DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and GLR3.4

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001030971.1	Gene:	GLR3.4 / 839268	AraportID:	AT1G05200	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	972	Identity:	214/972 - (22%)
Similarity:	370/972 - (38%)	Gaps:	191/972 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RGERTNVGLVYENTDPDLEKIFHLAISKANEE-NEDLQ-LHGVSVSI--EPGN--SFETSKKLCK 88
            |....|||.:: ..|..:.:....|:..|.:: |.|.. |.|:.::|  :..|  .|..:....:
plant    57 RPSSVNVGALF-TYDSFIGRAAKPAVKAAMDDVNADQSVLKGIKLNIIFQDSNCSGFIGTMGALQ 120

  Fly    89 MLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGV-------- 145
            ::...:||..||.|:..|.....:.:...:|.|    .|||..||::....|..|..
plant   121 LMENKVVAAIGPQSSGIAHMISYVANELHVPLL----SFGATDPTLSSLQFPYFLRTTQNDYFQM 181

  Fly   146 -ALRDMVVALGWESFTIIYES-----------GEYLPTVRELLQMYGTAGPTVTVRRYELDLNGN 198
             |:.|.:...||.....|:..           |:.|...|..:.......|...        :.:
plant   182 HAIADFLSYSGWRQVIAIFVDDECGRNGISVLGDVLAKKRSRISYKAAITPGAD--------SSS 238

  Fly   199 YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTN 263
            .|::|..:...:...|||..:..:....|..|:.:|::.|.|.:|.  .||....::..:|..::
plant   239 IRDLLVSVNLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIA--TDWLPTAMDSMEHVDSD 301

  Fly   264 -------ITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNSMAL-VYDGVQLLAETYKHVN 320
                   :...|..:.:| .|:....|.:::..|....     ||.|: .||.|.|:|... .|.
plant   302 TMDLLQGVVAFRHYTIES-SVKRQFMARWKNLRPNDGF-----NSYAMYAYDSVWLVARAL-DVF 359

  Fly   321 FRP---VALSCNDD---------------SAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDF 367
            ||.   :..| ||.               |.:::|...:..:..:...|:||||:||.:..|.:.
plant   360 FRENNNITFS-NDPNLHKTNGSTIQLSALSVFNEGEKFMKIILGMNHTGVTGPIQFDSDRNRVNP 423

  Fly   368 KLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVN---KSFVVITAISEP------ 423
            ..||:.|..:..:.:|.||...|.....|...:|..|: .|..|   |..:....:::|
plant   424 AYEVLNLEGTAPRTVGYWSNHSGLSVVHPETLYSRPPN-TSTANQRLKGIIYPGEVTKPPRGWVF 487

  Fly   424 --------YGMLKETS-----EKLEGNDQFEGFGIELIDELSKKLGFSY--TWRLQEDNKYGGID 473
                    .|:....|     .|.:......|:.|::.:...:.|.:..  |:.|..|.|
plant   488 PNNGKPLRIGVPNRVSYTDYVSKDKNPPGVRGYCIDVFEAAIELLPYPVPRTYILYGDGK----- 547

  Fly   474 PKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKL-FSFM 537
             :...::.::.|::....|:.:.|:|:.:.|...||||.||:..|:.::  .|:||.... :||:
plant   548 -RNPSYDNLVNEVVADNFDVAVGDITIVTNRTRYVDFTQPFIESGLVVV--APVKEAKSSPWSFL 609

  Fly   538 SPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQ 602
            .||:.|:|...|..::.|...:::|......|:..|      |..     ......|||...:..
plant   610 KPFTIEMWAVTGGFFLFVGAMVWILEHRFNQEFRGP------PRR-----QLITIFWFSFSTMFF 663

  Fly   603 QGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDL--SKNKGGVNYG 665
            ...|....:.. |.|...|.|..||:.|||||:|.:.||:..|.:.|...|.|  |....||..|
plant   664 SHRENTVSSLG-RFVLIIWLFVVLIINSSYTASLTSILTIRQLTSRIEGIDSLVTSNEPIGVQDG 727

  Fly   666 AKIGGATFNFFKESNYPTYQRMYEF------------MRDNPQYMT----NTNQEGVDRVENSNY 714
                             |:.|.|..            ::|..||::    ..|..||       .
plant   728 -----------------TFARNYLINELNILPSRIVPLKDEEQYLSALQRGPNAGGV-------A 768

  Fly   715 AFLMESTTIE-YITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTK 778
            |.:.|...|| .:|...|....||......|:|.|.:::.|....:|.|:|::.|:|.|.|:..|
plant   769 AIVDELPYIEVLLTNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTAILQLSEEGELEKIHRK 833

  Fly   779 WWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG----VKERSDEN 839
            |...|.   .||....:|....|.:.:..|:||:.|:..|..:.|....:...    :.|.:||.
plant   834 WLNYKH---ECSMQISNSEDSQLSLKSFWGLFLICGITCFMALTVFFWRVFWQYQRLLPESADEE 895

  Fly   840 QV----------------SFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMS 885
            :.                ||| ||   |:.:.:.....|.:...|:|.:..::..:.|:|.|
plant   896 RAGEVSEPSRSGRGSRAPSFK-EL---IKVVDKREAEIKEILKQKSSKKLKSTQSAAGTSQS 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	84/405 (21%)
		ANF_receptor	53..374	CDD:279440	78/372 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	96/413 (23%)
		Lig_chan	543..816	CDD:278489	73/291 (25%)
GLR3.4	NP_001030971.1	PBP1_GABAb_receptor_plant	62..450	CDD:380645	87/410 (21%)
		Periplasmic_Binding_Protein_Type_2	<518..591	CDD:389745	18/78 (23%)
		Lig_chan	615..869	CDD:365843	73/292 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920