DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and grik5

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	891	Identity:	306/891 - (34%)
Similarity:	490/891 - (54%)	Gaps:	101/891 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RGERTNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNL 94
            ||||..:.|..||.:..:|.     .::|..|.:..:|       :..:.:||:..:|::|.:.:
Zfish    51 RGERLALALARENINSVMEN-----PARARVEVDIFEL-------QKDSQYETTDTMCQILPKGV 103

  Fly    95 VAVFGPTSNLAARHAMS-ICDAKELPFLDTRWDFGAQLP-----TINLHPHPATLGVALRDMVVA 153
            |:|.||.|:.|:...:| ||..||:|.:....:...:||     ::.|:|....|.:|:..::.:
Zfish   104 VSVIGPASSPASGSIVSHICGEKEIPHVKIGPEETPRLPYLRFASVTLYPSNEDLSLAIGSILRS 168

  Fly   154 LGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVG 218
            ..:.|.:::....|.|..:.||::.:..:..|:::|.  ||.|.:...:|:.||: |..:.:::.
Zfish   169 FSYPSASLVCAKAECLLRLEELIRRFLISRETLSIRM--LDDNLDPTPLLKEIRD-DKIATIIID 230

  Fly   219 SMATLPE-FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK 282
            :.|::.. ..|:|.::|:.::.|:||:..:|:..:.|:......:||.|.
Zfish   231 ANASISYLILKKASELGMTSAFYKYILTTMDFPLLWLDDIVDEQSNIVGF--------------- 280

  Fly   283 ALYESEEPFQ-------NVS----CPLTN------SMALVYDGVQLLAETYKHVN------FRPV 324
            :::.:..||.       |:|    |.:..      |.||::|.|.::....:.:|      .:|
Zfish   281 SMFNTTHPFYLEFIRSLNLSWREGCDINPYPGPALSSALLFDAVHVVVSAVQELNRSQEIGVKP- 344

  Fly   325 ALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGED 389
             |||.....|..|.:|:||::.:..:||||.:.|:.:|.||::.|.::|....|.::||.|...:
Zfish   345 -LSCTSPQIWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLHILEKHRGGHKEIGIWYSNN 408

  Fly   390 GFQENRPAPAHSLEPDM-RSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSK 453
            ....|    :.||:.:: .:|.|||.::.|.:..||.|.|...::.|||:|:|||.::::.|||.
Zfish   409 TLLMN----STSLDINVSETLANKSLIITTILENPYVMRKINYQEFEGNEQYEGFCVDMLRELSD 469

  Fly   454 KLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLG 518
            .|.|:|..:|.:|..||..:| .|.|.||:.|:|:.:||:.:...|:|||||..:||:.|||:||
Zfish   470 ILKFTYRIKLVDDGLYGAPEP-NGSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFMTLG 533

  Fly   519 IGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTE- 582
            |.||:|..:...|..|||:.|||..|||::.|||:.||..:|:..||||.||.||:||:.|..:
Zfish   534 ISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYNPHPCLRERRDL 598

  Fly   583 LENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVT 647
            ||||::..|.|||.:|..:|||||:.|:|.|||.|:..||.||||::|||||||||||||:.:..
Zfish   599 LENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEV 663

  Fly   648 PINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFM-RDNPQYMTNTNQEGVDRVEN 711
            ||...|||: ::..:.||...||:|..||..|.|.|||||:.:| ...|.....:.:||:.||.|
Zfish   664 PIESPDDLA-DQTNIQYGTIHGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVVN 727

  Fly   712 SNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMK 776
            |.||||:|||..||.....|.|||:|.|||.|||||.|....|:||.||.|||::||...|..:|
Zfish   728 SKYAFLLESTMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILK 792

  Fly   777 TKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQ- 840
            .:||:    ||.| ..:||..|..|.:.|:||:|:|:..|....:||:::|.|...:..::.::
Zfish   793 RRWWE----GGKC-PKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFVWSTRRSAETDEV 852

  Fly   841 --------------VSFKTELLDEIRFILQCSGNTKAVKYPKNSSR 872
                          ||...|:|.|.|..:.|          |.|||
Zfish   853 RPLSCDRQYHSHTTVSVCQEMLTEFRNAVSC----------KKSSR 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	89/383 (23%)
		ANF_receptor	53..374	CDD:279440	80/350 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	180/371 (49%)
		Lig_chan	543..816	CDD:278489	135/274 (49%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	93/392 (24%)
		ANF_receptor	55..392	CDD:279440	84/368 (23%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	21/71 (30%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	180/371 (49%)
		Lig_chan	558..828	CDD:278489	135/275 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760