Protein Alignment Grik and GLR2.5

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001332219.1
• Gene: GLR2.5 / 830991
• AraportID: AT5G11210
• Length: 918
• Species: Arabidopsis thaliana
• Alignment Length: 963
• Identity: 200/963 - (20%)
• Similarity: 368/963 - (38%)
• Gaps: 240/963 - (24%)

  Fly     3 FVKMISTEASFPLGFILTSLLLAFPGCRGE--RTNVGLVYENTDPDLEKIFHLAISKANEENEDL 65
            |..::|...|..|...|..|:|:....:.|  :..||:|.                .:|....||
plant     4 FHHLVSRFLSLWLLIFLVFLVLSLGKSQKEALQVKVGIVL----------------GSNVTLADL 52

  Fly    66 QLHGVSVSI----EPGNSFET--------SKK---------LCKMLRQNLVAVFGPTSNLAARHA 109
            .|..:::|:    ...|.|:|        ||:         |..:.::.:||:.||.:::.|...
plant    53 SLRAINMSLSEFYNTHNGFKTRIVLNVRDSKQTVVGAAASALYLIKKREVVAIIGPGTSMQAPFL 117

  Fly   110 MSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGV---------ALRDMVVALGWESFTIIYES 165
            :::.:..::|.:    .|.|..|.::....|..:..         |:..::.:..|.....||..
plant   118 INLGNQSKVPII----SFSATSPLLDSLRSPYFIRATHDDSSQVQAISAIIESFRWREVVPIYVD 178

  Fly   166 GEY----LPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLP-- 224
            .|:    ||.:.:..|              |:::...||:.: .:..:||.....:..:.|:|
plant   179 NEFGEGILPNLVDAFQ--------------EINVRIRYRSAI-SLHYSDDQIKKELYKLMTMPTR 228

  Fly   225 ------------EFFKQAQQVGLVTSDYRYIIGN--------------LDWHTMDLEPYQHAGTN 263
                        ..|..|:::.:::..|.:|:.|              ::.|            .
plant   229 VFIVHMLPDLGSRLFSIAKEIDMLSKGYVWIVTNGIADLMSIMGESSLVNMH------------G 281

  Fly   264 ITGLRLVSPDSEQVQEVAKALYESE---EPFQNVSCPLTNSMALVYDGVQLLA---ETYKHVNFR 322
            :.|::.....|:::..: :|.::..   |...|.:|       ..||....||   |..:|||
plant   282 VLGVKTYFAKSKELLHL-EARWQKRFGGEELNNFAC-------WAYDAATALAMSVEEIRHVN-- 336

  Fly   323 PVALSCN--------DDSAWD--------KGYTLVNYMKSLTLNGLTGPIRFDYEGLR---TDFK 368
               :|.|        ||...|        .|..|::.:.:::..|:.|  ||..:..:   |.||
plant   337 ---MSFNTTKEDTSRDDIGTDLDELGVALSGPKLLDALSTVSFKGVAG--RFQLKNGKLEATTFK 396

  Fly   369 LEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVI----TAISEPYG---- 425
              :|.:..||.:.:|.|..:.|.       ..||..|..|..::....|    ..|..|.|
plant   397 --IINIEESGERTVGFWKSKVGL-------VKSLRVDKVSHSSRRLRPIIWPGDTIFVPKGWEFP 452

  Fly   426 ----MLKETSEKLEGNDQF--------------EGFGIELIDELSKKLGFSYTWR-LQEDNKYGG 471
                .|:....|.:|.:.|              .||.|::.:.:..::.::.::. :..|...|
plant   453 TNAKKLRIAVPKKDGFNNFVEVTKDENTNVPTVTGFCIDVFNTVMSQMPYAVSYEYIPFDTPDG- 516

  Fly   472 IDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKL--F 534
             .|: |.::.|:..:.....|..:.|.|:.:.|...|||.:|:..  .||:|..|:|:..:.  :
plant   517 -KPR-GSYDEMVYNVFLGEFDGAVGDTTILANRSHYVDFALPYSE--TGIVFLVPVKDGKEKGEW 577

  Fly   535 SFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGA 599
            .|:.|.:.|:||....:::.:.|.:          |...|...||..|.......::..:||...
plant   578 VFLKPLTKELWLVTAASFLYIGIMV----------WIFEYQADEEFREQMIIDKISSVFYFSFST 632

  Fly   600 LL---QQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGG 661
            |.   ::.||    ::.||.:...|.|..|||..||||.|.:.|||:.|...:...|||  .|.|
plant   633 LFFAHRRPSE----SFFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDDL--RKSG 691

  Fly   662 VNYGAKIGGATFN-----FFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNYAFLMEST 721
            ||.|.:.|..||.     .|.||...||....| ||:  .::..::..|:|       |...|..
plant   692 VNIGYQTGSFTFERLKQMRFDESRLKTYNSPEE-MRE--LFLHKSSNGGID-------AAFDEVA 746

  Fly   722 TIEYITERRCT-LTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRG 785
            .|:....:.|: .:.:.......|:|.|.....|....:|:.:|.:.|...:..::.||:   .|
plant   747 YIKLFMAKYCSEYSIIEPTFKADGFGFAFPLGSPLVSDISRQILNITEGDAMKAIENKWF---LG 808

  Fly   786 GGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVL---GVKER 835
            ...|.|:......:.|:..:...:||::     |.:.|.||.::|   |.:||
plant   809 EKHCLDSTTSDSPIQLDHHSFEALFLIV-----FVVSVILLLLMLASRGYQER 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	79/446 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	95/407 (23%)
GLR2.5	NP_001332219.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	79/453 (17%)
		GluR_Plant	456..806	CDD:270404	90/380 (24%)
		Lig_chan	584..838	CDD:459656	70/287 (24%)