DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GLR1.4

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	964	Identity:	194/964 - (20%)
Similarity:	350/964 - (36%)	Gaps:	277/964 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFILTSLLLAFPG----CRG--ERTNVG---LVYENTDPDLEKIFHLAISKANEENEDLQLHGVS 71
            |:.||...|||..    |.|  ::.||.   :|||:..      ..|.:...:.|.: |....:|
plant    10 GYFLTIFFLAFISFAVTCSGTNQKDNVDRLPVVYEDVR------IGLVVDMGSMEGK-LVTTSIS 67

  Fly    72 VSIEP----GNSFETSKKLCKMLRQNLVAVFG------PTSNLAARHAM---------------S 111
            :::..    .|.:.|.           |:|..      |...|||  ||               |
plant    68 MALSDFYHVNNGYRTR-----------VSVLSRDSHGDPLQALAA--AMDLLQTEQVEALVGGQS 119

  Fly   112 ICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDM--------------VVAL----GWES 158
            :.:||.|..|..:    .::|.|:....|::|.:|..:.              :.||    .|.:
plant   120 LLEAKNLAELGEK----TKVPVISSFQVPSSLSLAKYNYFIQATHDTSSEAKGIAALFSNFDWRT 180

  Fly   159 FTIIYESGEYLPTVRELLQ-MYGTAGPTVTVRRY--ELDLNGNYRNVLRRIRNADDFS------F 214
            ..:|||..:   ..||.:| :.|..........|  |..::.|...:::::|.   |.      |
plant   181 AVLIYEDDD---DWRESIQPLVGHFQQNAIHIEYKAEFSVSSNEECIMKQLRK---FKASGIRIF 239

  Fly   215 VVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPY--QHAGTNITGLRLVSPDSEQV 277
            |...|.......|..|:::|::...|.:|:.....:......|  :.....:.|.:...|.:|::
plant   240 VAHISERIANRLFPCARRLGMMEEGYAWILTARSMNNFQDTNYLAKEEMEGVIGFKSYIPLTEEL 304

  Fly   278 QEVA---KALYESEEPFQNVS-C-----PLTNSMA-----------LVYDGVQLLAETYKHVNFR 322
            ....   |.....||....:| |     .:..|:|           .|||.::.:.|:.||
plant   305 HNFTLRWKRSLRLEEVVTRMSVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEAIPESAKH---- 365

  Fly   323 PVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSG 387
                                       .||:|.|:|..:...:| |.|::.:...|.:.:|.|:
plant   366 ---------------------------KGLSGDIKFIDKKFISD-KFEIVNMIGRGERSVGLWN- 401

  Fly   388 EDGFQENRP---APAHSLE-----------PDMRSLVNKSF-------VVITAISEPYGMLKETS 431
            ...|..||.   :...:||           |.:|||..|..       |::     |.|.:  |.
plant   402 SGSFISNRRRRLSSTKALETIIWPGGSTRIPKIRSLKEKRHGKKKKLRVLV-----PAGNI--TP 459

  Fly   432 EKLEGNDQFE-------GFGIELIDELSKKLGFSYTWRLQEDNKY----GGIDPKTGEWNGMLRE 485
            :.||....|:       |:.|::.:  :..|.|:|      :.:|    |.|:.|  .:|.::..
plant   460 QILEVKTDFKTGVTAATGYCIDVFE--TSILPFNY------EVEYIPWPGAINYK--NYNDLVYT 514

  Fly   486 IID--SRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWL 548
            :..  .:.|..:.|:|:|..|...||||:||..:|:.::..|    ...::....|.:..:||.:
plant   515 LYSQKDKYDAAVGDITITDNRSLYVDFTLPFTDMGLAVVTAK----DKSMWIIFKPLTLSLWLTI 575

  Fly   549 GLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAY- 612
            ...::.....::::.|...|::..  .|.::                 ||.||..|......|:
plant   576 ASFFILTGAIVWLIERHDNADFQG--SCFQQ-----------------IGTLLCFGFSTLVFAHR 621

  Fly   613 ------STRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGA 671
                  .:|.|...|.|..|||.|:|||.|.:.:||:.:       ..|..|:....:.|.|...
plant   622 ERLQHNMSRFVVIVWIFAVLILTSNYTATLTSVMTVQQI-------RGLKSNENIGFFSASIAAN 679

  Fly   672 TFNFFKESNYPTYQRMYEFMRDNPQYM-TNTNQEGVDRVENSNYAFLMESTTI----------EY 725
            ..|     :.||:|        .|:|. ..|..:..:.:.|...:|:::....          |:
plant   680 VVN-----DNPTFQ--------GPRYKGLKTADDFTNALRNGTISFIVDEVPYVKLFVAKHPSEF 731

  Fly   726 ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACS 790
            :.....::|        .|:|.|.:|..|....:|:.:.:::....| |....||.:::...|.|
plant   732 VIVETESVT--------NGFGFAFQKGSPLVQKVSREIEKLRRTEKL-KAIENWWFQRQTTSATS 787

  Fly   791 DADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFK 844
               ||: ...|.:....|:|::.||...|.:.|.|:..      ..::.||..|
plant   788 ---EDT-FHPLTVYTFRGLFMITGVSFAFALIVYLIPW------NREQRQVVLK 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	78/430 (18%)
		ANF_receptor	53..374	CDD:279440	72/394 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	81/407 (20%)
		Lig_chan	543..816	CDD:278489	58/290 (20%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	77/425 (18%)
		ANF_receptor	64..390	CDD:279440	69/380 (18%)
		GluR_Plant	448..778	CDD:270404	80/398 (20%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	47/213 (22%)
		Lig_chan	570..810	CDD:278489	59/291 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060