DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp5 and Akp3

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	488	Identity:	203/488 - (41%)
Similarity:	273/488 - (55%)	Gaps:	43/488 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EDTNAYWRQQGVQFVQQKLASEPNKRQAKNVILFLGDGMGVTTTSAARNLLG------GEEKSLS 115
            |:..|:|.::..:.:......:|.:..|||:|:||||||||.|.:|.|.|.|      |.|..|:
Mouse    25 EENPAFWNKKAAEALDAAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETPLA 89

  Fly   116 FENFPFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIA 180
            .:.||:..||||||||:.|||||.||||||||||....||||:.......|....  ...|.|:.
Mouse    90 MDRFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTF--GNEVFSVM 152

  Fly   181 KWAMEAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCGAGSGINDIAYQLARGEVGS 245
            ..|.:|||..|:||||||.||||||.|.|...|:|..||::... ....|..|||.||..   ..
Mouse   153 YRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNWYGDADMPAS-ALREGCKDIATQLIS---NM 213

  Fly   246 KLKVIMGGGRKHF---------VDSSLESWGKRTDGLNLIDEFKSASENNVYVTTAAEL--AAVD 299
            .:.||:|||||:.         ..:.....|.|.||.||:.|:.|..:.:.||....:|  .|.|
Mouse   214 DINVILGGGRKYMFPAGTPDPEYPNDANETGTRLDGRNLVQEWLSKHQGSQYVWNREQLIQKAQD 278

  Fly   300 VTKTDRLLGLFN------DDHLQYLMETTTESSQPTLEQMTRKAIEYMSQNEQGYFLFIEGGRID 358
            .:.| .|:|||.      |.....||:       |:|:.||..|::.:|:|.:|::||:||||||
Mouse   279 PSVT-YLMGLFEPVDTKFDIQRDPLMD-------PSLKDMTEAAVKVLSRNPKGFYLFVEGGRID 335

  Fly   359 QAHHINQARMALNETIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSYRGSDVFGKTPVN 423
            :.||:..|.:||.|.:.|..||..|.:||||.|||.:|||||||||::.||:.||:.:||..|:|
Mouse   336 RGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLN 400

  Fly   424 GHDGKPYMVLSYANGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGVPIDMDSHGGDDVPVYAL 488
            ..|||||..:.|.|||.|     ..|.||.:.|............:.||:..::|||:||.::|.
Mouse   401 ALDGKPYTSILYGNGPGY-----VGTGERPNVTAAESSGSSYRQQAAVPVKSETHGGEDVAIFAR 460

  Fly   489 GPWAHLFTGVYEQSTIPHMMAYASCLGDGHTMC 521
            ||.|||..||.||:.|.|:||:|.|| :.:|.|
Mouse   461 GPQAHLLHGVQEQNYIAHVMAFAGCL-EPYTDC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	195/452 (43%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	195/452 (43%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847873
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134333
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810