DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp5 and Alpp

DIOPT Version :9

Sequence 1:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	184/485 - (37%)
Similarity:	269/485 - (55%)	Gaps:	36/485 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EDTNAYWRQQGVQFVQQKLASEPNKRQAKNVILFLGDGMGVTTTSAARNLLG------GEEKSLS 115
            |:..|:|.::..:.::.....:|.:..|.|:|:.:||||||:|.:|.|.|.|      |.|..|:
  Rat    24 EENPAFWNRKAAEALEAAKKLQPIQTSANNLIILMGDGMGVSTVTATRILKGQQQGHLGPETPLA 88

  Fly   116 FENFPFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIA 180
            .:.||...|||||:.||.|||||.|.||:|||||.....||::.......|....  ...|.|:.
  Rat    89 MDRFPHMALSKTYNTDKQVPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTW--GNEVVSVM 151

  Fly   181 KWAMEAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCGAGSGINDIAYQLARGEVGS 245
            ..|.:|||..|:||||.|.||||:|.|||...|:|.:||.::| .....|..|||.||..   .:
  Rat   152 HRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRNWYSDAHMST-AALQEGCKDIAMQLIS---NT 212

  Fly   246 KLKVIMGGGRKHFVDSSL---------ESWGKRTDGLNLIDEFKSASENNVYVTTAAELAAVDVT 301
            .:.||:|||||.......         :..|.|.||.||:.|:.:..:...||....||....:.
  Rat   213 DIDVILGGGRKFMFPKGTPDQEYPTDPQQAGTRLDGRNLVQEWLAKHQGAQYVWNRTELIQASLN 277

  Fly   302 KT-DRLLGLFNDDHLQYLMETTTESSQPTLEQMTRKAIEYMSQNEQGYFLFIEGGRIDQAHHINQ 365
            :: ..|:|||..:.::|.:: ...:..|:|.:||..|:..:|:|.:|::||:||||||..||...
  Rat   278 RSVTHLMGLFEPNDMKYNID-RDPTQDPSLAEMTEVAVHMLSRNPKGFYLFVEGGRIDHGHHEAI 341

  Fly   366 ARMALNETIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSYRGSDVFGKTPVNGHDGKPY 430
            |..||.|.:.|..|:..|.:||||.||:::|||||||||::.||:.|.:.:||..|....|||.:
  Rat   342 AYRALTEAVMFDSAVDKADKLTSEKDTMIIVTADHSHVFSFGGYTQREASIFGLAPFKAGDGKSF 406

  Fly   431 MVLSYANGPSYE--NFYDAETMERK--DPTTVVKGDHDDEFPSGVPIDMDSHGGDDVPVYALGPW 491
            ..:.|.|||.|:  |...|:..|.:  :||.        :..:.||:..::|.|:||.::|.||.
  Rat   407 TSILYGNGPGYKLNNGIRADVTEEESSNPTY--------QQQAAVPLSSETHSGEDVAIFARGPQ 463

  Fly   492 AHLFTGVYEQSTIPHMMAYASCLGDGHTMC 521
            |||..||.||:.|.|:||:|.|| :.:|.|
  Rat   464 AHLVHGVQEQNYIAHVMAFAGCL-EPYTDC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	176/449 (39%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	176/449 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351437
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1947
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910