DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GLR2.3

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001325281.1	Gene:	GLR2.3 / 817007	AraportID:	AT2G24710	Length:	919	Species:	Arabidopsis thaliana

Alignment Length:	960	Identity:	205/960 - (21%)
Similarity:	363/960 - (37%)	Gaps:	219/960 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLLAFPGC----RGER-----TNVGLVYENTDPDL--EKIFHLAISKANEENEDLQLHGVSVSIE 75
            :||.|..|    ||:.     .:||:|   ||.|.  .|:..|.|:.:           :|....
plant    34 ILLVFFFCLEFNRGQNNGKTLVDVGVV---TDVDTSHSKVVMLCINMS-----------ISDFYS 84

  Fly    76 PGNSFET--------SKK---------LCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDT 123
            ....|||        ||.         |..:..:.:.|:.||.:::.|...:.|.....:|.:
plant    85 SNPQFETRLVVNVGDSKSDVVGAAIAALDLIKNKQVKAILGPWTSMQAHFLIEIGQKSRVPIV-- 147

  Fly   124 RWDFGAQLPTINLHPHPATLGVALRD---------MVVALGWESFTIIYESGEY----LPTVREL 175
              .:.|..|.:.....|..|.....|         ::...||.....:|....:    :|.:.:.
plant   148 --SYSATSPILTSLRSPYFLRATYEDSFQVQPIKAIIKLFGWREVVPVYIDNTFGEGIMPRLTDA 210

  Fly   176 LQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSF-VVVGSMATLP--------------E 225
            ||              ::::...||:|:  ..||.|... |.:..|..:|              .
plant   211 LQ--------------DINVRIPYRSVI--AINATDHEISVELLKMMNMPTRVFLVHMYYDLASR 259

  Fly   226 FFKQAQQVGLVTSDYRYIIGN--LDWHTMDLEPYQHAGTNITGLRLV---SPDSEQVQEVAKALY 285
            ||.:|:::||:...|.:|:.|  :|..::..|....|...:.|::..   |||.|:.:...::|:
plant   260 FFIKAKELGLMEPGYVWILTNGVIDDLSLINETAVEAMEGVLGIKTYIPKSPDLEKFRSRWRSLF 324

  Fly   286 ESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDK-----------GYT 339
            ...|        |:......||....||...:......:..|...|:..:.           |..
plant   325 PRVE--------LSVYGLWAYDATTALAVAIEEAGTNNMTFSKVVDTGRNVSELEALGLSQFGPK 381

  Fly   340 LVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLE- 403
            |:..:.::...||.|..|| :.|.......|::.:..:|.:.||.|...:|..:.....|.|:.
plant   382 LLQTLLTVQFRGLAGEFRF-FRGQLQPSVFEIVNIINTGEKSIGFWKEGNGLVKKLDQQASSISA 445

  Fly   404 -------------PDMRSLVNKSFVVIT-----AISEP-----YGMLKETSEKLEGNDQFEGFGI 445
                         |.....|.|.:.:.|     .|..|     ..::|.|.:.:..:....||.|
plant   446 LSTWKDHLKHIVWPGEADSVPKGWQIPTKGKKLRIGVPKRTGYTDLVKVTRDPITNSTVVTGFCI 510

  Fly   446 ELIDELSKKLGFSYTWRLQEDNKYGGIDPKT-GEWNGMLREIIDSRADMGITDLTMTSERESGVD 509
            :..:.:.::|.:..::......|..|   || |.:|.::.::...|.|..:.|.|:...|.|.||
plant   511 DFFEAVIRELPYDVSYEFIPFEKPDG---KTAGNYNDLVYQVYLGRYDAVVGDTTILVNRSSYVD 572

  Fly   510 FTIPFMSLGIGILFRKPMKEPPK--LFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDN 572
            ||.||:..|:|::..  |.:|.|  ...||.|.|.::||...:::..|..:::||......::..
plant   573 FTFPFIKSGVGLIVE--MTDPVKRDYILFMKPLSWKLWLTSFISFFLVGCTVWVLEYKRNPDFSG 635

  Fly   573 PYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPK----AYSTRAVAASWWFFTLILVSSYT 633
            |           .:|..:...||:...::     .||:    ::..||:..:|:|..|:|..|||
plant   636 P-----------PRFQASTICWFAFSTMV-----FAPRERVFSFWARALVIAWYFLVLVLTQSYT 684

  Fly   634 ANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNF----FKESNYP--------TYQR 686
            |:||:.||.:.|...|.....|      :..|..:|....:|    .||..:|        |.:.
plant   685 ASLASLLTSQKLNPTITSMSSL------LEKGETVGYQRTSFILGKLKERGFPQSSLVPFDTAEE 743

  Fly   687 MYEFMRDNPQYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRC-TLTQVGALLDEKGYGIAMR 750
            ..|.:...|:      :.||      :.||| |...:.....:.| |...|....:..|:|....
plant   744 CDELLSKGPK------KGGV------SGAFL-EIPYLRLFLGQFCNTYKMVEEPFNVDGFGFVFP 795

  Fly   751 KNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSD----ADEDSGAVA--LEISN---- 805
            ...|....:|:|:|::.|.....:::..|:::|.  .:|.|    .|.:....:  |:|.:
plant   796 IGSPLVADVSRAILKVAESPKAMELERAWFKKKE--QSCPDPITNPDPNPSFTSRQLDIDSFLFL 858

  Fly   806 LGGVFL--VMGVGSFFGIF-----VSLLEMV-LGVKERSDENQVSFKTEL 847
            ..||.|  ||.:|:|...|     ||.|:.| :.....|.:..|..||:|
plant   859 FVGVLLVCVMALGNFTYCFLAKDQVSYLDKVEMSPCSSSQQMPVKRKTQL 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	79/416 (19%)
		ANF_receptor	53..374	CDD:279440	69/381 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	91/399 (23%)
		Lig_chan	543..816	CDD:278489	65/301 (22%)
GLR2.3	NP_001325281.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070