DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grid1a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	890	Identity:	257/890 - (28%)
Similarity:	422/890 - (47%)	Gaps:	118/890 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILTSLLLAFPGCRGERT----NVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVS---IE 75
            ::.||.|....||..|.    ::|.::|......:::|.||||..:..::.||...::.|   ||
Zfish     4 LVISLSLWILQCRSARADSIIHIGAIFEQNAIRDDEVFQLAISDLSLNDDILQSERITHSIKLIE 68

  Fly    76 PGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELP--FLDTRWDFGAQLPTINLHP 138
            |.|.|:..::.|:::.|.::|:...|...||....|:.||..:|  |:....| |.......|:|
Zfish    69 PNNPFQAVQEACELMNQGILALVSSTGCAAANALQSLTDAMHIPHLFIQRNGD-GTPRAECQLNP 132

  Fly   139 HP--------ATLGVALRDMVVA----LGWESFTIIYESGEYLPTVRELLQMYGTAGPTV----- 186
            .|        |...|.|.|:::.    |.|..|.:.|:|...:..:|..|......|..|
Zfish   133 SPDGERYTLAARPPVRLNDVMITLVSELRWHKFIVFYDSEYDVRGLRGFLDQASRMGLDVSLQQV 197

  Fly   187 -------------TVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTS 238
                         |:|..||:   .||:.|||.        :::.|..|...|..||.:..|.:.
Zfish   198 DRNVTKVFSTLFSTMRMEELN---RYRDTLRRA--------ILLLSPRTAQVFIHQAVETNLASK 251

  Fly   239 DYRYIIGNLDWHTMDLEPYQHAGT-NITGLRLVSP---DS-----EQVQEVAKALYESEEPFQNV 294
            |..::..|.:....::....|:.. .:|.:|.:.|   |:     .....::..|.:.:|.:..
Zfish   252 DSHWVYANEEVSDTEIMELVHSALGRMTVIRQIFPLWRDTNIRCMRNNHRISSLLCDPQEGYLQ- 315

  Fly   295 SCPLTNSMALVYDGVQLLAET-YKHVNFRP----VALSCNDDSA--WDKGYTLVNYMKSLTLNGL 352
              .|..|...:||.|.:||.. |:.:..|.    .:|:|...|.  |:.|:::::.::...::||
Zfish   316 --SLEVSSLYLYDSVLMLANAFYRKLEDRKWHSMASLNCMRKSTKPWNGGWSMLDTIQKGRISGL 378

  Fly   353 TGPIRFDYEGLRTDFKLEVIELAVS-----GMQKIGQWSGEDG----FQENRPAPAHSLEPDMRS 408
            ||.:.|...|..:..:.|::..:.|     .::::..|..:.|    .:|||      .:..|:.
Zfish   379 TGLMDFRSNGANSHVQFEILGTSYSETFGKDVKRLATWDSDRGLNGSLRENR------ADHGMQG 437

  Fly   409 LVNKSFVVITAISEPYGMLKETSEKLEGN-DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGI 472
            :..|   |:|.:.||:.|:   :|.:.|. .:::||.|:::|.|:|.|||.|......|.|||
Zfish   438 ITLK---VVTLLEEPFVMV---AENILGQPKRYKGFSIDVLDALAKILGFKYEMYQVADAKYG-- 494

  Fly   473 DPKT-GEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSF 536
            .|:| |.||||:.|:|..|||:.|:.:|:|.|||:.|||:..::...:|||..| .:|...:||.
Zfish   495 SPQTNGSWNGMIGELIGKRADVAISAITITPERENVVDFSKRYLDYSVGILMTK-TEERLNIFSL 558

  Fly   537 MSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALL 601
            ::||...||..:..|...|.:.:|:|.|:......|| |...:|..:..  ||.:.:|...||.:
Zfish   559 LAPFDLAVWACIAAAIPVVGVMVFLLRRVQSVRSQNP-PGPHQPASVTT--SFQSAIWIVYGAFV 620

  Fly   602 QQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGA 666
            |||.|....:.:.|....|||.||||:.|||||||||:|||..:...|....|||| :..:|||.
Zfish   621 QQGGESFMSSMALRIAMGSWWLFTLIVCSSYTANLAAYLTVSRMDNAIRTFQDLSK-QSEINYGT 684

  Fly   667 KIGGATFNFFK-ESNYP-----TYQRMYEFMRDNPQYMTN---TNQEGVDRVENSNYAFLMESTT 722
            ....|.|.:|: :...|     |:..::..:..| |...|   :..||:.:|:...||||.:...
Zfish   685 VRESAVFEYFRVKGTNPLEQDSTFAELWRTINKN-QGQDNSVTSPAEGIRKVKRDPYAFLWDMAV 748

  Fly   723 IEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRG 785
            :||  :|:..|||...|..:..||||:|::...||||..||.:|::||:|.|..:|.|||..|
Zfish   749 LEYAALTDDDCTLVVTGNGMSSKGYGLALQHGSPYRDLFSQKILDLQEKGDLDILKQKWWPRK-- 811

  Fly   786 GGAC---SDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLE 827
             |.|   ..|:..:...||.:.:..|||.::..|......|:.||
Zfish   812 -GRCDLDKHAEPQTEGRALRLHSFAGVFCILAAGLLLACLVAALE 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	92/413 (22%)
		ANF_receptor	53..374	CDD:279440	86/371 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	141/382 (37%)
		Lig_chan	543..816	CDD:278489	99/286 (35%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	92/413 (22%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	141/385 (37%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591113
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840