DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and Fras1

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_780682.3	Gene:	Fras1 / 231470	MGIID:	2385368	Length:	4010	Species:	Mus musculus

Alignment Length:	538	Identity:	116/538 - (21%)
Similarity:	202/538 - (37%)	Gaps:	104/538 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 EAIVTLLFFPLTVLWAYIAERRLLV--------YKYMDKNYRVNK-RGTVVAGEHDQVEMDAEKG 335
            |:....|..|...|.....:.::::        .::..|.||||: .|.:.|....|.:..:...
Mouse  2641 ESFTVGLSMPAYALLGEFTQAKVVINDTEDEPTLEFDKKTYRVNESAGFLFAPIKRQGDSSSTVS 2705

  Fly   336 ------PKQPMVTS-----------ARGNDAEA---FDEARREYITLLTELRQKYPDADLEQLEM 380
                  ||..|.:|           :||..||:   |...    :|:.|.......|::.|:.|.
Mouse  2706 AVCYTVPKSAMGSSLYALESGSDFKSRGRSAESRVIFGPG----VTVSTCDVMVIDDSEYEEEEE 2766

  Fly   381 MAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEADDPIRMY 445
            .  |..||.:|.:....| ||..|::.||          .:|.:.|.....|
Mouse  2767 F--EIALADASNNARIGR-QAVAKVLISG----------PNDASTVSLGNTA------------- 2805

  Fly   446 FEPGHYTVMENCGEFEVRVVRRG-DISTYASVEYETQ---DGTASAGTDFVGRKGLLSFPPGVDE 506
                 :|:.|:.|..::.|:|.| |:||:.||...|:   ..:|:.|.|:|.....:.|.||:.|
Mouse  2806 -----FTISEDAGTVKIPVIRHGTDLSTFTSVWCATRPSDPASATPGVDYVPSSRKVEFGPGITE 2865

  Fly   507 QRFRIEVIDD---DVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDD-DHAGIFAFTDSVFEIT 567
            |...:.::||   .|.|..|.|.:.| :.::|.:|..|..|.:.|.|. .......|:..:..:.
Mouse  2866 QYCTLTILDDTQYPVIEGLETFVVFL-SSAQGAELTKPSQAVIAINDTFQDVPSMQFSKDLLLVK 2929

  Fly   568 ESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGAR----GELVFENNESEKFIDLFILE 628
            |..|...:.::|.........|..:|:..:|...:|:|..|    ..:.|...:..|...::|.:
Mouse  2930 EKEGVLHIPIIRSGDLSYESSVRCYTQGHSAQVMEDFEERRNADSSRITFLKGQKTKNCTVYIHD 2994

  Fly   629 ESSYEKDVSFKVHIGEP--------RLAPDDTNKESFFN-------RFFEKHEHSGEPTHDELAA 678
            :|.:|.:..|:|::|.|        |:..:.....:..|       .|.|......||...|..|
Mouse  2995 DSMFEPEEQFRVYLGHPLGNHWSGARIGKNSVATVTISNDEDAPTIEFEEAAYQVREPAGPEAIA 3059

  Fly   679 --KIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTS 741
              .||.:.:   .|.....:|...::..:.:....|.......:|...||.:..|..   :|...
Mouse  3060 VLSIKVIRR---GDQNRTSKIRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVE---ILSNE 3118

  Fly   742 --SWKEQFKDALTVIPAD 757
              .|.|.|  :|.:.|.|
Mouse  3119 DREWHESF--SLVLGPDD 3134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	116/538 (22%)
		Na_Ca_ex	126..297	CDD:279963	4/16 (25%)
		Na_Ca_ex_C	300..414	CDD:293103	32/142 (23%)
		Calx_beta	441..529	CDD:197594	27/94 (29%)
		Calx_beta	554..643	CDD:197594	17/92 (18%)
		Na_Ca_ex	800..965	CDD:279963
Fras1	NP_780682.3	VWC	27..86	CDD:214564
		VWC	94..151	CDD:278520
		VWC	158..215	CDD:278520
		VWC	220..277	CDD:278520
		VWC	284..341	CDD:302663
		VWC	368..415	CDD:302663
		FU 1	408..459
		GF_recep_IV	411..527	CDD:291509
		FU	420..>458	CDD:238021
		FU 2	461..504
		FU	461..503	CDD:214589
		FU 3	506..552
		FU	507..551	CDD:214589
		GF_recep_IV	511..623	CDD:291509
		FU 4	554..598
		FU	555..597	CDD:214589
		FU 5	601..646
		GF_recep_IV	606..728	CDD:291509
		FU	607..652	CDD:238021
		FU 6	648..704
		FU	649..703	CDD:214589
		FU 7	707..752
		FU	707..751	CDD:214589
		FU 8	754..799
		FU	754..798	CDD:214589
		Furin-like	759..912	CDD:279142
		FU 9	802..851
		FU	803..850	CDD:214589
		FU 10	853..899
		FU	853..898	CDD:214589
		FU 11	902..947
		Furin-like	905..1055	CDD:279142
		FU 12	951..996
		FU	951..995	CDD:214589
		FU 13	998..1041
		FU	1004..1048	CDD:238021
		Furin-like_2	1008..1098	CDD:292535
		FU 14	1045..1088
		FU	1045..1086	CDD:214589
		Cadherin_3	<1101..1197	CDD:292802
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1101..1196
		Cadherin_3	1167..1309	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1216..1307
		Cadherin_3	1278..1440	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1328..1440
		Cadherin_3	1411..1576	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1465..1561
		Cadherin_3	1531..1693	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1597..1691
		Cadherin_3	1662..1813	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1712..1812
		Cadherin_3	1780..1940	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1834..1938
		Cadherin_3	1906..2061	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1959..2059
		Cadherin_3	2030..2181	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2080..2179
		Cadherin_3	2149..2295	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2201..2293
		Cadherin_3	2263..2408	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2313..2406
		Cadherin_3	2377..2539	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2441..2538
		Calx-beta	2555..2648	CDD:295344	1/6 (17%)
Calx-beta	2673..2759	CDD:295344	19/89 (21%)
Calx-beta	2796..2892	CDD:295344	30/114 (26%)
Calx-beta	2918..3009	CDD:295344	17/90 (19%)
Calx-beta	3037..3131	CDD:295344	20/101 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810