DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and ncx-3

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_501984.2	Gene:	ncx-3 / 177963	WormBaseID:	WBGene00003568	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	919	Identity:	308/919 - (33%)
Similarity:	459/919 - (49%)	Gaps:	152/919 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 CSEGLVLP-LWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAV---- 159
            |..|:::| |....||         ..:|...|.|.|:|::|.||.||.:||.|||..:.|
Worm     9 CKNGILIPALETTPRN---------AILYLAGLFYCFLGIAIAADIFMCSIEQITSATKKVKKQK 64

  Fly   160 -----VVKGPNN--TKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTI 217
                 |.|..:.  .:|..:|||||.||||||||||||||||||||:|||....|::||||||||
Worm    65 KAGQLVAKEEDEEIDEQYDYVRIWNPTVANLTLMALGSSAPEILLSIIEIVGNGFKAGDLGPGTI 129

  Fly   218 VGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAI 282
            |||||:|||.|.|:| ::....:.:||...|||.|||.|..|||:|::|:|.|.||.|:.|||||
Worm   130 VGSAAFNLFCISAIC-VFAVGTQTKRIELYRVFVVTAFFGTFAYIWVFLVLIVITPNVVDVWEAI 193

  Fly   283 VTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQP-------- 339
            :|||||.:.|:.:|..:.:  ::|        .|:.:.:..|.:..:.|. |...||
Worm   194 LTLLFFIILVVVSYAVDAQ--IWK--------KKKSSDLQEELEMAQHDG-KVDDQPEKLSDEIK 247

  Fly   340 -----MVTSARGND-----AEAFDEARREYITLLTELRQKYPD-ADLEQLEMMAQEQVLARSSKS 393
                 :..:...||     ..:.|..||    ....:...||. :|.:|.:::|. :|....|..
Worm   248 KWASNLSLNKEENDVIVDATPSVDTVRR----WTRSISHTYPSLSDEDQAKILAY-RVSRTMSHD 307

  Fly   394 RAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEADDPIR----MYFEPGHYTVM 454
            |.:|||:|.|::..|   .||.:|.      ||   |...:.|..|...|    :.|....|.|.
Worm   308 RLYYRIRAIRQLSSS---WRKSEEE------EV---LKMENQESTDSASRRKTFVEFSARVYRVD 360

  Fly   455 ENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVF 519
            .......:::.|:|::.:..:|.|.|.:|.|....:|:.:...|.|.||...:...|::|:...:
Worm   361 ATDETVSLKIERKGNMESKFTVSYATVNGLAKKDLNFLFKSETLQFNPGELHKTISIQLINAANW 425

  Fly   520 EEDECFYIRL----FNPSEGVKLAVPMIATVMILDDDH----AGIFAFTDSVFEITESVGRFELK 576
            ..::.||:.|    .:....:.|....:|.|.:.|:..    ..:..|....:.:.|:.|.....
Worm   426 RPNDVFYVHLKIQDVDEDSKICLGACNVAHVKMPDESKMILGGPVVEFVKPNYVVKENAGFSRSF 490

  Fly   577 VMRYSG-ARGTVIVPYWTENDTATESKDYEGAR-GELVFENNESEKFIDLFILEESSYEKDVSFK 639
            |.|..| .:..:.|.|.||:.||.:..||...: |.|.||..|.||:||:.::::...|||.:|.
Worm   491 VTRRGGKLKKPLQVHYETEDVTAKQGDDYTAVKDGILGFEGQEYEKYIDIDVIDDKMDEKDEAFI 555

  Fly   640 VH---IGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLS 701
            :.   :.||.::.....|.:.           ...:.|.:...|..|.|
Worm   556 IELLKVDEPGVSIGTRRKATI-----------TIISDDNVLKNITNVRK---------------- 593

  Fly   702 KPRNGELTTAYVR-IRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDD 765
                  |...|:| :|.                     |.::||||..:|::|...|.:
Worm   594 ------LMGHYMRQLRP---------------------GKATWKEQILNAVSVNAGDLA------ 625

  Fly   766 EEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALN 830
             ...|..|   :.|.:...||..|||:||..|..||..|||::..||::||::||.||.|||.:.
Worm   626 -NATVSDC---ILHALAFPWKFAFAFLPPPTIFYGYPCFVVALIGIGLVTAVVGDVASIFGCMVG 686

  Fly   831 IKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSS 895
            :||:||||..||||||:||||||.|||:.|:.|||.:|||||||:||||||:||.|.||::|.:|
Worm   687 LKDAVTAITLVALGTSLPDTFASKIAAESDDTADNAVGNVTGSNSVNVFLGLGLPWVIASLYWAS 751

  Fly   896 HGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIG-AELGGPKVSKYISAAILVFLWVFY 959
            .|.:|.|:.|.:||:|.:|...:::.:::::.||..|..| .|||||..:|.:||...|.||:.|
Worm   752 KGESFRVDAGDLGFSVTVFMICSVLFLVVLVLRRKLKAFGQGELGGPFGTKTLSALFFVGLWIVY 816

  Fly   960 VVICILEAY 968
            |.:.|.:.|
Worm   817 VGLSIWKMY 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	308/919 (34%)
		Na_Ca_ex	126..297	CDD:279963	97/181 (54%)
		Na_Ca_ex_C	300..414	CDD:293103	26/132 (20%)
		Calx_beta	441..529	CDD:197594	20/91 (22%)
		Calx_beta	554..643	CDD:197594	27/93 (29%)
		Na_Ca_ex	800..965	CDD:279963	86/165 (52%)
ncx-3	NP_501984.2	caca	8..825	CDD:273296	307/917 (33%)
		Na_Ca_ex	27..207	CDD:279963	97/180 (54%)
		Gp-FAR-1	<216..297	CDD:283480	15/85 (18%)
		Calx-beta	348..435	CDD:295344	19/86 (22%)
		Calx_beta	470..559	CDD:197594	27/88 (31%)
		Na_Ca_ex	659..822	CDD:279963	84/162 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59599
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101777
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690