DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and slc8a1a

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001032179.1	Gene:	slc8a1a / 553489	ZFINID:	ZDB-GENE-050809-1	Length:	974	Species:	Danio rerio

Alignment Length:	931	Identity:	444/931 - (47%)
Similarity:	617/931 - (66%)	Gaps:	73/931 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
            ||.||::||:|.|. |.|.||:|.|..||||.|.|:|:|||||||||||:||.|||.|:.:.:|.
Zfish    58 ECKEGVILPIWTPV-NPSFGDKLARATVYFVGLFYMFLGVSIIADRFMASIEVITSQEKEITIKK 121

  Fly   164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMI 228
            ||.......||||||||:||||||||||||||||||:|:...:|::|:|||.|||||||:|:|:|
Zfish   122 PNGETTTTTVRIWNETVSNLTLMALGSSAPEILLSVVEVCGHNFDAGELGPNTIVGSAAFNMFVI 186

  Fly   229 IAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVL 293
            |.:|:..||.||.|:::|||||||||.:|:|||.||:|||:|.:||::.|||.::||.|||:.||
Zfish   187 IGLCVSVIPEGEHRKVKHLRVFFVTATWSIFAYTWLYLILAVISPGIVEVWEGLLTLFFFPICVL 251

  Fly   294 WAYIAERRLLVYKYMDKNYRV-NKRGTVVAGEHD-------QVEMDAE--KGPKQPMVTSARGN- 347
            :|::|:||||.|||:.|.||| .|||.::..|.:       .:|||..  ....:..:..|..|
Zfish   252 FAWVADRRLLFYKYVYKRYRVGKKRGIIIETEGEPELQSKADIEMDGGMLNSHAEEFLDGAVDNE 316

  Fly   348 --DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGN 410
              ||:. ||||||...:|.||:||:|:.::|||..:|...||::..|||||||.||||.|.|:||
Zfish   317 DKDADE-DEARREMAKILKELKQKHPEKEMEQLVELANYHVLSQQQKSRAFYRCQATRLMTGAGN 380

  Fly   411 LMRKIQERAH-SDLTEVKAQLHAGDDEEADDPI--RMYFEPGHYTVMENCGEFEVRVVRR-GDIS 471
            :::|     | :|.......:|....|.:|:.|  :::|:||.|..:||||...:.|||| ||::
Zfish   381 ILKK-----HAADQARKALGIHELRSEVSDNDISSKIFFDPGTYQCLENCGTVALNVVRRGGDLT 440

  Fly   472 TYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNP---S 533
            :..||||.|:||||:||:|:...:|::.|.||..|:..|:::||||:|||||.|.:.|.|.   |
Zfish   441 STVSVEYRTEDGTANAGSDYQFTEGVIIFKPGETEKEIRVDIIDDDIFEEDEHFLVHLSNVKVIS 505

  Fly   534 EGVK--------------LAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGAR 584
            ||..              |.:|..|||.|.||||||||.|.:.:..|:||:|..|:||:|.||||
Zfish   506 EGANNGNPGTNHVDALAGLGLPSTATVTIFDDDHAGIFLFEEPIVHISESIGMMEVKVVRTSGAR 570

  Fly   585 GTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLA 648
            |.|::||.|...||. ..:|:|...|.|.|:|:|..|.|.:.|:::..|||:.:|.:.||||:|.
Zfish   571 GVVVIPYKTIEGTAKGGGEDFEDTHGVLEFQNDEISKTIQINIIDDEEYEKNKNFFLEIGEPQLV 635

  Fly   649 PDD---------------TNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELD--- 695
            ...               |:|:.:....:.|.:...:|....:.:..::.|:   :.||:.:
Zfish   636 EMSERKAMLLHECGGFVKTDKQLYGRDVYRKVQGRDKPIPSTIISISEDGEE---ETLTKKEKDE 697

  Fly   696 -RILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADES 759
             ||..:.:|..||.....|.|.||.|||:|||||:.|.|::.::||:||::||.:|:||     :
Zfish   698 RRIAEMGRPTLGEHVKLEVIIEESYEFKSTVDKLIKKTNLALLVGTNSWRDQFVEAITV-----N 757

  Fly   760 EFDNDDEE---EEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDA 821
            ..|:||||   |::||||.||.||:.:|||||||||||||...|:..|:|||.:|||:||.|||.
Zfish   758 SGDDDDEECGQEKMPSCFDYVMHFLTVFWKVLFAFVPPTDYWNGWACFIVSIMMIGVLTAFIGDI 822

  Fly   822 ASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAW 886
            ||:|||.:.:||||||::|||||||:||||||.:||..|:.||..|||||||||||||||||:||
Zfish   823 ASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVTGSNAVNVFLGIGVAW 887

  Fly   887 TIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAI 951
            :|||::|.|.|..|.|:|||:.|:|.||...|.:.|.::|:|| ...||.|||||:..|.|:..:
Zfish   888 SIAAIFHQSQGRQFRVDPGTLAFSVTLFTIFAFVCIAVLMYRR-RPEIGGELGGPRHPKIITTTL 951

  Fly   952 LVFLWVFYVVICILEAYDVIR 972
            ...||:.|:::..:|||.:|:
Zfish   952 FFSLWLMYIILSSMEAYCIIK 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	444/931 (48%)
		Na_Ca_ex	126..297	CDD:279963	108/170 (64%)
		Na_Ca_ex_C	300..414	CDD:293103	55/126 (44%)
		Calx_beta	441..529	CDD:197594	43/90 (48%)
		Calx_beta	554..643	CDD:197594	38/89 (43%)
		Na_Ca_ex	800..965	CDD:279963	93/164 (57%)
slc8a1a	NP_001032179.1	caca	6..974	CDD:273296	444/931 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2153
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I460
OMA	1	1.010	-	-		QHG59599
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		otm24329
orthoMCL	1	0.900	-	-		OOG6_101777
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.840