DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GLR2.8

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	889	Identity:	180/889 - (20%)
Similarity:	346/889 - (38%)	Gaps:	184/889 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VGLVYE-NTDPDLEKI----FHLAISKANEENED----LQLHGVSVSIEPGNSFETSKKLCKMLR 91
            ||:|.: ||  ...||    .:||:|...:::.:    |.|| |..|::  ::.:.|.....:::
plant    36 VGVVLDLNT--TFSKICLTSINLALSDFYKDHPNYRTRLALH-VRDSMK--DTVQASAAALDLIQ 95

  Fly    92 QNLV-AVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTI-NLHPHPATLGV--------A 146
            ...| |:.||..::.|:..:.:.:..::|.:    .|.|..|.: ::.......|.        |
plant    96 NEQVSAIIGPIDSMQAKFMIKLANKTQVPTI----SFSATSPLLTSIKSDYFVRGTIDDSYQVKA 156

  Fly   147 LRDMVVALGWESFTIIY---ESGE-YLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLR--- 204
            :..:..:.||.|...||   |.|| .:|.:.:.||       .|.|.|..:....|...:|:
plant   157 IAAIFESFGWRSVVAIYVDNELGEGIMPYLFDALQ-------DVQVDRSVIPSEANDDQILKELY 214

  Fly   205 RIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTN------ 263
            ::.......|||..:.......|::|.::|::...|.:::.|...|.|   .:.|.|.:
plant   215 KLMTRQTRVFVVHMASRLASRIFEKATEIGMMEEGYVWLMTNGMTHMM---RHIHHGRSLNTIDG 276

  Fly   264 ITGLRLVSPDSEQVQEVA---KALYESEEPFQNVSCPLTNSMAL----VYDGVQLLAETYKHVNF 321
            :.|:|...|.|:.:::..   |..::.|.|:      |.:.:::    .||....||...:..|.
plant   277 VLGVRSHVPKSKGLEDFRLRWKRNFKKENPW------LRDDLSIFGLWAYDSTTALAMAVEKTNI 335

  Fly   322 RPVALSCNDDSAWDK-------------GYTLVNYMKSLTLNGLTGPIRFDYEGLRTDF-KLEVI 372
            .  :...|:.|....             |.:|:..:..:..|||.|  ||:....:.:. |.|:|
plant   336 S--SFPYNNASGSSNNMTDLGTLHVSRYGPSLLEALSEIRFNGLAG--RFNLIDRQLESPKFEII 396

  Fly   373 ELAVSGMQKIGQWSGEDG-----------FQENRPAPAHSLEPDMRSLVNKSFVVIT-----AIS 421
            ....:..:.:|.|:..:|           |...|..|.  :.|...::|.|.:.:.|     .:.
plant   397 NFVGNEERIVGFWTPSNGLVNVNSNKTTSFTGERFGPL--IWPGKSTIVPKGWEIPTNGKKIKVG 459

  Fly   422 EP-----YGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFS-----YTWRLQEDNKYGGIDPKT 476
            .|     :..::..::.:......:|:.|::.:...|||.:|     |.:...:|
plant   460 VPVKKGFFNFVEVITDPITNITTPKGYAIDIFEAALKKLPYSVIPQYYRFESPDD---------- 514

  Fly   477 GEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFS 541
             :::.::.::.:...|..:.|:|:|:.|....|||:|:...|:.::......|....:.|:.|:.
plant   515 -DYDDLVYKVDNGTLDAVVGDVTITAYRSLYADFTLPYTESGVSMMVPVRDNENKNTWVFLKPWG 578

  Fly   542 GEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSE 606
            .::|:.....::.:...:::.......::..|           .........|||...::....|
plant   579 LDLWVTTACFFVLIGFVVWLFEHRVNTDFRGP-----------PHHQIGTSFWFSFSTMVFAHRE 632

  Fly   607 LAPKAYS--TRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNY--GA- 666
               |..|  .|.|...|.|..|:|..||||||.:||||:.......:..||.||...|.|  ||
plant   633 ---KVVSNLARFVVVVWCFVVLVLTQSYTANLTSFLTVQRFQPAAINVKDLIKNGDYVGYQHGAF 694

  Fly   667 ------KIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNYAFLMESTTIEY 725
                  |.|   ||..|...:.:.:..:..:                    ||.:.   |...:.
plant   695 VKDFLIKEG---FNVSKLKPFGSSEECHALL--------------------SNGSI---SAAFDE 733

  Fly   726 ITERRCTLTQ-------VGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEK 783
            :...|..|:|       |.......|:|.|..:|.|....:|:|:|.:.:...:..::.||:.::
plant   734 VAYLRAILSQYCSKYAIVEPTFKTAGFGFAFPRNSPLTGDVSKAILNVTQGDEMQHIENKWFMKQ 798

  Fly   784 RGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFG--IFVSL 825
            ..   |.|......:..|.:.:..|:||:.|:.||..  |||.|
plant   799 ND---CPDPKTALSSNRLSLRSFWGLFLIAGIASFLALLIFVFL 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	83/417 (20%)
		ANF_receptor	53..374	CDD:279440	74/368 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	78/402 (19%)
		Lig_chan	543..816	CDD:278489	61/290 (21%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	84/411 (20%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	75/391 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.070