DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and Frem3

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001161370.1	Gene:	Frem3 / 333315	MGIID:	2685641	Length:	2127	Species:	Mus musculus

Alignment Length:	919	Identity:	172/919 - (18%)
Similarity:	296/919 - (32%)	Gaps:	313/919 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 MDDELEQMT--------KVHGEA------------PDAEEL-----RECSEGLVLPLWMP----Q 112
            :|||:.|:|        ..|.|.            .|.:.|     .|..:||:..|..|    :
Mouse  1292 VDDEVPQLTINDGLEIETGHSEIITNHILKAIDLDSDNKSLSFVLHSEPQQGLLQRLRKPGGDAK 1356

  Fly   113 RNISVG-----DRLVRGFVYFV---------LLIYLFVGVSIIADRFM--------AAIEAITSI 155
            .|::||     |.:.||.::::         |...:..||:.:.||:.        :|:..|.|
Mouse  1357 HNLTVGMNFTQDEIDRGLIHYIHTGQGEAVDLKFDVTDGVNTLRDRYFYITIDNSNSAVPEIVS- 1420

  Fly   156 ERAVVVKGPNNT---------------------------------------------------KQ 169
            :|..:.:|...|                                                   .:
Mouse  1421 KRVTLTEGNRMTLTTELLNTSDIHSPGEQLLYSITRAPSTGHLESSDQPGEPMASFTQLQLARNK 1485

  Fly   170 VMHVRIWNETVA--NLTLMALGSSAPEILLSVIEIYAKDFESGDL---------GPGTIVGSAAY 223
            :.:|.|.|:.:.  :..|...|....|..:..|.:..:|.:...|         |...:|..:..
Mouse  1486 ISYVHISNDKIKLDHFELRVTGGHHSESRIFRIFVTEQDNKKPTLTIQALALQRGDNIVVTPSQL 1550

  Fly   224 NL--------FMIIAVCMIWIPAGEVRRIRHLRVFF-----VTALFSVFAYVWLWLILSVFTPGV 275
            .:        |::..:..|.|         |.|:.:     ||....           ...|..:
Mouse  1551 TVEDEDTPADFILFTITQIPI---------HGRILYNGSRPVTTFTK-----------KDLTKSL 1595

  Fly   276 IL----------------VWEAIVTLLF-FPLTVLWAYIAERRLLVYKYMD-------------- 309
            ||                |.:.|.|..: ||.|.|..::.:...:.....|
Mouse  1596 ILYCHDGSETSKDSFSFTVTDGIHTGFYVFPDTSLETHVPQTVWIQISPFDDRLPQMGINRGATA 1660

  Fly   310 -KNYRVNKRGTVVAGE----------HDQVEMDAEKGPKQPMVTSA-RGNDAEAFDEARREYITL 362
             |.......|.::..|          |..:.....:||:...:.:| .||
Mouse  1661 LKLLHTGHLGFLITNEYLQATHQGVPHRLLTYKVTRGPEHGYIVNAGLGN--------------- 1710

  Fly   363 LTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVK 427
              |....:..||::::               |.:|             ::.|.:.||..|.....
Mouse  1711 --ENTHMFTQADIDEM---------------RVYY-------------ILNKGRGRATRDTFYFS 1745

  Fly   428 AQLHAGDDEEADDPIRMYF-----EPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASA 487
            .:...| .:..:.|..:.:     |..:|.|.|:...|||.:.|||.:...:.|...|:..||..
Mouse  1746 VETRGG-KQLRNQPFHLNWAWISLEKEYYIVDEDSPFFEVTLTRRGYLGGTSVVSIGTKGDTAEE 1809

  Fly   488 GTDFVGRKGLL-SFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDD 551
            ..||.|:..:| .|.||.....:|:.:|.|..:|..|.|.|.|..|. ...|..|.:|||.|:|.
Mouse  1810 NKDFKGKAPMLVQFSPGQSTATWRVGLIPDTKYETSETFQIILSEPG-AAALEFPEMATVEIVDP 1873

  Fly   552 DHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATES--------KDY---- 604
            :........::.:::.|:||.|.:.|.|.......:.|...|...:||.:        .||
Mouse  1874 EDESTVYIPEAEYQLAEAVGEFLVPVRRSGDTSQELTVICSTRPGSATGTIPSVQLSLSDYVSRP 1938

  Fly   605 EGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPR---------------LAPDDTNK 654
            |.....|.||.:||||...:.|:.:|.||::.||.:.:..|.               ||  |...
Mouse  1939 EDNTSMLHFEKDESEKTCQVLIINDSLYEEEESFSIALSLPTGGQLGAKFPTARVTILA--DRED 2001

  Fly   655 ESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSK---PRNGELTTAYVRIR 716
            |...:  ||..|:..|    |.|..::....:....|::...:::.|:   .:..|..|.|:.:|
Mouse  2002 EPALH--FECSEYHAE----ESAGYVEVAVWRRGTGLSQASSVIVRSRGTEEQAAEAGTDYIGVR 2060

  Fly   717 ESQEFKATVD-----------------------KLVAKANVSAVLGTSSWKEQFKDALTVIPADE 758
            :...|...|.                       :|:.:....||:|     |..|..:|:    .
Mouse  2061 QHLHFSPGVSVQRLRVTILDDLPQPAFEGPEMFELLLQMPTGAVIG-----EPNKTTVTI----N 2116

  Fly   759 SEFDNDDEE 767
            ....|.:||
Mouse  2117 DSVTNCEEE 2125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	172/919 (19%)
		Na_Ca_ex	126..297	CDD:279963	39/279 (14%)
		Na_Ca_ex_C	300..414	CDD:293103	15/139 (11%)
		Calx_beta	441..529	CDD:197594	29/93 (31%)
		Calx_beta	554..643	CDD:197594	26/100 (26%)
		Na_Ca_ex	800..965	CDD:279963
Frem3	NP_001161370.1	CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	298..399
		Cadherin_3	<305..396	CDD:292802
		Cadherin_3	369..513	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	424..514
		Cadherin_3	485..>576	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	535..668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..601
		Cadherin_3	639..778	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	693..799
		Cadherin_3	766..913	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	820..911
		Cadherin_3	882..1030	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	939..1030
		Cadherin_3	998..1163	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1059..1161
		Cadherin_3	1129..1277	CDD:292802
		Cadherin_3	1245..1395	CDD:292802	21/102 (21%)
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1296..1395		18/98 (18%)
		Cadherin_3	1365..1508	CDD:292802	18/143 (13%)
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1414..1506		10/92 (11%)
		Cadherin_3	1476..1617	CDD:292802	22/160 (14%)
		Cadherin_3	1586..1746	CDD:292802	29/215 (13%)
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1649..1747		18/142 (13%)
		Calx-beta	1766..1853	CDD:295344	28/86 (33%)
		Calx-beta	1877..1977	CDD:295344	26/99 (26%)
		Calx-beta	2007..2097	CDD:295344	15/93 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900