DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Calx and slc8a1b

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001034233.1	Gene:	slc8a1b / 797199	ZFINID:	ZDB-GENE-060110-3	Length:	944	Species:	Danio rerio

Alignment Length:	916	Identity:	442/916 - (48%)
Similarity:	594/916 - (64%)	Gaps:	83/916 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGP 164
            |:.|::||:|.|. |.|.||::.|..||||.|:|:|:|||||||||||:||.|||.|:.:.:|.|
Zfish    59 CAPGVILPVWEPP-NPSFGDKVARATVYFVALVYMFLGVSIIADRFMASIEVITSQEKEITIKKP 122

  Fly   165 NNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMII 229
            |.......||||||||:||||||||||||||||||||:...:||:|||||.|||||||:|:|:||
Zfish   123 NGETTTTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFVII 187

  Fly   230 AVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLW 294
            .:|:..:|.||.|:::|||||||||.:|:|||:|::|||:|.:||::.|||.::||.|||:.|::
Zfish   188 GICVYVVPDGEHRKVKHLRVFFVTAAWSIFAYLWMYLILAVLSPGIVQVWEGLLTLFFFPICVVF 252

  Fly   295 AYIAERRLLVYKYMDKNYRVNK-RGTVVAGEHDQ-------VEMDAEKGPKQPMVTS-------- 343
            |:||:||||.|||:.|.||..| ||.::..|.|:       :|||.:      |:.|
Zfish   253 AWIADRRLLFYKYVYKRYRAGKHRGMIIETEGDRPLPSKVDIEMDGK------MLNSHAVDFLDG 311

  Fly   344 -----ARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATR 403
                 ....|.:. ||||||...:|.||:||:||.::|||..:|..|||::..|||||||.||||
Zfish   312 TLALELEDKDLDE-DEARREMAKILKELKQKHPDKEVEQLIELANYQVLSQQQKSRAFYRCQATR 375

  Fly   404 KMVGSGNLMRK---IQERAHSDLTEVKAQLHAGDDEEADDPI-RMYFEPGHYTVMENCGEFEVRV 464
            .|.|:||:::|   .|.|....:.||::      |...:||| :::|:|..|..:||||...|.|
Zfish   376 LMTGAGNILKKHAADQARKAVSMHEVRS------DTGENDPISKIFFDPCSYQCLENCGTVAVNV 434

  Fly   465 VRR-GDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIR 528
            :|| ||::...|||:.|:||||:||:|:...:|.:.|.||..::..|:.:||||:|||||.|.|.
Zfish   435 IRRGGDLNQTVSVEFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLIH 499

  Fly   529 LFN---PSEG--------------VKLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELK 576
            |.|   ..||              ..|.:|..|||.|.||||||||.|.:.|..::||||..|:|
Zfish   500 LSNVRVVHEGDEPETTEANHVETIATLGLPSTATVTIFDDDHAGIFTFEEPVTHVSESVGVMEVK 564

  Fly   577 VMRYSGARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKV 640
            |:|.|||||.|.|||.|...||. ..:|:|.:.|.|.|:|:|..|.|.:.:|....|.|..||.:
Zfish   565 VLRTSGARGVVSVPYKTIEGTARGGGEDFEDSHGFLEFQNDEILKTITVRVLNREEYHKQCSFFI 629

  Fly   641 HIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKPRN 705
            .:..|           .:.|      .......||....:||.|:....:..|..||..:.||..
Zfish   630 ELQTP-----------LWRR------RGWTVYRDEEKEVVKEEEEPLTGEEEEERRIAEMGKPML 677

  Fly   706 GELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDE---E 767
            |:.....|.|.||.|||.|||||:.|.|::.::||:||::||.:|:||...:    |:|||   |
Zfish   678 GDHPRVEVIIEESYEFKNTVDKLIKKTNLALLVGTNSWRDQFIEAITVSAGE----DDDDEECGE 738

  Fly   768 EEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIK 832
            |::||||.||.||:.:|||||||||||||...|:..|||||.:|||:||.|||.||:|||.:.:|
Zfish   739 EKLPSCFDYVMHFLTVFWKVLFAFVPPTDYWNGWACFVVSIIMIGVLTAFIGDLASHFGCTIGLK 803

  Fly   833 DSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHG 897
            |||||::|||||||:||||||.:||..|:.||..|||||||||||||||||:||:|||:||:|.|
Zfish   804 DSVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHNSKG 868

  Fly   898 MTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVI 962
            ..|.||||.:.|:|.||...|.|.:.::|:|| ...||.|||||:.:|.::..:.|.||:.|::.
Zfish   869 NDFRVEPGNLAFSVTLFTIFAFICVAVLMYRR-RPDIGGELGGPRTAKALTTMLFVSLWLLYILF 932

  Fly   963 CILEAY 968
            ..||||
Zfish   933 SSLEAY 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	442/916 (48%)
		Na_Ca_ex	126..297	CDD:279963	108/170 (64%)
		Na_Ca_ex_C	300..414	CDD:293103	56/134 (42%)
		Calx_beta	441..529	CDD:197594	42/89 (47%)
		Calx_beta	554..643	CDD:197594	40/89 (45%)
		Na_Ca_ex	800..965	CDD:279963	95/164 (58%)
slc8a1b	NP_001034233.1	caca	36..944	CDD:273296	442/916 (48%)
		Na_Ca_ex	84..255	CDD:279963	108/170 (64%)
		Na_Ca_ex_C	258..389	CDD:293103	57/137 (42%)
		Calx-beta	411..501	CDD:281194	41/89 (46%)
		Calx_beta	542..632	CDD:197594	40/89 (45%)
		Na_Ca_ex	771..935	CDD:279963	95/164 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2153
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I460
OMA	1	1.010	-	-		QHG59599
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		otm24329
orthoMCL	1	0.900	-	-		OOG6_101777
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3356
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910