSQNEQGYFLFIEGGRIDQAHHINQARMALNETIE 375
            ....:.:.|: ...:.||||.::|..||:.:|.||.|||:|||||.||..:|..||..||:|.:|
  Fly   325 QSGLMDFHMD-ADPTYQPTLSELTEVAIKKLSHNENGYFVFIEGGLIDYGNHYTQAGYALDEALE 388

  Fly   376 FSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSYRGSDVFGKTPVNGHD----GKPYMVLSYA 436
            |.|||..|:|:|:..|||:||||||.|..:.|||..||:.:.|   :|.||    |..|.||:||
  Fly   389 FEKAIQLAREMTNISDTLIVVTADHGHAVSIAGYPGRGTPILG---LNQHDTDINGVKYSVLNYA 450

  Fly   437 NGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGVPIDMDSHGGDDVPVYALGPWAHLFTGVYEQ 501
            .||   |.|..|..:| .|...:.|..|...||.:..::..|.|:||.::|.||.:||||||.:|
  Fly   451 AGP---NQYLDEHGQR-IPLDDILGPDDAISPSYIDKEIGVHSGEDVGIWASGPQSHLFTGVMQQ 511

  Fly   502 STIPHMMAYASCLGDGHTMC 521
            |||||:||||||:|.|..:|
  Fly   512 STIPHLMAYASCVGSGKQVC 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	201/443 (45%)
Alp2	NP_611654.1	ALP_like	89..525	CDD:304875	201/443 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466653
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900