DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Calx and Slc8a3

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_536688.2	Gene:	Slc8a3 / 110893	MGIID:	107976	Length:	928	Species:	Mus musculus

Alignment Length:	926	Identity:	442/926 - (47%)
Similarity:	603/926 - (65%)	Gaps:	77/926 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GEAPDAEELRE-------CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFM 146
            |:.|.|.:..|       |.||::||:|.|: |.|:||::.|..||||.|||:|:||||||||||
Mouse    36 GDVPSAGQNNESCSGSSDCKEGVILPIWYPE-NPSLGDKIARVIVYFVALIYMFLGVSIIADRFM 99

  Fly   147 AAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGD 211
            |:||.|||.||.|.:|.||.......:|:|||||:|||||||||||||||||:||:....|.:||
Mouse   100 ASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGD 164

  Fly   212 LGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVI 276
            |||.|||||||:|:|:||.:|:..||.||.|:|:|||||||||.:|:|||:||::||:||:|||:
Mouse   165 LGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVV 229

  Fly   277 LVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVAGEHDQ---VEMDAEKGPK 337
            .|||.::||.|||:.||.|::|::|||.||||.|.||.:| ||.::..|.|.   :|||.:
Mouse   230 QVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGK---- 290

  Fly   338 QPMVTS--ARGN----DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAF 396
              |:.|  ..||    :.:..||:|||.|.:|.:|:||:|:.||:||..||....|:...|||||
Mouse   291 --MMNSHFLDGNFTPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAF 353

  Fly   397 YRIQATRKMVGSGNLMRK---IQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCG 458
            |||||||.|.|:||:::|   .|.:..|.::||..      ||..|...:::|:|..|..:||||
Mouse   354 YRIQATRMMTGAGNILKKHAAEQAKKTSSMSEVHT------DEPEDFASKVFFDPCSYQCLENCG 412

  Fly   459 EFEVRVVRR-GDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEED 522
            ...:.|||: ||||....|:|:|:||:|:||.|:...:|.:...||..::.|.:.:||||:||||
Mouse   413 AVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEED 477

  Fly   523 ECFYIRLFN--------------------PSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEIT 567
            |.|::||.|                    |.....||.|.:|||.||||||||||.|......::
Mouse   478 EHFFVRLSNVRVEEEQLAEGMLPAILNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVS 542

  Fly   568 ESVGRFELKVMRYSGARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESS 631
            ||:|..|:||:|.||||||||||:.|...||. ..:|:|.|.|||.|:|:|:.|.|.:.::::.:
Mouse   543 ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDAYGELEFKNDETVKTIHIKVIDDKA 607

  Fly   632 YEKDVSFKVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDR 696
            |||:.::.:.:..||:......|....         |.|.|..:|.  ::|.|.|         |
Mouse   608 YEKNKNYVIEMMGPRMVDMSVQKALLL---------SPEVTDRKLT--VEEEEAK---------R 652

  Fly   697 ILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEF 761
            |..:.||..||.....|.|.||.|||:|||||:.|.|::.|:||.||::||.:|:|| .|...|.
Mouse   653 IAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITV-SAGGDED 716

  Fly   762 DNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFG 826
            :::..||.:||||.||.||:.:|||||||.||||:.|.|:..|||||.:||::||||||.||:||
Mouse   717 EDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFG 781

  Fly   827 CALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAV 891
            |.:.:||||||::|||.|||:||||||..||..|..||..||||||||||||||||||||::||:
Mouse   782 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAI 846

  Fly   892 YHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLW 956
            |.:..|..|:|..||:.|:|.||...|.:.:.::::|| ...:|.|||||:..|..:..:.|.||
Mouse   847 YWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRR-RPHLGGELGGPRGCKLATTWLFVSLW 910

  Fly   957 VFYVVICILEAYDVIR 972
            :.|::...||||..|:
Mouse   911 LLYILFATLEAYCYIK 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	442/926 (48%)
		Na_Ca_ex	126..297	CDD:279963	112/170 (66%)
		Na_Ca_ex_C	300..414	CDD:293103	56/123 (46%)
		Calx_beta	441..529	CDD:197594	37/88 (42%)
		Calx_beta	554..643	CDD:197594	39/89 (44%)
		Na_Ca_ex	800..965	CDD:279963	88/164 (54%)
Slc8a3	NP_536688.2	caca	1..928	CDD:273296	442/926 (48%)
Slc8a3	NP_536688.2	Putative calmodulin-binding region. /evidence=ECO:0000250\|UniProtKB:P23685	253..272		11/18 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2309
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62645
Inparanoid	1	1.050	805	1.000	Inparanoid score	I492
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59599
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		otm43312
orthoMCL	1	0.900	-	-		OOG6_101777
Panther	1	1.100	-	-	LDO	PTHR11878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3356
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.870