Protein Alignment Grik and grin1

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_012825220.1
• Gene: grin1 / 780048
• XenbaseID: XB-GENE-494200
• Length: 941
• Species: Xenopus tropicalis
• Alignment Length: 1005
• Identity: 236/1005 - (23%)
• Similarity: 417/1005 - (41%)
• Gaps: 198/1005 - (19%)

  Fly    17 FILTSLLL---AFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENE--DLQLHGVSVSIEP 76
            |:|..|.|   |..||..:..|:|.|......  |:||..|:::||:.:.  .:||:..||:..|
 Frog     7 FLLAVLFLFSFARAGCDPKIVNIGAVLSTKKH--EQIFREAVNQANKRHGTWKIQLNATSVTHRP 69

  Fly    77 GNSFETSKKLCK-MLRQNLVAVF-----GPTSNLAARHAMSICDAKELPF--LDTRWDFGAQ--- 130
             |:.:.:..:|: ::...:.|:.     .||.:|.............:|.  |.||....:.
 Frog    70 -NAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSI 133

  Fly   131 ----LPTINLHPHPATLGVALRDMVVALGWESFTII----------------------------- 162
                |.|:..:.|.|.:..   :|:....|....:|
 Frog   134 HLSFLRTVPPYSHQALVWF---EMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKSKKRN 195

  Fly   163 YESGEYL-------PTVRELLQMY-GTAGPT-VTVRRYELDLNGNYRNVLRRIRNADDFSFVVVG 218
            ||:.:.|       |...::||.. ||...| :.:...||:     ..|:....:.||.:.|
 Frog   196 YENLDQLSYDNKRGPKADKVLQFEPGTKNLTALLLEAKELE-----ARVIILSASEDDATAV--- 252

  Fly   219 SMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKA 283
                    :|.|..:.:..:.|.:::|..:   :.....::|...|.||:|::.
 Frog   253 --------YKSAAMLDMTGAGYVWLVGERE---ISGSALRYAPDGIIGLQLING----------- 295

  Fly   284 LYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSC-NDDSAWDKGYTLVN-YMKS 346
                    :|.|..:::::|:   ..|.:.|.::..|.......| .:.:.|..|..... .|.|
 Frog   296 --------KNESAHISDAVAV---AAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSS 349

  Fly   347 LTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPA--PAHSLEPDMRSL 409
            ...:|:||.|.|:.:|.|......::.|....:.::|.::|....|.:|..  |....|......
 Frog   350 KYPDGVTGRIEFNEDGDRKFANYSIMNLQNRKLVQVGIFNGSHVIQNDRKIIWPGGETERPQGYQ 414

  Fly   410 VNKSFVVITAISEPYGMLKET-------------------------SEKLEGNDQFE----GFGI 445
            ::....::|...||:..:|.|                         :|.:.|.....    ||.|
 Frog   415 MSTRLKIVTIHQEPFVYVKPTMTDGTCREEYTINGDPIKKVICNGPNETIPGRPTVPQCCYGFCI 479

  Fly   446 ELIDELSKKLGFSYTWRLQEDNKYGGID----PKTGEWNGMLREIIDSRADMGITDLTMTSERES 506
            :|:.:|::::.|:|...|..|.|:|..:    ....|||||:.|::..:|||.:..||:.:||..
 Frog   480 DLLIKLAREMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 544

  Fly   507 GVDFTIPFMSLGIGILFRKPMKEPPK--LFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAE 569
            .::|:.||...|:.||.:   ||.|:  |.|||.||...:||.:||:...|::.:::|.|.||..
 Frog   545 YIEFSKPFKYQGLTILVK---KEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFG 606

  Fly   570 WDNPYPCIEEPTELENQFSFANCLWFSIGALLQQG-SELAPKAYSTRAVAASWWFFTLILVSSYT 633
            ...    :....|.|:..:.::.:|||.|.||..| .|.||:::|.|.:...|..|.:|:|:|||
 Frog   607 RFK----VNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYT 667

  Fly   634 ANLAAFLTV---ESLVTPINDADDLSKNKGGVNYGAKIGGATFNFF----KESNYPTYQR----- 686
            |||||||.:   |..:|.|||              .::...:..|.    |:|:...|.|
 Frog   668 ANLAAFLVLDRPEERITGIND--------------PRLRNPSDKFIYATVKQSSVDIYFRRQVEL 718

  Fly   687 --MYEFMRDNPQYMTNTNQEGVDRV-ENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIA 748
              ||..|.   ::...:..|.:..| :|..:||:.:|..:|:...::|.|...|.|....|:||.
 Frog   719 STMYRHME---KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIG 780

  Fly   749 MRKNWPYRDTLSQAVLEMQEQGLLTKMKTKW--WQEKRGGGACSDADEDSGAVA-LEISNLGGVF 810
            |||:.|::..:|..:|:..|.|.:.::...|  :||         .|..|.|.| |...|:.|||
 Frog   781 MRKDSPWKQNVSLNILKSHENGFMEELDKTWVRYQE---------CDSRSNAPATLTFENMAGVF 836

  Fly   811 LVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNA 875
            :::..|...|||:..:|:.....:.:...|:......::..|..||...:.:|...||..:...:
 Frog   837 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKASFRS 901

  Fly   876 SSKSKGSSMSVDSLPEDTS--EADASGKHN 903
            .:.:..||.......:||.  ..|.:|:.|
 Frog   902 ITSTLASSFKRRRSSKDTQYHPTDITGQLN 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	77/416 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	119/422 (28%)
grin1	XP_012825220.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	78/425 (18%)
		PBP2_iGluR_NMDA_Nr1	416..818	CDD:270437	121/434 (28%)
		CaM_bdg_C0	854..882	CDD:402271	2/27 (7%)