DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and slc8a1

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_012819269.1	Gene:	slc8a1 / 100492166	XenbaseID:	XB-GENE-984129	Length:	978	Species:	Xenopus tropicalis

Alignment Length:	931	Identity:	438/931 - (47%)
Similarity:	611/931 - (65%)	Gaps:	72/931 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGP 164
            |.||::||:|.|| |.|.||::.|..||||.::|:|:||||||||||::||.|||.|:.:.:|.|
Frog    52 CKEGVILPIWEPQ-NPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKP 115

  Fly   165 NNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMII 229
            |.......||||||||:||||||||||||||||||||:...:|::|||||.|||||||:|:|:||
Frog   116 NGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGDLGPSTIVGSAAFNMFIII 180

  Fly   230 AVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLW 294
            |:|:..:|.||:|:|:|||||||||.:|:|||.||::|||||:|||:.|||.::|..|||:.|::
Frog   181 ALCVYVVPDGEIRKIKHLRVFFVTAAWSIFAYTWLYMILSVFSPGVVEVWEGLLTFFFFPICVVF 245

  Fly   295 AYIAERRLLVYKYMDKNYRVNK-RGTVVAGEHDQ------VEMD-------AEKGPKQPMVTSAR 345
            |::|:||||.|||:.|.||..| ||.::..|.|:      :|||       .|......:|....
Frog   246 AWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPSSKADIEMDGKVLNSHTETFLDGSLVLEVD 310

  Fly   346 GNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGN 410
            ..|.:. :||||:...:|.||:||:|:.::|||..:|..|||::..||||||||||||.|.|:||
Frog   311 EKDQDE-EEARRDMAKILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGN 374

  Fly   411 LMRKIQERAHSDLTEVKAQLH-AGDDEEADDPI-RMYFEPGHYTVMENCGEFEVRVVRR-GDIST 472
            :::    |..:|.......:| ...|...:||: ::|||...|..:||||...:.:||| ||::.
Frog   375 ILK----RHAADQARKAVSMHEVNTDVVENDPVSKIYFEQATYQCLENCGTVALTIVRRGGDLTN 435

  Fly   473 YASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVK 537
            ...|::.|:||:|:||:|:...:|.:.|.||..::..|:.:||||:|||||.|.:.|.|.....:
Frog   436 TVYVDFRTEDGSANAGSDYEFTEGTIIFKPGETQKELRVGIIDDDIFEEDENFLVHLSNVRVNAE 500

  Fly   538 ----------------LAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGT 586
                            |.....|||.|.||||||||.|.::|..::||||..|:||:|.||||||
Frog   501 NTEANLESNHVTPLACLGATCTATVTIFDDDHAGIFTFEETVTHVSESVGIMEVKVLRTSGARGT 565

  Fly   587 VIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPD 650
            |||||.|...||. ..:|:|...|:|.|:|:|..|.|.:.|:::..|||:.:|.:.:|||||...
Frog   566 VIVPYKTVEGTAKGGGEDFEDTCGQLEFQNDEIVKIISVKIIDDEEYEKNKTFFLEVGEPRLVEM 630

  Fly   651 DTNKESFFNRF------FEKHEHS-------GEPTHDELAAKIKEV------------EKKPVQD 690
            ...|....|..      .:|.:.:       |:|...::..:...:            ||:|:..
Frog   631 SEKKALLLNELDLKGAELQKRDFTITGKILYGKPVLRKVQVRDHPIPSTVIILTEENEEKQPLTS 695

  Fly   691 LTELD-RILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVI 754
            ..|.: ||..:.:|..||.|...:.|.||.|||:|||||:.|.|::.|:||:||:|||.:|:||
Frog   696 KEEEERRIAEMGRPVLGEHTRLEIIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITV- 759

  Fly   755 PADESEFDNDDE--EEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAI 817
              ...|.|:|||  ||::||||.||.||:.:||||||||||||:...|:..|:|||.:||::||.
Frog   760 --SAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSISMIGLLTAF 822

  Fly   818 IGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGI 882
            |||.||:|||.:.:||||||::|||||||:||||||.:||..|:.||..||||||||||||||||
Frog   823 IGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGI 887

  Fly   883 GLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYI 947
            |:||:|||:||:::|..|.|:|||:.|:|.||...|.|.:.::::|| ...||.|||||:.:|.:
Frog   888 GVAWSIAAIYHAANGDVFRVQPGTLAFSVTLFTIFAFINVGVLLYRR-RPEIGGELGGPRTAKLL 951

  Fly   948 SAAILVFLWVFYVVICILEAY 968
            :.|:...||:.|:....||||
Frog   952 TTALFTLLWLLYIFFSSLEAY 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	438/931 (47%)
		Na_Ca_ex	126..297	CDD:279963	109/170 (64%)
		Na_Ca_ex_C	300..414	CDD:293103	54/127 (43%)
		Calx_beta	441..529	CDD:197594	37/89 (42%)
		Calx_beta	554..643	CDD:197594	42/89 (47%)
		Na_Ca_ex	800..965	CDD:279963	91/164 (55%)
slc8a1	XP_012819269.1	caca	1..978	CDD:273296	438/931 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	813	1.000	Inparanoid score	I472
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		otm48461
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060