DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and Frem3

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001178628.1	Gene:	Frem3 / 307767	RGDID:	1562701	Length:	2124	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	187/923 - (20%)
Similarity:	315/923 - (34%)	Gaps:	275/923 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ETEARQAYLNVTSSSSSNLSQDDGH--FLSRRLRQVSHGEEGDEGAPSQMDDELEQMTKVHGEAP 92
            :.||.|..:|      ..|..:.||  .::.|:.:.:..:..::.....:..||:|
  Rat  1289 DDEAPQLAIN------DGLEVETGHSEIITNRMLKATDPDSDNKSLSFVLHSELQQ--------- 1338

  Fly    93 DAEELRECSEGLVLPLWMP----QRNISVG-----DRLVRGFVYF----------VLLIYLFVGV 138
                      ||:..|..|    :.|::||     |.:.|..:.:          :|...:..||
  Rat  1339 ----------GLLQRLKKPGGDVRSNLTVGMNFTQDEIDRDLICYTHTGQGEAVDLLKFDVTDGV 1393

  Fly   139 SIIADR-FMAAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEI 202
            :.:.|. |...|....||...||.|         .|.:...:...||.....:||.......::.
  Rat  1394 NPLRDHYFYITISNSNSIIPEVVSK---------RVTLTEGSRVTLTTELFNTSAIHSPGEQLQY 1449

  Fly   203 YAK------DFESGDLGPGTIVGS-----AAYNLFMIIAVCMIWIPAGEVRRIRH--LRV----F 250
            ..|      ..||.| .||..:.|     .|.|  .|..||:    :.:.|::.|  |||    .
  Rat  1450 CIKRAPRTGHLESSD-QPGEPIASFTQLHLASN--KISYVCI----SKDERKMDHFELRVTGGHS 1507

  Fly   251 FVTALFSVF---------AYVWLWLILS-----VFTPGVILVWEAIVTLLFFPLTVLWAYIAERR 301
            .|:.:|.:|         ......|:|.     |.||..:.|.:......|...|:....|..|.
  Rat  1508 SVSRVFRLFVTDQDNKKPTLTIQTLVLQRGDSIVVTPSQLTVEDEDTPADFILFTITQVPIHGRI 1572

  Fly   302 LL-----VYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQPMVTSARGNDAEAF---DEARRE 358
            |.     |..:..|:...|    |:...||..|..               .|:.:|   |.....
  Rat  1573 LYNGSHPVTTFTKKDLTEN----VILYRHDGSETT---------------KDSFSFTVTDGIHAG 1618

  Fly   359 YITLLTELRQKYPDADLE-QLEMMAQEQV-----------LARSSKSRAFYRIQATRKMVGSGNL 411
            :..        :||..|| .:..|.|.|:           :.|.:::...........::.|..|
  Rat  1619 FYV--------FPDTALETHVPQMVQIQISPLIDRLPQITINRGARALTILHTGHVGFLITSKYL 1675

  Fly   412 MRKIQERAHSDLTE-----------VKAQLHAGDDE-----EAD-DPIRMYF------------- 446
            ....|:..|..||.           |.|.|  ||:.     :|| |.:::|:
  Rat  1676 QATHQDAPHRLLTYKVTSGPEHGYIVNAGL--GDESTHTFTQADIDEMQIYYILNKDHGSATRDT 1738

  Fly   447 ---------------EPGH------------YTVMENCGEFEVRVVRRGDISTYASVEYETQDGT 484
                           :|.|            |.|.|:...|||.:.|||.:...:.:...|:..|
  Rat  1739 FYFSVGTSGGSQLRNQPFHLKWAWISLEKEYYIVDEDSPFFEVTLTRRGYLGGTSVISIGTKGDT 1803

  Fly   485 ASAGTDFVGRKGL-LSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMI 548
            |....||.|:... :.|.||.....:.:.:|.|..:|..|.|.|.|..| :...|..|.:|||.|
  Rat  1804 AEENKDFKGKAPTRVQFNPGQSTATWNVGLIPDTKYETSETFQIVLSEP-DMAALEFPEMATVEI 1867

  Fly   549 LDDDHAGIFAFTDSVFEITESVGRF------------ELKVM---RYSGARGTVIVPYWTENDTA 598
            :|.:........::.:::.|:||.|            ||.|:   |...|.||:.....:.:|..
  Rat  1868 VDPEDESTVYIPEAEYKLAEAVGEFLVPVRRSGDISQELTVICSTRPGSAAGTIPSMELSLSDYI 1932

  Fly   599 TESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEP--------------RLAP 649
            :..:|   .|..|.||..|.||...:.|:.:|.||::.||.:.:..|              .:..
  Rat  1933 SRPED---NRSRLHFEKEEREKTCQVLIINDSLYEEEESFSIALSLPMGGRLGARFPTARVTILA 1994

  Fly   650 DDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSK---PRNGELTTA 711
            |..::.:....:.|.|.       :|.|..::....:...||:....::|.|:   .:..|..|.
  Rat  1995 DREDEPALHFEYSEYHV-------EESAGSVEVAIWRRGTDLSLASSVVLRSRRTEQQAAEAGTD 2052

  Fly   712 YVRIRESQEFKATVD-----------------------KLVAKANVSAVLGTSSWKEQFKDALTV 753
            |:.:.::..|:..|.                       :|:.:....||||     |..|..:|:
  Rat  2053 YIGVSQNLHFRPGVSVQRLRVTILDDLPQPAFEGPEMFELLLQMPTGAVLG-----EPNKTTVTI 2112

  Fly   754 IPADESEFDNDDE 766
               |:|..:.::|
  Rat  2113 ---DDSTTNCEEE 2122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	187/923 (20%)
		Na_Ca_ex	126..297	CDD:279963	44/212 (21%)
		Na_Ca_ex_C	300..414	CDD:293103	22/133 (17%)
		Calx_beta	441..529	CDD:197594	27/128 (21%)
		Calx_beta	554..643	CDD:197594	26/103 (25%)
		Na_Ca_ex	800..965	CDD:279963
Frem3	NP_001178628.1	Cadherin_3	370..515	CDD:292802
		Cadherin_3	484..668	CDD:292802
		Cadherin_3	765..912	CDD:292802
		Cadherin_3	881..1026	CDD:292802
		Cadherin_3	994..1159	CDD:292802
		Cadherin_3	1125..1273	CDD:292802
		Cadherin_3	1241..1392	CDD:292802	21/127 (17%)
		Cadherin_3	1361..1505	CDD:292802	35/159 (22%)
		Cadherin_3	1473..1614	CDD:292802	33/165 (20%)
		Cadherin_3	1583..1743	CDD:292802	32/188 (17%)
		Calx-beta	1763..1850	CDD:295344	24/86 (28%)
		Calx-beta	1874..1974	CDD:295344	26/102 (25%)
		Calx-beta	2004..2094	CDD:295344	14/96 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900