DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and Frem2

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_766450.2	Gene:	Frem2 / 242022	MGIID:	2444465	Length:	3160	Species:	Mus musculus

Alignment Length:	477	Identity:	99/477 - (20%)
Similarity:	182/477 - (38%)	Gaps:	110/477 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 FEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGR-KGLLSFPPGVDEQRF 509
            ||..:|.:.|:....::.:.|||.:...:.:...|:||||....||.|: :..:.|.||.....:
Mouse  1762 FEKEYYLINEDSKFLDIVLTRRGYLGETSFISIGTRDGTAEKDRDFKGKAQKQVQFNPGQTRASW 1826

  Fly   510 RIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILD-DDHAGIFAFTDSVFEITESVGRF 573
            |:.::.|...|..|.|.:.|..|...: |..|.:.||.|:| .|.:.:| ...|.:.:.|.||..
Mouse  1827 RVRILSDGEHEHSETFQVVLSEPVLAI-LEFPTVTTVEIIDPGDESTVF-IPQSEYSVEEDVGEL 1889

  Fly   574 ELKVMRYSGARGTVIVPYWTENDTATES--------KDY----EGARGELVFENNESEKFIDLFI 626
            .:.:.|.......::|..:|:..|||.:        .||    |.....:.|:.:|.||...:.:
Mouse  1890 FIPIRRSGDISRELMVICYTQQGTATSTVRTSVLSYSDYISRPEDHSSVIRFDKDEREKMCRILV 1954

  Fly   627 LEESSYEKDVSFKVHIGEP--------------RLAPDDTNKESFFNRFFEKHEHSGEPTHDELA 677
            :::|.||::.:|:|.:..|              .:..|..::.:|   :|...::|    .||.|
Mouse  1955 IDDSLYEEEETFQVLLSMPMGGRIGDKFPGANVTILTDRDDEPAF---YFGDTQYS----VDESA 2012

  Fly   678 AKIKEVEKKPVQDLTELDRILLLSKPR---NGELTTAYVRIRESQEFKATVD------------- 726
            ..::....:...||::...:.:.|:..   :.:..|.||.|..:.:|...|:
Mouse  2013 GYVELQVWRTGTDLSKPSSVTVRSRKTESLSADAGTDYVGISRNLDFAPGVNMQTVRVVILDDLG 2077

  Fly   727 ----------KLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFV 781
                      :||.:..::|.||..|      .|...|....|:......:|.|.:|.......|
Mouse  2078 RPILEGIEKFELVLRMPMNAALGEPS------KATVSINDSASDLPKMQFKERVYTCNENDGRVV 2136

  Fly   782 CLFWK--------------------VLFAFV--PPTDICGGYVTFVVSIFVIGVITAIIGDA--- 821
            .:.::                    |:..|.  |.||:  ..|||:........:..::.||
Mouse  2137 AMIYRSGDIQHRSSVRCYTRQGSAQVMMDFEERPNTDV--STVTFLPGEMEKPCVLELMDDAVYE 2199

  Fly   822 --------------ASYFGCAL 829
                          :|.||.|:
Mouse  2200 DVEELRLVLGTPQGSSAFGAAV 2221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	99/477 (21%)
		Na_Ca_ex	126..297	CDD:279963
		Na_Ca_ex_C	300..414	CDD:293103
		Calx_beta	441..529	CDD:197594	23/83 (28%)
		Calx_beta	554..643	CDD:197594	23/100 (23%)
		Na_Ca_ex	800..965	CDD:279963	9/47 (19%)
Frem2	NP_766450.2	CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	312..406
		Cadherin_3	376..532	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	431..530
		Cadherin_3	500..665	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	553..664
		Cadherin_3	634..797	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	689..796
		Cadherin_3	763..909	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	817..908
		Cadherin_3	879..1026	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	934..1026
		Cadherin_3	993..1159	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1055..1157
		Cadherin_3	1125..1273	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1178..1271
		Cadherin_3	1241..1390	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1292..1388
		Cadherin_3	1359..1503	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1409..1501
		Cadherin_3	1471..1612	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1521..1610
		Cadherin_3	1581..1742	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1644..1741
		Calx-beta	1760..1847	CDD:295344	23/84 (27%)
		Calx-beta	1871..1971	CDD:295344	23/100 (23%)
		Calx-beta	1999..2091	CDD:295344	16/98 (16%)
		Calx-beta	2117..2209	CDD:295344	14/93 (15%)
		Calx-beta	2239..2330	CDD:295344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3130..3160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900