DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and FREM3

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001161707.1	Gene:	FREM3 / 166752	HGNCID:	25172	Length:	2139	Species:	Homo sapiens

Alignment Length:	790	Identity:	164/790 - (20%)
Similarity:	278/790 - (35%)	Gaps:	214/790 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NVTSSSSSNLSQDDGHFLSRRLRQVSHGEEGD-EGAP----SQMDDELEQMTKVHGEAPDAEELR 98
            |:.::|..| |.|:.||...|...:.|.|..| .|.|    :|:.....:::.||  ..:.|:..
Human  1447 NLLTNSDIN-SSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH--TSNDEKKM 1508

  Fly    99 ECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
            :..|..|:....|         :.|.|..|                       ||.::
Human  1509 DSFEFQVIGELYP---------VFRTFRIF-----------------------ITDVD------- 1534

  Fly   164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMI 228
              |.|.::       |:..|||....|.    |::::|:..:|.::    |..::      ||.|
Human  1535 --NKKPIL-------TIHRLTLQKEDSQ----LITLLELTVEDSDT----PDDLI------LFTI 1576

  Fly   229 IAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVL 293
            ..|.|            |.::.:..:.                                 |:|..
Human  1577 TQVPM------------HGKILYNGSR---------------------------------PVTTF 1596

  Fly   294 WAYIAERRLLVYKY-----MDKNYRVNKRGTVVAGEHDQ--VEMD---AEKGP------------ 336
            ......:.|:.||:     .:.::.:    ||..|.|..  |..|   |...|
Human  1597 TKQDLNKNLISYKHDGSETTEDSFSL----TVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDN 1657

  Fly   337 KQPMVTSARGNDAEAFDEARREYI-TLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQ 400
            :.|.:|:.||  |.|.......:: .|:|....|..|.|                 ......:.:
Human  1658 RLPQITTNRG--APALKRLHTGHMGFLITSKSLKAEDQD-----------------SPHRLLKYK 1703

  Fly   401 ATRK-------MVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEAD----------------DPI 442
            .||.       ..|.||...::..:|..|..::...|:.|.:...|                .|.
Human  1704 VTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPF 1768

  Fly   443 RMYF-----EPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKG-LLSFP 501
            .:.:     |..:|.|.|:....||.:.|||.:...:.:...|:|.||....||..:.. .:.|.
Human  1769 HLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833

  Fly   502 PGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEI 566
            ||.....:|:.:|.|:.:|..|.|.|.|..|...| |..|.:|||.|:|..........::.::|
Human  1834 PGQTTATWRVRIIPDNEYETSETFQIILSEPLMAV-LEFPEMATVEIVDPGDESTVYIPEAEYKI 1897

  Fly   567 TESVGRFELKVMRYSGARGTVIVPYWTENDTATES-------KDY----EGARGELVFENNESEK 620
            .|.:|...:.|.|...|...:||...|...:||.:       .||    |.....|.|:.||::|
Human  1898 EEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQK 1962

  Fly   621 FIDLFILEESSYEKDVSFKVH----IGEPRLAPDDTNKESFF-NRFFEKHEHSGEPTH--DELAA 678
            ...:.|:::|.||::.||.|.    :|....|...|.|.:.. :|:.|...|.|:..:  :|.|.
Human  1963 TCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESAR 2027

  Fly   679 KIKEVEKKPVQDLTELDRILLLSK---PRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLG- 739
            .::....:...||::...|.:.|:   ..:.|..|.||.|..:.:|...|.....:..:...||
Human  2028 YVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQ 2092

  Fly   740 -TSSWKEQFK 748
             |....|:|:
Human  2093 PTLEGPEKFE 2102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	164/790 (21%)
		Na_Ca_ex	126..297	CDD:279963	22/170 (13%)
		Na_Ca_ex_C	300..414	CDD:293103	27/143 (19%)
		Calx_beta	441..529	CDD:197594	26/93 (28%)
		Calx_beta	554..643	CDD:197594	26/103 (25%)
		Na_Ca_ex	800..965	CDD:279963
FREM3	NP_001161707.1	CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	306..409
		Cadherin_3	377..524	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	432..522
		Cadherin_3	493..664	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	543..677
		Cadherin_3	647..788	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	702..807
		Cadherin_3	775..922	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	828..920
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	948..1040
		Cadherin_3	1007..1173	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1069..1171
		Cadherin_3	1139..1287	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1192..1285
		Cadherin_3	1255..1406	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1306..1404
		Cadherin_3	1375..1515	CDD:292802	18/70 (26%)
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1425..1516		18/71 (25%)
		Cadherin_3	1486..1627	CDD:292802	36/253 (14%)
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1536..1625		22/158 (14%)
		Cadherin_3	1596..1757	CDD:292802	32/183 (17%)
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1659..1756		21/115 (18%)
		Calx-beta	1778..1862	CDD:295344	25/83 (30%)
		Calx-beta	1886..1984	CDD:295344	26/97 (27%)
		Calx-beta	2011..2105	CDD:295344	20/92 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900