DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp5 and Alppl2

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_031459.3	Gene:	Alppl2 / 11650	MGIID:	108009	Length:	529	Species:	Mus musculus

Alignment Length:	482	Identity:	183/482 - (37%)
Similarity:	268/482 - (55%)	Gaps:	30/482 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EDTNAYWRQQGVQFVQQKLASEPNKRQAKNVILFLGDGMGVTTTSAARNLLG------GEEKSLS 115
            |:..|:|.::..:.:......:|.:..|||:::.:||||||:|.:|.|.|.|      |.|..|:
Mouse    24 EENPAFWNRKAAEALDAAKKLKPIQTSAKNLVILMGDGMGVSTVTATRILKGQQQGHLGPETQLA 88

  Fly   116 FENFPFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIA 180
            .:.||...|||||:.||.:||||.|.||:|||||.....||::.......|....  ...|.|:.
Mouse    89 MDRFPHMALSKTYNTDKQIPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTW--GNEVVSVM 151

  Fly   181 KWAMEAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCGAGSGINDIAYQLARGEVGS 245
            ..|.:|||..|:||||.|.||||:|.|||...|.|.:||::... ....|..||:.||..   ..
Mouse   152 HRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRGWYSDAQMPAS-ALQDGCKDISTQLIS---NM 212

  Fly   246 KLKVIMGGGRKHF---------VDSSLESWGKRTDGLNLIDEFKSASENNVYVTTAAELAAVDVT 301
            .:.||:|||||..         ..:..:..|.|.||.||:.|:.:..:...||...:||....:.
Mouse   213 DIDVILGGGRKFMFPKGTPDQEYPTDTKQAGTRLDGRNLVQEWLAKHQGARYVWNRSELIQASLN 277

  Fly   302 KT-DRLLGLFNDDHLQYLMETTTESSQ-PTLEQMTRKAIEYMSQNEQGYFLFIEGGRIDQAHHIN 364
            :: ..|:|||..:.::|  |...:.:| |:|.:||..|:..:|:|.:|::||:||||||..||..
Mouse   278 RSVTHLMGLFEPNDMKY--EIHRDPAQDPSLAEMTEVAVRMLSRNPKGFYLFVEGGRIDHGHHET 340

  Fly   365 QARMALNETIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSYRGSDVFGKTPVNGHDGKP 429
            .|..||.|.:.|..|:..|.:||||.||:::|||||||||::.||:.||:.:||..|....|||.
Mouse   341 VAYRALTEAVMFDSAVDKADKLTSEQDTMILVTADHSHVFSFGGYTQRGASIFGLAPFKAEDGKS 405

  Fly   430 YMVLSYANGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGVPIDMDSHGGDDVPVYALGPWAHL 494
            :..:.|.|||.|:....|    |.|.|.....:...:..:.||:..::|.|:||.::|.||.|||
Mouse   406 FTSILYGNGPGYKLHNGA----RADVTEEESSNPTYQQQAAVPLSSETHSGEDVAIFARGPQAHL 466

  Fly   495 FTGVYEQSTIPHMMAYASCLGDGHTMC 521
            ..||.||:.|.|:||:|:|| :.:|.|
Mouse   467 VHGVQEQNYIAHVMAFAACL-EPYTDC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	175/446 (39%)
Alppl2	NP_031459.3	Alk_phosphatase	51..486	CDD:333956	175/446 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847860
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800