Protein Alignment Grik and Grid2

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 929
• Identity: 250/929 - (26%)
• Similarity: 438/929 - (47%)
• Gaps: 154/929 - (16%)

  Fly    13 FPLGFILT-------------SLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENED 64
            |||.|.|:             |::           ::|.:::.:....:::|..|:...|:..|.
  Rat     4 FPLLFFLSFWWSRTWDLATSDSII-----------HIGAIFDESAKKDDEVFRTAVGDLNQNEEI 57

  Fly    65 LQLHGVSVS---IEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFL----- 121
            ||...::.|   ::..|.|:..::.|:::.|.::|:.......:|....|:.||..:|.|
  Rat    58 LQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRS 122

  Fly   122 --------------DTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTV 172
                          :...|:     |:::.| |..|...:..:|....|:.|.|.|:|...:..:
  Rat   123 TAGTPRSGCGLTRSNRNDDY-----TLSVRP-PVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGI 181

  Fly   173 RELLQMYGTAGPTVTVRRYELDLN---------------GNYRNVLRRIRNADDFSFVVVGSMAT 222
            :|.|......|..|.:::.|.::|               ..||:.|||.        ::|.:.||
  Rat   182 QEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRA--------ILVMNPAT 238

  Fly   223 LPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDL-EPYQHAGTNITGLRLVSPDSEQVQE------- 279
            ...|..:..:..||..|..:||.|.:.:.:|: |..:.:...:|.:|...|..:.:.:
  Rat   239 AKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNH 303

  Fly   280 -VAKALYESEEPF-QNVSCPLTNSMALVYDGVQLLAETY-KHVNFRP----VALSC--NDDSAWD 335
             ::..|.:.::|| ||:..    |...:||.|.|||..: |.:..|.    .:|||  .:...|.
  Rat   304 RISSTLCDPKDPFAQNMEI----SNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQ 364

  Fly   336 KGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVI------ELAVSGMQKIGQWSGEDGFQEN 394
            .|.:::..:|...:|||||.:.|...|...:...|::      ||. .|::|:|.|:...|.  |
  Rat   365 GGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELG-RGVRKLGCWNPVTGL--N 426

  Fly   395 RPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGN-DQFEGFGIELIDELSKKLGFS 458
            .......||.:||.:|.:   |:|.:.||:.|:   ||.:.|. .:::||.|:::|.||..|||:
  Rat   427 GSLTDKKLENNMRGVVLR---VVTVLEEPFVMV---SENVLGKPKKYQGFSIDVLDALSNYLGFN 485

  Fly   459 YTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF 523
            |...:..|:|||. ..:.|.|||::.|::..|||:||:.||:|.:||:.||||..:|...:|:|.
  Rat   486 YEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLL 549

  Fly   524 RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFS 588
            |:..| ...:|:.::||...:|..:....:.|.:.:::|      .|.|| |.::..:....  :
  Rat   550 RRAEK-TVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PRLQMGSMTST--T 604

  Fly   589 FANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDAD 653
            ..|.:||..|:.:|||.|:.....:||.:..:||.|.||::||||||||||||:..:.:.|....
  Rat   605 LYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQ 669

  Fly   654 DLSKNKGGVNYGAKIGGATFN---------FFKESNYPTYQRMYEFMRDN-PQYMTNTNQEGVDR 708
            |||| :..:.||..:..|.:.         |.::|.|....||..  |.| .:.....:|.|:.:
  Rat   670 DLSK-QTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMIN--RSNGSENNVLESQAGIQK 731

  Fly   709 VENSNYAFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGL 771
            |:..||||:.::..:||  |.:..|:...||..:.::|||||::...||||..||.:||:|:.|.
  Rat   732 VKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGD 796

  Fly   772 LTKMKTKWWQEKRGGGACS-----DADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG 831
            :..:|.|||.:   .|.|.     ||.:..|  ||:|.:|.|||.::..|......:::||....
  Rat   797 MDILKHKWWPK---NGQCDLYSSVDAKQKGG--ALDIKSLAGVFCILAAGIVLSCLIAVLETWWS 856

  Fly   832 ------VKERSDENQVSFK 844
                  |..:.|:.::..:
  Rat   857 RRKGSRVPSKEDDKEIDLE 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	91/419 (22%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	129/382 (34%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		70/349 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	92/421 (22%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	130/385 (34%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007