DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grik1a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	868	Identity:	319/868 - (36%)
Similarity:	490/868 - (56%)	Gaps:	68/868 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VGLVYENTDPDL----EKIFHLAISKANEENEDLQLHGVSVSIEPGN---SFETSKKLCKMLRQN 93
            :|.::|..:.:.    |..|..|::..|.....:....::..|:..|   |||.|:::|..|...
Zfish    41 IGGIFETRENEPVSMDELAFKFAVTSINRNRTLMPNTTLTYDIQRVNLFDSFEASRRVCDQLALG 105

  Fly    94 LVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPT--------INLHPHPATLGVALRDM 150
            :.|||||:.:.:.....|||:|.|:|.:.|||    :.|:        |||:|...::..|:.|:
Zfish   106 VAAVFGPSHSSSVSAVQSICNALEVPHIQTRW----KHPSVDNKDNFYINLYPEYTSISRAILDI 166

  Fly   151 VVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFV 215
            |:...|:..|::||....|..::||::........:.:|:.... .|:.|.:|:.::...:|..:
Zfish   167 VIFYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKIRIRQLPSG-GGDSRPLLKEMKKEKEFYVI 230

  Fly   216 VVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEV 280
            ...|.....|..||...:|::|..|.:....||...:|||||:::|.|:|..||::.|...|..|
Zfish   231 FDCSYQVAAELLKQLMSMGMMTEYYHFFFTTLDLFALDLEPYRYSGVNMTAFRLLNLDDSYVASV 295

  Fly   281 ------AKALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPV-ALSCNDDSAWDKGY 338
                  .:.|...:.....:|..:|.:.||:||.|.::|...:......| :|.|:....|..|.
Zfish   296 IQKWSMERQLAPPKPESGLMSGIMTTAAALMYDAVFMVAVASQRATQMTVSSLQCHRHKPWRYGP 360

  Fly   339 TLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLEVIELAVSG---------------MQKIGQWSG 387
            ..:|..|....:||||.|..: .:|||.:|.|::|.|...|               ..|||.|:.
Zfish   361 RFMNLFKEAQWDGLTGRIVLNKTDGLRKEFNLDLISLKEDGTAKRVADGASRPNKLWTKIGVWNS 425

  Fly   388 EDG-----FQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIEL 447
            ..|     .::|:..        ..||.|::.:|.|.:..||.|.|::.:.|.|||:|||:.::|
Zfish   426 YTGLNLTEIKDNKNI--------TDSLANRTLIVTTILENPYVMYKKSDKVLYGNDRFEGYCLDL 482

  Fly   448 IDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTI 512
            :.|||..|||:|..:|..|.|||..:.| ||||||:||:||..||:.:..||:|..||..:||:.
Zfish   483 LKELSNILGFTYEVKLVTDGKYGAQNDK-GEWNGMVRELIDHIADLAVAPLTITYVREKVIDFSK 546

  Fly   513 PFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCI 577
            |||:|||.||:|||....|.:|||::|.:.::|:::.||.:|||..:||:.|.:|.||.||:||.
Zfish   547 PFMTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCN 611

  Fly   578 EEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTV 642
            .....:||.|:..|.|||.:.||::|||||.|||.|||.:...|||||||::|||||||||||||
Zfish   612 PSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLIIISSYTANLAAFLTV 676

  Fly   643 ESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFM--RDNPQYMTNTNQEG 705
            |.:.:||:.||||:| :..:.|||...|:|..|||:|...||::|:.||  |.|...:.| :::|
Zfish   677 ERMDSPIDSADDLAK-QTRIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRKNTALVKN-SKDG 739

  Fly   706 VDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQG 770
            :.||..::||.|||||:|||||:|.|.|||||.|:|.||||:......||||.::.|:|::||:|
Zfish   740 ITRVLTTDYALLMESTSIEYITQRNCNLTQVGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEG 804

  Fly   771 LLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKER 835
            .|..||.|||   ||.| |.:.|... |.||.:.|:||:|:|:..|....:||::.|.:....:.
Zfish   805 KLHMMKEKWW---RGNG-CPEEDSKE-ASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSHKN 864

  Fly   836 SD-ENQVSFKTELLDEIRFILQC 857
            || |..||| :.:::::...|:|
Zfish   865 SDIEECVSF-SAVMEDLGISLRC 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	104/396 (26%)
		ANF_receptor	53..374	CDD:279440	93/339 (27%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	186/371 (50%)
		Lig_chan	543..816	CDD:278489	137/274 (50%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	104/395 (26%)
		ANF_receptor	57..398	CDD:279440	95/345 (28%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	187/374 (50%)
		Lig_chan	577..846	CDD:278489	137/275 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760