DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp5 and Alpl

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_037191.2	Gene:	Alpl / 25586	RGDID:	2100	Length:	524	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	220/489 - (44%)
Similarity:	298/489 - (60%)	Gaps:	30/489 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VVDGEDTNAYWRQQGVQFVQQKLASEP-NKRQAKNVILFLGDGMGVTTTSAARNLLG------GE 110
            |.:.|...:|||||..:.::..|..:. |...|||:|:||||||||:|.:|||.|.|      ||
  Rat    19 VPEKEKDPSYWRQQAQETLKNALKLQKLNTNVAKNIIMFLGDGMGVSTVTAARILKGQLHHNTGE 83

  Fly   111 EKSLSFENFPFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTH 175
            |..|..:.|||..|||||:.:..|||||.||||||||||..|||:||:....||.|..  .:...
  Rat    84 ETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNT--TQGNE 146

  Fly   176 VDSIAKWAMEAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCGAGSGINDIAYQLAR 240
            |.||.:||.:|||..|:||||||.||:||..|||.|:|||.:|.|:..: ....|..||||||..
  Rat   147 VTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPE-ALSQGCKDIAYQLMH 210

  Fly   241 GEVGSKLKVIMGGGRKHF-------VDSSLE--SWGKRTDGLNLID---EFKSASENNVYVTTAA 293
            ..  ..:.||||||||:.       |:..|:  :.|.|.|||:||.   .||...:::.||....
  Rat   211 NI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRT 273

  Fly   294 ELAAVDVTKTDRLLGLFNDDHLQYLMETTTESSQPTLEQMTRKAIEYMSQNEQGYFLFIEGGRID 358
            ||.|:|.::.|.|||||....:||.: .....:.|:|.:|...|:..:::|.:|:||.:||||||
  Rat   274 ELLALDPSRVDYLLGLFEPGDMQYEL-NRNNLTDPSLSEMVEVALRILTKNPKGFFLLVEGGRID 337

  Fly   359 QAHHINQARMALNETIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSYRGSDVFGKTP-V 422
            ..||..:|:.||:|.:|..:||..|..:||:.|||.|||||||||||:.||:.||:.:||..| |
  Rat   338 HGHHEGKAKQALHEAVEMDEAIGKAGTMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMV 402

  Fly   423 NGHDGKPYMVLSYANGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGVPIDMDSHGGDDVPVYA 487
            :..|.||:..:.|.|||.|: ..|.   ||::.:.|....::.:..|.||:..::|||:||.|:|
  Rat   403 SDTDKKPFTAILYGNGPGYK-VVDG---ERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFA 463

  Fly   488 LGPWAHLFTGVYEQSTIPHMMAYASCLGDGHTMC 521
            .||.|||..||:||:.|||:||||||:|.....|
  Rat   464 KGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	208/448 (46%)
Alpl	NP_037191.2	Alk_phosphatase	51..490	CDD:395188	208/448 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351463
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1947
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810