DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp5 and Alpl

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001274101.1	Gene:	Alpl / 11647	MGIID:	87983	Length:	524	Species:	Mus musculus

Alignment Length:	501	Identity:	223/501 - (44%)
Similarity:	300/501 - (59%)	Gaps:	42/501 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MPEPERHGKAFRVVDGEDTNAYWRQQGVQFVQQKLASEP-NKRQAKNVILFLGDGMGVTTTSAAR 104
            :||.||            ..:|||||..:.::..|..:. |...|||||:||||||||:|.:|||
Mouse    19 VPEKER------------DPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAAR 71

  Fly   105 NLLG------GEEKSLSFENFPFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPR 163
            .|.|      |||..|..:.|||..|||||:.:..|||||.||||||||||..|||:||:....|
Mouse    72 ILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATER 136

  Fly   164 TDCKVMLDESTHVDSIAKWAMEAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCGAG 228
            |.|..  .:...|.||.:||.:|||..|:||||||.||:||..|||.|:|||.:|.|:..: ...
Mouse   137 TRCNT--TQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPE-ALS 198

  Fly   229 SGINDIAYQLARGEVGSKLKVIMGGGRKHF-------VDSSLE--SWGKRTDGLNLID---EFKS 281
            .|..||||||....  ..:.||||||||:.       |:..|:  :.|.|.|||:||.   .||.
Mouse   199 QGCKDIAYQLMHNI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKP 261

  Fly   282 ASENNVYVTTAAELAAVDVTKTDRLLGLFNDDHLQYLMETTTESSQPTLEQMTRKAIEYMSQNEQ 346
            ..:::.||....||.|:|.::.|.|||||....:||.: .....:.|:|.:|...|:..:::|.:
Mouse   262 RHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYEL-NRNNLTDPSLSEMVEVALRILTKNLK 325

  Fly   347 GYFLFIEGGRIDQAHHINQARMALNETIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSY 411
            |:||.:||||||..||..:|:.||:|.:|..:||..|..:||:.|||.|||||||||||:.||:.
Mouse   326 GFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTP 390

  Fly   412 RGSDVFGKTP-VNGHDGKPYMVLSYANGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGVPIDM 475
            ||:.:||..| |:..|.||:..:.|.|||.|: ..|.   ||::.:.|....::.:..|.||:..
Mouse   391 RGNSIFGLAPMVSDTDKKPFTAILYGNGPGYK-VVDG---ERENVSMVDYAHNNYQAQSAVPLRH 451

  Fly   476 DSHGGDDVPVYALGPWAHLFTGVYEQSTIPHMMAYASCLGDGHTMC 521
            ::|||:||.|:|.||.|||..||:||:.|||:||||||:|.....|
Mouse   452 ETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	209/448 (47%)
Alpl	NP_001274101.1	Alk_phosphatase	51..490	CDD:333956	209/448 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847886
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	1	0.950	-	0	Normalized mean entropy	S3409
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R959
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.790