DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Calx and Adgrv1

DIOPT Version :9

Sequence 1:	NP_001247215.1	Gene:	Calx / 42481	FlyBaseID:	FBgn0013995	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_038959317.1	Gene:	Adgrv1 / 100362255	RGDID:	1562101	Length:	6307	Species:	Rattus norvegicus

Alignment Length:	811	Identity:	167/811 - (20%)
Similarity:	266/811 - (32%)	Gaps:	264/811 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 VLWAYIAERRLLVYKYMDK----NYRVNKRGTVVAGEHDQVEMDAEKG----PKQPMVTSARGND 348
            ||.:....|.|::.:..|.    .:..:.||..|..|.|.||:...:.    .||.:.......|
  Rat   764 VLKSGYTSRDLIILENDDPGGIFEFSYDSRGPYVIKEGDAVELRIARSRGALVKQFLRFHVEPRD 828

  Fly   349 AE---------AFDEARRE-YITLLTELRQKYPDADLEQLEMMAQE------------------- 384
            :.         .|....|| .|||||.| ...|:.|.....:::..
  Rat   829 SNEFYGNTGVLEFSPGEREVVITLLTRL-DGMPELDEHYWVVLSSHGGRESKLGSATHVNITILE 892

  Fly   385 ---------------QVLARSSKS----RAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQL 430
                           .|..|.||.    .|.|.:..||...|:.|:...:...:..|:..|:..:
  Rat   893 NDDPHGIIEFASNGLTVSIRESKGEDVYHAVYGVVRTRGNFGAVNVSWMVSPNSTQDVFPVQGTV 957

  Fly   431 HAGDDE---------------------------------------------EADDPIRMYF-EPG 449
            ..||.|                                             ..||||  || ||.
  Rat   958 CFGDQENFKNITVYSFADEIPEEMEEFTIILLSATGGAQTGNQTTASLRILRNDDPI--YFAEPS 1020

  Fly   450 HYTVMENCGE-FEVRVVRRGDISTYASVEYETQDGTASAGT-DFVG-RKG-LLSFPPGVDEQRFR 510
            ...|.|  || ....|:|.|.:....:|:|.|.||.||.|. |||. .|| .|.|..|..||...
  Rat  1021 VVRVQE--GETANFTVLRNGSVDAACTVQYATVDGKASGGEGDFVPVEKGETLVFEVGSREQSVS 1083

  Fly   511 IEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMI-LDDDHAGIFAFTDSVFEITESVGRFE 574
            :.|.:|.|.|.||.|||.|||.:....:....:||::| .:||..|:|:. :.:.:..|......
  Rat  1084 VSVNEDGVPETDEPFYIILFNSTGDTVVYEYGVATIIIEANDDPNGVFSL-EPIDKAVEEGKTNA 1147

  Fly   575 LKVMRYSGARGTVIVPYWT-ENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSF 638
            ..::|:.|..|.|.|.:.. :|.:....:::....|.:.|.:.|..|.:.|
  Rat  1148 FWILRHRGHFGNVSVAWHLFQNASLQPGREFYETSGTVNFTDGEGTKPVIL-------------- 1198

  Fly   639 KVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKP 703
                   |..||...:   ||.|:              ..::..:.....| |.|.|..:.:..|
  Rat  1199 -------RAFPDRIPE---FNEFY--------------ILRLVNISGAGGQ-LAETDLQVTVMIP 1238

  Fly   704 RNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEE 768
            .|.:....::...|..|                       :|..:|.|:          .||
  Rat  1239 FNDDPFGVFILDPECLE-----------------------REVAEDVLS----------EDD--- 1267

  Fly   769 EVPSCFSYVSHFVCL-----------FWKVLF----AFVPPTDICGGYVTFVVSIFVIGVITAII 818
                 .||:::|..|           .|:||.    |.:||          :|...::||..:.:
  Rat  1268 -----MSYIANFTVLRQQGVFGDVRVGWEVLSRELPAGLPP----------MVDFLLVGVFPSTV 1317

  Fly   819 GDAASYFGCALNIKDSVTAILFV-----ALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNV 878
            .     ....:..:.|.|.:|:.     |.||..|         |:....:|.|.|.|.|
  Rat  1318 P-----LQPHMRHRHSGTDVLYFSGLEGAFGTVDP---------KYQPSRNNTIANFTFS----- 1363

  Fly   879 FLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAE---LGG 940
                  ||.:...|.:...:..:...|:|.:.|.:...|..:.:.|     .:|..|::   :..
  Rat  1364 ------AWVMPNAYTNGFLIAKDDSHGSIYYGVKIQTNETHVTLSL-----HYKTFGSDVTYIAK 1417

  Fly   941 PKVSKYISAAILVFLWVFYVVIC---ILEAY 968
            ....||:...:    |:..::|.   |:|.|
  Rat  1418 STAMKYLEDGV----WLHVLIILDDGIIEFY 1444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	167/811 (21%)
		Na_Ca_ex	126..297	CDD:279963	2/4 (50%)
		Na_Ca_ex_C	300..414	CDD:293103	34/169 (20%)
		Calx_beta	441..529	CDD:197594	40/92 (43%)
		Calx_beta	554..643	CDD:197594	14/89 (16%)
		Na_Ca_ex	800..965	CDD:279963	30/175 (17%)
Adgrv1	XP_038959317.1	caca	<53..>235	CDD:273296
		caca	<246..>486	CDD:273296
		caca	<678..>871	CDD:273296	26/107 (24%)
		caca	<869..>1102	CDD:273296	57/236 (24%)
		caca	<1010..>1213	CDD:273296	70/245 (29%)
		Laminin_G_3	1351..1500	CDD:404293	22/114 (19%)
		Calx-beta	1578..1670	CDD:413355
		caca	<1631..>1813	CDD:273296
		Calx-beta	1733..1813	CDD:413355
		caca	<1734..>1951	CDD:273296
		Calx-beta	1993..2083	CDD:413355
		caca	<2039..>2210	CDD:273296
		caca	<2145..>2328	CDD:273296
		caca	<2501..>2681	CDD:273296
		caca	<2611..>2795	CDD:273296
		Calx-beta	2849..2931	CDD:413355
		caca	<2880..>3056	CDD:273296
		caca	<3090..>3254	CDD:273296
		EPTP	3402..3434	CDD:397689
		caca	<3592..>3746	CDD:273296
		caca	<3893..>4129	CDD:273296
		caca	<4160..>4493	CDD:273296
		caca	<4883..>5134	CDD:273296
		Calx-beta	5007..5099	CDD:413355
		Calx-beta	5220..5335	CDD:413355
		caca	<5295..>5383	CDD:273296
		GPS	5854..5900	CDD:413374
		7tm_GPCRs	5921..6161	CDD:421689
		TM helix 2	5940..5962	CDD:410628
		TM helix 3	5973..5999	CDD:410628
		TM helix 4	6012..6032	CDD:410628
		TM helix 5	6059..6084	CDD:410628
		TM helix 6	6103..6129	CDD:410628
		TM helix 7	6133..6158	CDD:410628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000