DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and GLR2.7

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	958	Identity:	204/958 - (21%)
Similarity:	376/958 - (39%)	Gaps:	166/958 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FPLGFILTSLLLAFPGCRGE----RTNVGLVYENTDPDLEKIF-HLAISKANEENEDL-QLHG-- 69
            |..||:|      ..||.|:    ...||:|.     ||...| .|.::..|....|. :.|.
plant    20 FVCGFVL------MEGCLGQNQTTEIKVGVVL-----DLHTSFSKLCLTSINISLSDFYKYHSDY 73

  Fly    70 -VSVSIEPGNSFE-----TSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFG 128
             ..::|...:|.|     :|..|..:..:.:.|:.||.:::.|...:.:.|..::|.:    .|.
plant    74 TTRLAIHIRDSMEDVVQASSAALDLIKNEQVSAIIGPRTSMQAEFMIRLADKSQVPTI----TFS 134

  Fly   129 AQLPTINLHPHP----ATLG-----VALRDMVVALGWESFTIIYESGEY----LPTVRELLQMYG 180
            |..|.:.....|    |||.     .|:..:|.:.||.:...||...|:    ||.:.:.||..
plant   135 ATCPLLTSINSPYFVRATLDDSSQVKAIAAIVKSFGWRNVVAIYVDNEFGEGILPLLTDALQDV- 198

  Fly   181 TAGPTVTVRRYELDLNGNYRNVLR---RIRNADDFSFVVVGSMATLP-----EFFKQAQQVGLVT 237
               ....|.|..:....|...:|:   ::.......|||     .:|     .||::|:::|::.
plant   199 ---QAFVVNRCLIPQEANDDQILKELYKLMTMQTRVFVV-----HMPPTLGFRFFQKAREIGMME 255

  Fly   238 SDYRYIIGNLDWHTMDLEPYQHAGTN------ITGLRLVSPDSEQVQEVAKALYESEEPFQNVSC 296
            ..|.:::.:   ..|:|......|::      :.|:|...|.|::::.. :..:|...|.:....
plant   256 EGYVWLLTD---GVMNLLKSNERGSSLENMQGVLGVRSHIPKSKKLKNF-RLRWEKMFPKKGNDE 316

  Fly   297 PLTNSMAL-VYDGVQLLAETYKHVNFR------PVALSCNDDSAWDKGY-----TLVNYMKSLTL 349
            .: |..|| .||.:..||...:..|.:      |:|...|..:....|.     :|:..:.::..
plant   317 EM-NIFALRAYDSITALAMAVEKTNIKSLRYDHPIASGNNKTNLGTLGVSRYGPSLLKALSNVRF 380

  Fly   350 NGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHS---------LEPD 405
            |||.|.... ..|.......:||.:..|..:.||.|...:|....:.....|         :.|.
plant   381 NGLAGEFEL-INGQLESSVFDVINIIGSEERIIGLWRPSNGIVNAKSKNTTSVLGERLGPVIWPG 444

  Fly   406 MRSLVNKSFVVIT-------AISEPYGMLKETSEKLEGNDQF---EGFGIELIDELSKKLGFS-- 458
            ....|.|.:.:.|       .|....|.|:....|::.....   .|:.||:.:.:.|||.:|
plant   445 KSKDVPKGWQIPTNGKMLRVGIPVKKGFLEFVDAKIDPISNAMTPTGYCIEIFEAVLKKLPYSVI 509

  Fly   459 --YTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGI 521
              |...|..|..|          :.|:.::.....|..:.|:|:.:.|...||||:|:...|:.:
plant   510 PKYIAFLSPDENY----------DEMVYQVYTGAYDAVVGDVTIVANRSLYVDFTLPYTESGVSM 564

  Fly   522 LFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQ 586
            :.  |:|:....:.|:.|:|.::|:.....::.:...:::|......::..|           ..
plant   565 MV--PLKDNKNTWVFLRPWSLDLWVTTACFFVFIGFIVWILEHRVNTDFRGP-----------PH 616

  Fly   587 FSFANCLWFSIGALLQQGSELAPKAYS--TRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPI 649
            .......||:...:.....|   |..|  .|.|...|.|..|:|:.||||||.:|.||:.|...:
plant   617 HQIGTSFWFAFSTMNFAHRE---KVVSNLARFVVLVWCFVVLVLIQSYTANLTSFFTVKLLQPTV 678

  Fly   650 NDADDLSK-NKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSN 713
            .:..||.| ||   |.|.:.|.......|...:           |..|.....:....|.: .||
plant   679 TNWKDLIKFNK---NIGYQRGTFVRELLKSQGF-----------DESQLKPFGSAVECDEL-FSN 728

  Fly   714 YAFLMESTTIEYI----TERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTK 774
            .........:.||    ::.....|.|.......|:|....|..|..|.:|:|:|.:.:...:..
plant   729 GTITASFDEVAYIKVILSQNSSKYTMVEPSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQH 793

  Fly   775 MKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKER-SDE 838
            ::.||:::...   |.|.:....:..|.:|:..|:||:.|:.||..:.:.:...:...|.. .|:
plant   794 IENKWFKKPNN---CPDLNTSLSSNHLSLSSFWGLFLIAGIASFLALLIFVANFLYEHKHTLFDD 855

  Fly   839 NQVSFKTELLDEIRFILQCSGNTKAVK---YPKNSSRSNASSKSKGSS 883
            ::.||:.:|    :|::: :.:.|.:|   :.:|:..:.:|..::|||
plant   856 SENSFRGKL----KFLVR-NFDEKDIKSHMFKENAVHNVSSPITQGSS 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	84/402 (21%)
		ANF_receptor	53..374	CDD:279440	75/368 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	85/390 (22%)
		Lig_chan	543..816	CDD:278489	60/279 (22%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	85/404 (21%)
		ANF_receptor	54..405	CDD:279440	75/369 (20%)
		GluR_Plant	460..799	CDD:270404	82/379 (22%)
		Lig_chan	584..832	CDD:278489	60/279 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.070