DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and slc8a3

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_004917314.1	Gene:	slc8a3 / 100487508	XenbaseID:	XB-GENE-954537	Length:	924	Species:	Xenopus tropicalis

Alignment Length:	898	Identity:	438/898 - (48%)
Similarity:	599/898 - (66%)	Gaps:	51/898 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
            ||.||::||:|.|: |.|:||::.|..||||.:||:|:|||||||||||:||.|||.||.:|:|.
Frog    52 ECKEGVILPIWYPE-NPSMGDKIARVIVYFVAMIYMFLGVSIIADRFMASIEVITSQEREIVIKK 115

  Fly   164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMI 228
            ||.......:|||||||:|||||||||||||||||:||:....|.:|||||.|||||||:|:|:|
Frog   116 PNGETSTTTIRIWNETVSNLTLMALGSSAPEILLSLIEVCGHGFLAGDLGPSTIVGSAAFNMFII 180

  Fly   229 IAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVL 293
            ||:|:..||.||||:::|||||||||.:|:|||:||::||:||:|||:.|||.::||.|||:.|:
Frog   181 IALCVYVIPDGEVRKVKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVV 245

  Fly   294 WAYIAERRLLVYKYMDKNYRVNK-RGTVVAGEHDQ---VEMDAEKGPKQPMVTSARGNDAEAFDE 354
            .|::|::|||.||||.|.||.:| |..::..|.|.   :|||.:......:..:....|.:..||
Frog   246 LAWVADKRLLFYKYMHKKYRTDKHRAIMIETEADHPKGIEMDGKVMNSHFLDGNLLNMDGKEVDE 310

  Fly   355 ARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRK---IQ 416
            :||:.|.:|.||:||:|:.||:||..||....|:...||||||||||||.|.|:||:::|   .|
Frog   311 SRRDMIRILKELKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQ 375

  Fly   417 ERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRR-GDISTYASVEYET 480
            .:..|.|.::..      ||..:...::||:|..|..:||||...:.|||: ||||....|:|:|
Frog   376 SKRSSSLQDICL------DESEEFVSKIYFDPCSYQCLENCGAVLLTVVRKGGDISKTVFVDYKT 434

  Fly   481 QDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFN--------PSE--- 534
            :||:|:||.|:...:|.|.|..|..::.|.:.:||||:|||||.|::||.|        |:|
Frog   435 EDGSANAGADYEFTEGTLVFKSGETQKEFSVGIIDDDIFEEDEHFFVRLSNIRITEAPEPAEPNS 499

  Fly   535 ----GVKLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTEN 595
                ...|..|.||::.||||||||||.|...:..::||:|..|:||:|.||||||||||:.|..
Frog   500 FSYPKAVLVSPYIASITILDDDHAGIFTFECDIIRVSESIGVMEVKVLRTSGARGTVIVPFRTIE 564

  Fly   596 DTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFN 659
            .||. ..:|||.:.|||.|:|:|:.|.|.:.|.::..|||:.:|.:.:.||.|......|....|
Frog   565 GTAKGGGEDYEDSYGELEFKNDETVKTIQIKIFDDEEYEKNKTFFIELREPHLVDLSVQKALLLN 629

  Fly   660 RFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKAT 724
            :                ||.:.| .|..|:: .|..||..:.||..||.....|.|.||.|||:|
Frog   630 Q----------------AADLTE-RKLSVEE-EEAKRIAEMGKPILGEHPKLEVVIEESYEFKST 676

  Fly   725 VDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLF 789
            ||||:.|.|::.|:||.||::||.:|:||..|.:.| :::..||.:||||.||.||:.:||||||
Frog   677 VDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEE-EDESGEERLPSCFDYVMHFLTVFWKVLF 740

  Fly   790 AFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASM 854
            |.||||:...|:..|||||.:||::||||||.||:|||.:.:||||||::|||.|||:||||||.
Frog   741 ACVPPTEYLNGWACFVVSIIIIGILTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASK 805

  Fly   855 IAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEAL 919
            :||..|..||..||||||||||||||||||||::||:|.:..|..|:|..||:.|:|.||...|.
Frog   806 VAATQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAYQGQEFHVSAGTLAFSVTLFTIFAF 870

  Fly   920 IAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVIR 972
            :.|.::::|| ...||.||||||..:..::.:.|.||:.|::...||||..|:
Frog   871 VCISVLLYRR-RPHIGGELGGPKGYRLATSLLFVSLWLLYILFATLEAYCYIK 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	438/898 (49%)
		Na_Ca_ex	126..297	CDD:279963	112/170 (66%)
		Na_Ca_ex_C	300..414	CDD:293103	52/117 (44%)
		Calx_beta	441..529	CDD:197594	39/88 (44%)
		Calx_beta	554..643	CDD:197594	41/89 (46%)
		Na_Ca_ex	800..965	CDD:279963	90/164 (55%)
slc8a3	XP_004917314.1	caca	1..924	CDD:273296	438/898 (49%)
		Na_Ca_ex	78..249	CDD:279963	112/170 (66%)
		Na_Ca_ex_C	252..373	CDD:293103	53/120 (44%)
		Calx-beta	394..484	CDD:281194	40/89 (45%)
		Calx_beta	523..612	CDD:197594	41/88 (47%)
		Na_Ca_ex	751..915	CDD:279963	90/164 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62645
Inparanoid	1	1.050	813	1.000	Inparanoid score	I472
OMA	1	1.010	-	-		QHG59599
OrthoDB	1	1.010	-	-		D109488at33208
OrthoFinder	1	1.000	-	-		FOG0000830
OrthoInspector	1	1.000	-	-		otm48461
Panther	1	1.100	-	-	LDO	PTHR11878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3356
SonicParanoid	1	1.000	-	-		X483
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110