DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and gria1a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	935	Identity:	293/935 - (31%)
Similarity:	474/935 - (50%)	Gaps:	97/935 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTSLLLAFPG-CRG----ERTNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVS-IEPG 77
            ||.|..:|.| |.|    ...|:|.::.....:.| :|..|:|    .::|:......|. ::.|
Zfish     5 LTLLCTSFLGLCFGSSFPSNINIGGLFPTESHEYE-VFRFALS----HHQDIPKLVPQVDMVKLG 64

  Fly    78 NSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPAT 142
            |||..:...|....:.:.|:.|..........||.|.|..:.|:.      ...|..|.:.....
Zfish    65 NSFSMTYAFCSQFSKGVYAIIGVYDRKTVNMLMSFCGALHVCFVT------PSFPMENSNQFVIQ 123

  Fly   143 LGVALRDMVVAL----GWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVL 203
            |...|:|.:|.:    .|..|..:|.|...|..::::|.........||....|.....::..|.
Zfish   124 LRPELQDALVGVIEHYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFLKVF 188

  Fly   204 RRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLR 268
            :.:....:...::...:..|....|:..::|.....|.||:.||.:..:||..::....|:||.:
Zfish   189 QDLDKKKEGQIIIDCELERLTSILKKIIELGKNVKSYHYILANLGFLDIDLTEFKKGEANVTGFQ 253

  Fly   269 LVSPDSEQVQEVAKALYESEEPFQNVSCP---LTNSMALVYDGVQLLAETYKHVNFRPVALS--- 327
            ||:.....|....:...|.:.  ::...|   |..:.||.||||::::..::::..:.:.:|
Zfish   254 LVNYADPNVSRTVQQWMEFDN--KDAKVPKRRLKYTGALTYDGVKVMSTAFQNLRRQRIDISRRG 316

  Fly   328 ------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWS 386
                  .|..:.|.:|..:...::.:.:.||||.|:|:.:|.||::.:.|:||..:|.:|:|.|:
Zfish   317 NAGECLANPPAPWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVMELRPTGPKKVGYWN 381

  Fly   387 GEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDEL 451
            .::.|.........|.|  ...|.|::::|.|.:..||.|||:..|...|||::||:.:||..|:
Zfish   382 EDEKFVSTAAYMPGSNE--TYGLQNRTYIVTTILESPYVMLKKNHEHFTGNDKYEGYCVELAAEI 444

  Fly   452 SKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMS 516
            :|.:|:.|..::..|.|||..|.:|..||||:.|::..:||:.:..||:|..||..:||:.||||
Zfish   445 AKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMS 509

  Fly   517 LGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEW----------D 571
            |||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.|.||.||          :
Zfish   510 LGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDCEDGAEE 574

  Fly   572 NPYPCIEEPT------------------ELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVA 618
            ||    .:|:                  |..|:|...|.||||:||.:|||.:::|::.|.|.|.
Zfish   575 NP----NQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 635

  Fly   619 ASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPT 683
            ..|||||||::||||||||||||||.:|:||..|:||:| :..:.||....|:|..||:.|....
Zfish   636 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTEIAYGTLDAGSTKEFFRRSKIAV 699

  Fly   684 YQRMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKG 744
            :::|:.:|:. :|.....|..|||.||..|  .||:|:|||..|||.:|: |...:||..||.||
Zfish   700 FEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG 764

  Fly   745 YGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDS--GAVALEISNLG 807
            ||||..|..|.|:.::.|||::.|||||.|:|.|||.:|   |.|.....||  ...||.:||:.
Zfish   765 YGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSNVA 826

  Fly   808 GVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIR--FILQCSGNTKAVK----- 865
            |||.::..|....:.|:|:|..  .|.|::..::  |..:.|.:.  .:.:.|||....:
Zfish   827 GVFYILIGGLGLAMLVALVEFC--YKSRTESRRM--KQSINDAMHCSTLTRMSGNGSGGENGRIV 887

  Fly   866 ---YPKN----SSRSNASSKSKGSS 883
               :||.    ...|:|:|...|:|
Zfish   888 THDFPKAVQTLPCMSHAASMGLGAS 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	80/370 (22%)
		ANF_receptor	53..374	CDD:279440	71/337 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	170/401 (42%)
		Lig_chan	543..816	CDD:278489	127/306 (42%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	81/373 (22%)
		ANF_receptor	36..369	CDD:279440	73/345 (21%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	173/409 (42%)
		Lig_chan	536..836	CDD:278489	127/307 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850