DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Calx and Slc8a2

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_683748.1	Gene:	Slc8a2 / 110891	MGIID:	107996	Length:	921	Species:	Mus musculus

Alignment Length:	902	Identity:	431/902 - (47%)
Similarity:	594/902 - (65%)	Gaps:	60/902 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGP 164
            |..|::||:|.|: :.|:||::.|..||||.::|:|:|||||||||||:||.|||.|:.:.:...
Mouse    49 CQPGVLLPVWEPE-DPSLGDKVARAVVYFVAMVYMFLGVSIIADRFMASIEVITSKEKEITITKA 112

  Fly   165 NNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMII 229
            |....|..||||||||:||||||||||||||||:|||:...:|::|:|||||||||||:|:|::|
Mouse   113 NGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGELGPGTIVGSAAFNMFVVI 177

  Fly   230 AVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLW 294
            |||:..|||||.|:|:|||||||||.:|:||||||:|||:||:|||:.||||::||:|||:.|::
Mouse   178 AVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCVVF 242

  Fly   295 AYIAERRLLVYKYMDKNYRVNKR-GTVVAGEHD---QVEMDAE-KGPKQPMVTSARGN---DAEA 351
            |::|::|||.|||:.|.||.:.| |.::..|.|   .:|:|.. .|.:.|....|.|.   :|..
Mouse   243 AWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEARE 307

  Fly   352 FDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQ 416
            .|.:|||.|.:|.:|:||:||.|||||..:|:...|....||||||||||||.|.|:||::|
Mouse   308 LDASRREVIQILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLR--- 369

  Fly   417 ERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG--DISTYASVEYE 479
             |..:|............|:|.|...|::|||..|..:||||...:.|..:|  ..||: .|:|.
Mouse   370 -RHAADAARRPGATDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTF-YVDYR 432

  Fly   480 TQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFN----PSEGV---- 536
            |:||:|.||:|:...:|.|.|.||..::..||.:||||:|||||.|::||.|    .::|:
Mouse   433 TEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPD 497

  Fly   537 -------KLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTE 594
                   :|..|::|||.||||||||||:|.|.:..::|.:|..:::|:|.|||||||.:||.|.
Mouse   498 GGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTV 562

  Fly   595 NDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFF 658
            :.||. ....||.|.|||.|.::|:.|.:.:.|:::..|||..:|.:.:|:|:          :.
Mouse   563 DGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQ----------WL 617

  Fly   659 NRFFEK---HEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQE 720
            .|....   ::.:|              :||...:..|..||..:.||..||.....|.|.||.:
Mouse   618 KRGISALLLNQGNG--------------DKKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYD 668

  Fly   721 FKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFW 785
            ||.|||||:.|.|::.|:||.||:|||.:|:||...||.|.::...||.:||||.||.||:.:||
Mouse   669 FKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAGDEEEDEDGPREERLPSCFDYVMHFLTVFW 733

  Fly   786 KVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDT 850
            |||||.||||:.|.|:..|.|.|.||||:||:|||.||:|||.:.:||||.|::|||||||||||
Mouse   734 KVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDT 798

  Fly   851 FASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFC 915
            |||.:||..|:.||..|||||||||||||||:|:||::||||.:..|..|.|..||:.|:|.||.
Mouse   799 FASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFT 863

  Fly   916 GEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVIR 972
            ..|.:.|.::::|| ...||.|||||:..|..:.|:.:.||..|::...||||..||
Mouse   864 VFAFVCIAVLLYRR-RPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIR 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	431/902 (48%)
		Na_Ca_ex	126..297	CDD:279963	113/170 (66%)
		Na_Ca_ex_C	300..414	CDD:293103	54/121 (45%)
		Calx_beta	441..529	CDD:197594	39/89 (44%)
		Calx_beta	554..643	CDD:197594	36/89 (40%)
		Na_Ca_ex	800..965	CDD:279963	89/164 (54%)
Slc8a2	NP_683748.1	caca	1..921	CDD:273296	431/902 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..42
		Na_Ca_ex	74..245	CDD:279963	113/170 (66%)
		Na_Ca_ex_C	248..368	CDD:293103	54/119 (45%)
		Putative calmodulin-binding region. /evidence=ECO:0000250\|UniProtKB:P23685	248..267		10/18 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..391		3/19 (16%)
		Calx-beta	393..482	CDD:281194	39/89 (44%)
		Calx_beta	522..612	CDD:197594	36/89 (40%)
		Na_Ca_ex	748..912	CDD:279963	89/164 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2309
eggNOG	1	0.900	-	-		E1_KOG1306
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	805	1.000	Inparanoid score	I492
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		otm43312
orthoMCL	1	0.900	-	-		OOG6_101777
Panther	1	1.100	-	-	O	PTHR11878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3356
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860