DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and slc8a2b

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_009290185.1	Gene:	slc8a2b / 567212	ZFINID:	ZDB-GENE-050419-209	Length:	967	Species:	Danio rerio

Alignment Length:	933	Identity:	444/933 - (47%)
Similarity:	598/933 - (64%)	Gaps:	98/933 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
            ||..|::||:|.|. |..:.:::||..:|||.|:|:|:|||||||||||:||.|||.|:.|.:..
Zfish    64 ECKPGILLPVWKPV-NPGLVEQIVRAIIYFVSLMYMFLGVSIIADRFMASIEVITSQEKEVTITM 127

  Fly   164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMI 228
            ||....|..||||||||:||||||||||||||||||||:....|:||:|||||||||||:|:|:|
Zfish   128 PNGETSVATVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHGFKSGELGPGTIVGSAAFNMFVI 192

  Fly   229 IAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVL 293
            |.:|:..||.||||:|:||||||:||.:|:|||:||:|||||.:||::.||||:|||.:||:.|:
Zfish   193 IGICVWVIPEGEVRKIKHLRVFFITAFWSIFAYIWLYLILSVISPGIVEVWEALVTLCYFPVCVI 257

  Fly   294 WAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPK--------------------- 337
            .|:||:||||.||||.|.||.:||..||      ||.:.|..||
Zfish   258 LAWIADRRLLFYKYMSKRYRADKRTGVV------VETEGEMTPKGMEMMMDGKFPLRAGDIGIGT 316

  Fly   338 ------------QPMVTSARGNDAEAF-------DEARREYITLLTELRQKYPDADLEQLEMMAQ 383
                        ..|.|....|....:       ||:|:|.|.:|.:|:|||||.:|:||..:|.
Zfish   317 QEHYQDGTGHTTGTMATLPNSNSTTVYMDGVKDLDESRKEVIRILKDLKQKYPDKELDQLVELAN 381

  Fly   384 EQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDD--EEADDPI--RM 444
            ...|....|||||||:||||.|:|:||:::|     |:.....:|.:..||:  ||.|..:  |:
Zfish   382 YYALLHQQKSRAFYRVQATRMMIGAGNVLKK-----HAADQSRRAVVVGGDEALEEEDLAVCSRI 441

  Fly   445 YFEPGHYTVMENCGEFEVRVVRRGDI--STYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQ 507
            .||..|...|||||...:.||.||.:  ||: .|:|.|:||||:||:|:...:|.|.|.||...:
Zfish   442 SFESPHSQCMENCGSIMIPVVCRGGLGESTF-YVDYCTEDGTANAGSDYEYCEGTLVFKPGETRK 505

  Fly   508 RFRIEVIDDDVFEEDECFYIRLFN----PSEGV------------KLAVPMIATVMILDDDHAGI 556
            ..::.:||||:|||||.|::||.|    .:||:            :|..|::|||.|||||||||
Zfish   506 DIKVGIIDDDIFEEDEHFFVRLLNLRIGDAEGMFESDDMDQGPKARLVEPLMATVTILDDDHAGI 570

  Fly   557 FAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEK 620
            |.|||.:..::|.||..|:.|:|.||||||||:||.||..||. ...|||...|||.|.|:::.:
Zfish   571 FTFTDRMMRVSECVGTMEVTVVRNSGARGTVIIPYHTEPGTAQGGGVDYEDTHGELEFTNDQTTQ 635

  Fly   621 FIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEK 685
            .:.:.|:::..|||..:|.:.:.|||          :..|.......:.|....:|:|:.:|..
Zfish   636 TLQVRIIDDEEYEKHENFFIVLEEPR----------WLKRGISALLLNQEDAEGQLSAEEEEAR- 689

  Fly   686 KPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDA 750
                      ||..:.||..||.:...|.|.||.|||:|||||:.|.|::.|:||.||:|||.:|
Zfish   690 ----------RIAEMGKPVLGEHSRLEVVIEESYEFKSTVDKLIKKTNLALVIGTHSWREQFVEA 744

  Fly   751 LTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVIT 815
            :||...|..|.|.:..||..|||..||.||:.:||||||||||||:...|:..|||||.|||::|
Zfish   745 VTVSAGDGDEDDEEGREEHPPSCSDYVMHFLTVFWKVLFAFVPPTEYWNGWACFVVSITVIGLLT 809

  Fly   816 AIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFL 880
            |:|||.||:|||.:.::|:|||::||||||||||||||.:|||.|:.||..||||||||||||||
Zfish   810 AVIGDLASHFGCTVGLRDTVTAVVFVALGTSIPDTFASKVAAKQDQYADASIGNVTGSNAVNVFL 874

  Fly   881 GIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSK 945
            |||:||::||||.:..|..|||:||::.|:|.||...|.|.:.:::||| ...||.|||||:||:
Zfish   875 GIGVAWSVAAVYWAVQGKRFNVDPGSLAFSVTLFTIFAFICMAVLLFRR-RPSIGGELGGPRVSR 938

  Fly   946 YISAAILVFLWVFYVVICILEAY 968
            .::..:.:.||..|::...||||
Zfish   939 LLTTLLFLGLWFLYILFSSLEAY 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	444/933 (48%)
		Na_Ca_ex	126..297	CDD:279963	113/170 (66%)
		Na_Ca_ex_C	300..414	CDD:293103	55/153 (36%)
		Calx_beta	441..529	CDD:197594	40/91 (44%)
		Calx_beta	554..643	CDD:197594	40/89 (45%)
		Na_Ca_ex	800..965	CDD:279963	93/164 (57%)
slc8a2b	XP_009290185.1	caca	47..967	CDD:273296	444/933 (48%)
		Na_Ca_ex	90..261	CDD:279963	113/170 (66%)
		Na_Ca_ex_C	264..415	CDD:293103	57/161 (35%)
		Calx-beta	439..527	CDD:281194	40/88 (45%)
		Calx_beta	568..658	CDD:197594	40/89 (45%)
		Na_Ca_ex	794..922	CDD:279963	78/127 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2153
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I460
OMA	1	1.010	-	-		QHG59599
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		otm24329
orthoMCL	1	0.900	-	-		OOG6_101777
Panther	1	1.100	-	-	O	PTHR11878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3356
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010