DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Calx and fras1

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_005165392.1	Gene:	fras1 / 563428	ZFINID:	ZDB-GENE-060526-68	Length:	4003	Species:	Danio rerio

Alignment Length:	643	Identity:	124/643 - (19%)
Similarity:	220/643 - (34%)	Gaps:	224/643 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 DQVEMDAEKGPKQPMVTSARGNDA---EAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQ-- 385
            |.::....:|.:..:|..:..|.|   |.::.:     ..:|:..|..|....::|....:|:
Zfish  2873 DDIQNPTIEGKESFIVFLSSANGAVLTEPYEAS-----VYITDTTQDIPSMQFDKLAYTVKEKDG 2932

  Fly   386 ----------VLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSD---LT------------- 424
                      .|:..|..|.|     ||.|  |..:|...:||.::|   :|
Zfish  2933 VLHIPIFRTGDLSYKSSVRCF-----TRTM--SAMVMDDFEERRNADDSRITFQKGEKVKNCTVL 2990

  Fly   425 ---------EVKAQLHAG-----------------------DDEEADDPIRMYFEPGHYTVMENC 457
                     |.:.|:|.|                       :||:|.   .:.||...|.|.|..
Zfish  2991 IQDDSVFEPEEEFQVHLGSPQGDHWIGAMIGVNDIVTVTITNDEDAP---TIEFEQATYQVREPP 3052

  Fly   458 GE-----FEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDD 517
            |.     ..::|:|:||:...:.:...|:||:|.:|.|:..:..:|.:.||||...|::|::.::
Zfish  3053 GPDGIEVLNIKVIRKGDLDRTSKIRCSTRDGSAQSGVDYNPKSRVLKYSPGVDHIMFKVEILSNE 3117

  Fly   518 VFEEDECFYIRLFNPSEGVK--LAVPMIATVMILDDDHAGIFAFT-----------DSVFEITES 569
            ..|..|.|.: :..|.:.|:  |...:||||.|||.:.||.....           |.|.|:|:.
Zfish  3118 DREWHESFSL-VLGPDDPVEAVLGEIIIATVTILDQEAAGSLILPAPPIVVSLSDYDYVQEVTKE 3181

  Fly   570 VGR------FELKVM--------RYS---------GARGTVIVPYWTENDTATESKDYEGARGEL 611
            ..:      :.|..:        :||         |...|.:...|   :.||.: |..|||..
Zfish  3182 GSKKSPSPGYPLVCVTPCDPHYPKYSVMKERCEEAGINQTSLHFSW---EVATPT-DTSGARSP- 3241

  Fly   612 VFE---NNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTH 673
             ||   :|.....|:..:|:...:.:    :.|:.....|.|             |..|.|.|..
Zfish  3242 -FETVTDNTPYTTINHMVLDSIYFSR----RFHVRCVAQARD-------------KAGHLGTPLR 3288

  Fly   674 DELAAKIKE--VEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAK----- 731
            ..:.....|  :...||                    ||...|..::|.|.||:..|..|
Zfish  3289 SNIVTIGTEGSICHTPV--------------------TTGTARGFQAQSFIATLKYLDVKHKEHP 3333

  Fly   732 ------------------------ANVSAVLGTSSWKEQF------------------------K 748
                                    .|:..:|..|.:::|.                        .
Zfish  3334 NRIHISVQIPHQDGMLPLVSTMPLHNLHFLLSESIYRQQHVCSNLVTLKDLQGISETGFLDDVSY 3398

  Fly   749 DALTVIPADES--EFDNDDEEEEVPSCFSYVSHFVCLF-WKVLFAFVPPTDICGGYVT 803
            |::::.|..:.  :|:.:..|......:.:::...|:: :...:......|:|||.||
Zfish  3399 DSISLGPGYDRPYQFNPNVREPRTIQLYKHLNLKSCIWTFDAYYDMTELIDVCGGSVT 3456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	124/643 (19%)
		Na_Ca_ex	126..297	CDD:279963
		Na_Ca_ex_C	300..414	CDD:293103	20/102 (20%)
		Calx_beta	441..529	CDD:197594	26/92 (28%)
		Calx_beta	554..643	CDD:197594	24/125 (19%)
		Na_Ca_ex	800..965	CDD:279963	3/4 (75%)
fras1	XP_005165392.1	VWC	26..85	CDD:278520
		VWC	93..150	CDD:278520
		VWC	157..214	CDD:278520
		VWC	219..276	CDD:278520
		VWC	283..340	CDD:278520
		VWC	364..414	CDD:302663
		FU	419..465	CDD:238021
		Furin-like_2	424..512	CDD:292535
		FU	461..503	CDD:214589
		FU	507..551	CDD:214589
		GF_recep_IV	512..669	CDD:291509
		FU	555..597	CDD:214589
		Furin-like	588..762	CDD:279142
		FU	602..645	CDD:214589
		FU	648..700	CDD:214589
		FU	704..748	CDD:214589
		Furin-like	737..911	CDD:279142
		FU	754..796	CDD:214589
		FU	855..897	CDD:214589
		Furin-like	888..1054	CDD:279142
		FU	950..994	CDD:214589
		FU	1044..1086	CDD:214589
		Cadherin_3	<1097..1196	CDD:292802
		Cadherin_3	1166..1306	CDD:292802
		Cadherin_3	1406..1538	CDD:292802
		Cadherin_3	1526..1689	CDD:292802
		Cadherin_3	1658..1811	CDD:292802
		Cadherin_3	1777..1934	CDD:292802
		Cadherin_3	1901..2056	CDD:292802
		Cadherin_3	2025..2175	CDD:292802
		Cadherin_3	2144..2290	CDD:292802
		Cadherin_3	2258..2403	CDD:292802
		Cadherin_3	2372..2534	CDD:292802
		Calx-beta	2550..2647	CDD:295344
		Calx-beta	2672..2771	CDD:295344
		Calx-beta	2795..2891	CDD:295344	3/17 (18%)
		Calx-beta	2917..3008	CDD:295344	18/97 (19%)
		Calx-beta	3036..3130	CDD:295344	27/97 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900