DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and ncx-2

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_504414.4	Gene:	ncx-2 / 178918	WormBaseID:	WBGene00003567	Length:	975	Species:	Caenorhabditis elegans

Alignment Length:	960	Identity:	420/960 - (43%)
Similarity:	612/960 - (63%)	Gaps:	98/960 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 AEELRECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERA 158
            |:..|.|.:|||:|:|.|..:::.|||::||.:||.::.|:|:|:||:|||||::||.|||:||.
Worm    29 ADATRNCIDGLVIPIWRPFLDLTTGDRVLRGVLYFFVIAYMFLGISIVADRFMSSIEVITSMERT 93

  Fly   159 VVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAY 223
            :|||.|......:.|||||:||:|||||||||||||||||:||:.|:.||:|||||.|||||||:
Worm    94 IVVKRPGLDPMAVQVRIWNDTVSNLTLMALGSSAPEILLSIIEVIARGFEAGDLGPNTIVGSAAF 158

  Fly   224 NLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFF 288
            |||||||:|::.||.||:||.:||.||.|||.:||||||||:|||:.|:||.|.:||..:|.:||
Worm   159 NLFMIIAICVVVIPKGEIRRQKHLDVFCVTATWSVFAYVWLYLILAFFSPGEIEIWEGALTFIFF 223

  Fly   289 PLTVLWAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQPMVTSARGNDA-EAF 352
            ||||..||:|:.:|:..|::...||....|.::|.|.::::| .|.|        .:|:.| :||
Worm   224 PLTVFTAYMADIKLIQNKFLPHRYRRGSHGQMIATEAEEMKM-LENG--------TQGDPALKAF 279

  Fly   353 DEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQE 417
            :|.|:|:|.|:.|:|::.|.....:|:..|:.::::|..|||||||:||||:::|.|::::|..:
Worm   280 EEHRQEFIELMREIRKQNPHITPTELQKQAEYEMISRGPKSRAFYRVQATRRLIGGGDIVKKRID 344

  Fly   418 RAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG--DISTYASVEYET 480
            :.|:     ||...|.:.:..|:..:::.:|.||||:|:.|.|:|.|.|.|  |..| ..|:|.|
Worm   345 KEHN-----KALDAAQEKQSRDNTCKIFLDPAHYTVLESVGSFDVVVGRDGGPDGLT-VMVDYFT 403

  Fly   481 QDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFN----PSEGV----- 536
            :||:|:||:|::..||.|:|.|....|:..|||:|||||||||.||:||.|    ..:|:
Worm   404 EDGSANAGSDYIPVKGTLTFYPEDKHQKVTIEVVDDDVFEEDEHFYLRLCNLRVRTKDGIIIDPT 468

  Fly   537 --------KLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWT 593
                    :|.:|..||:|||||||||:|.|....|::.|:.|...|::.|:|||||.||:|:.|
Worm   469 RIGGLPVAQLEMPNTATIMILDDDHAGVFGFEHDHFQVVENCGHLSLQMKRHSGARGKVIIPFRT 533

  Fly   594 ENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAP--DDTNK-- 654
            ...||:..|.:|...||:|||:|::|..:::.|::...||:...|.:.:..|..|.  :|.::
Worm   534 VEGTASADKHFEMKEGEIVFEDNQTEALVEIGIVDTEQYERSDYFYIELSPPIWAKKMNDLSRIQ 598

  Fly   655 ESFFNRFFEKH------EHSGEPTHDELAAKIKEVEK------KPVQD-----------LTELDR 696
            |.|..|...|.      |.....|.:.||...|....      :|..|           ||...|
Worm   599 ERFQRRMERKRGSSVASESKDSNTENALAPAEKSTRAASVDLLQPSSDPRRSSQTNSPHLTSRFR 663

  Fly   697 -----------------------------ILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKA 732
                                         |..:.|||.||.|...:.||||:||:..||:::..|
Worm   664 NRLGSWIAGMKGGNGDDEVTTSLTPSQLEIAEMGKPRLGEFTKCQITIRESKEFQGIVDRMIKNA 728

  Fly   733 NVSAVLGTSSWKEQFKDALTVIPADESE------FDNDDEEEEVPSCFSYVSHFVCLFWKVLFAF 791
            |...:|||.||:|||.:||.|...|:.:      .|.:::|.|.|.|..||.|.:.:.||:.||.
Worm   729 NTRIMLGTHSWREQFMEALVVSAGDDDDDEGEDGEDGEEKEPEEPGCMDYVMHVLTVPWKLTFAT 793

  Fly   792 VPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIA 856
            :||||..||:.||||:||:|||:||::||.||.|||.:.:||:||||.|||||||:||||||.::
Worm   794 IPPTDYFGGWATFVVAIFMIGVLTAVVGDLASQFGCWVGLKDAVTAISFVALGTSVPDTFASKVS 858

  Fly   857 AKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIA 921
            |..|:.|||.:||||||||||||||||:||::||:||.:.|..|.|:||.:||:|.:||.||::.
Worm   859 AVQDKYADNAVGNVTGSNAVNVFLGIGIAWSMAAIYHWNQGTKFLVDPGNLGFSVLIFCTEAVLC 923

  Fly   922 IMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVI 971
            |::::.|| :|.:|.|||||...::::|.....||..|:::..||||.:|
Worm   924 IIVLVLRR-NKKVGGELGGPIALRWMTAMFFASLWFMYLLLSALEAYCII 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	420/960 (44%)
		Na_Ca_ex	126..297	CDD:279963	110/170 (65%)
		Na_Ca_ex_C	300..414	CDD:293103	38/114 (33%)
		Calx_beta	441..529	CDD:197594	43/89 (48%)
		Calx_beta	554..643	CDD:197594	33/88 (38%)
		Na_Ca_ex	800..965	CDD:279963	91/164 (55%)
ncx-2	NP_504414.4	caca	6..975	CDD:273296	420/960 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164735
Domainoid	1	1.000	234	1.000	Domainoid score	I1351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H62645
Inparanoid	1	1.050	770	1.000	Inparanoid score	I272
Isobase	1	0.950	-	0	Normalized mean entropy	S3307
OMA	1	1.010	-	-		QHG59599
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		oto18551
orthoMCL	1	0.900	-	-		OOG6_101777
Panther	1	1.100	-	-	LDO	PTHR11878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3356
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890