DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GLUR2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001320141.1	Gene:	GLUR2 / 829682	AraportID:	AT4G35290	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	995	Identity:	214/995 - (21%)
Similarity:	389/995 - (39%)	Gaps:	208/995 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MISTEASFPLGFILTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGV 70
            |||..|.....::....:.:....:||.||:.:.....|.:.:..| |..||......|.:.:|
plant    18 MISEGAGLRPRYVDVGAIFSLGTLQGEVTNIAMKAAEEDVNSDPSF-LGGSKLRITTYDAKRNG- 80

  Fly    71 SVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTIN 135
                     |.|.....:.:..:.||:.||.:::.|.....:.:...:|.|    .|.|..|:::
plant    81 ---------FLTIMGALQFMETDAVAIIGPQTSIMAHVLSHLANELSVPML----SFTALDPSLS 132

  Fly   136 -------LHPHPATLGV--ALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTA-GPTVTVRR 190
                   :...|:.|.:  |:.:|:...||.....:|...:   ..|..:    || |..:..||
plant   133 ALQFPFFVQTAPSDLFLMRAIAEMISYYGWSEVIALYNDDD---NSRNGI----TALGDELEGRR 190

  Fly   191 YELDLNGNYR----------------NVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSD 239
            .::    :|:                |.|.:|:..:....:|.....|..:.|::||::|::...
plant   191 CKI----SYKAVLPLDVVITSPREIINELVKIQGMESRVIIVNTFPKTGKKIFEEAQKLGMMEKG 251

  Fly   240 YRYIIGNLDWHTMDLE-----PYQHAGT--NITGLRLVSPDSEQVQE-VAKALYESEEPFQNVSC 296
            |.:|.  ..|.|..|:     |.:.|.:  .:..||:.:|:|::.:: ||:     .....|.:.
plant   252 YVWIA--TTWLTSLLDSVNPLPAKTAESLRGVLTLRIHTPNSKKKKDFVAR-----WNKLSNGTV 309

  Fly   297 PLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDD-----------------SAWDKGYTLVNYM 344
            .|.......||.|.::|...|.:......:|.:.|                 |.:|:|...::|:
plant   310 GLNVYGLYAYDTVWIIARAVKRLLDSRANISFSSDPKLTSMKGGGSLNLGALSIFDQGSQFLDYI 374

  Fly   345 KSLTLNGLTGPIRF--DYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDM- 406
            .:..:.|:||.|:|  |...::..:  ::|.:...|.::||.||...|..   ..|..||...:
plant   375 VNTNMTGVTGQIQFLPDRSMIQPSY--DIINVVDDGFRQIGYWSNHSGLS---IIPPESLYKKLS 434

  Fly   407 -RSLVNKSFVVIT---AISE-PYGML------------------KETSEKLEGNDQFEGFGIELI 448
             ||..|:....:|   ..|| |.|.:                  ||...:|:|:::.:|:.|::.
plant   435 NRSSSNQHLNNVTWPGGTSETPRGWVFPNNGRRLRIGVPDRASFKEFVSRLDGSNKVQGYAIDVF 499

  Fly   449 DELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIP 513
            :...|.:.:.    :..:....|...|...:|..:..:.....|..:.|:.:.::|...||||.|
plant   500 EAAVKLISYP----VPHEFVLFGDGLKNPNFNEFVNNVTIGVFDAVVGDIAIVTKRTRIVDFTQP 560

  Fly   514 FMSLGIGILFRKP---MKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYP 575
            ::..|:.::  .|   :.:.|  ::|:.||:..:|......::.|...:::|......|:..|
plant   561 YIESGLVVV--APVTKLNDTP--WAFLRPFTPPMWAVTAAFFLIVGSVIWILEHRINDEFRGP-- 619

  Fly   576 CIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYST--RAVAASWWFFTLILVSSYTANLAA 638
                |.:     .....||||...:.....|   ...||  |||...|.|..||:.|||||:|.:
plant   620 ----PRK-----QIVTILWFSFSTMFFSHRE---NTVSTLGRAVLLIWLFVVLIITSSYTASLTS 672

  Fly   639 FLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQ 703
            .|||:.|.:||...|.|..:.|.|  |.::|....|:..:.......|:...  .:|:
plant   673 ILTVQQLNSPIRGVDTLISSSGRV--GFQVGSYAENYMIDELNIARSRLVPL--GSPK------- 726

  Fly   704 EGVDRVENSNYAFLMESTTIEYITERR----------CTLTQVGALLDEKGYGIAMRKNWPYRDT 758
                     .||..:::.|:..|.:.|          |.....|......|:|.|..::.|....
plant   727 ---------EYAAALQNGTVAAIVDERPYVDLFLSEFCGFAIRGQEFTRSGWGFAFPRDSPLAID 782

  Fly   759 LSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSD-----ADEDSGAVALEISNLGGVFLVMGVGSF 818
            :|.|:|.:.|.|.|.|:..||.....    ||:     :||||  ..|::.:..|:|||.|:..|
plant   783 MSTAILGLSETGQLQKIHDKWLSRSN----CSNLNGSVSDEDS--EQLKLRSFWGLFLVCGISCF 841

  Fly   819 FGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSS 883
            ..:|:...::|          :..|:....||          ...|..|::|     .|||..:.
plant   842 IALFIYFFKIV----------RDFFRHGKYDE----------EATVPSPESS-----RSKSLQTF 881

  Fly   884 MSVDSLPEDTSEADASGKHN 903
            ::.....||.|:.....|.|
plant   882 LAYFDEKEDESKRRMKRKRN 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	80/406 (20%)
		ANF_receptor	53..374	CDD:279440	73/373 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	91/406 (22%)
		Lig_chan	543..816	CDD:278489	73/289 (25%)
GLUR2	NP_001320141.1	PBP1_GABAb_receptor_plant	31..422	CDD:380645	85/425 (20%)
		GluR_Plant	466..804	CDD:270404	84/379 (22%)
		Lig_chan	590..840	CDD:395014	73/289 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920