Protein Alignment Grik and grin2ab

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_073805448.1
• Gene: grin2ab / 570493
• ZFINID: ZDB-GENE-070424-223
• Length: 1445
• Species: Danio rerio
• Alignment Length: 882
• Identity: 191/882 - (21%)
• Similarity: 358/882 - (40%)
• Gaps: 228/882 - (25%)

  Fly    64 DLQLHGVSVS-IEPGNSFETSKKLCKML-RQNLVA-VFGPTSNLAARHAMSICDAKELPFLDTRW 125
            |:.:..:.|: .:||:..   ..||::: ||.|.. |:|..::..|       .|:.|.|:.::
Zfish    55 DVTVLSIQVNQTDPGSML---THLCELMSRQRLHGLVYGDGTDQEA-------VAQMLDFVSSQ- 108

  Fly   126 DFGAQLPTINLHPHPA-------------TLGVALRD---MVVAL----GWESFTIIYES----G 166
               ..:|.:.:|...|             ..|.:|:.   :::|:    .|..|:::...    .
Zfish   109 ---TSMPILGIHGGSAMTMAEKDSSSSFFQFGASLQQEALLMLAIMEEYDWHVFSVVTTKFPGFQ 170

  Fly   167 EYLPTVRELLQMYGTAGPTVTVR----RYELD----LNG-----NYRNV-LRRIR--------NA 209
            |::.|||            |||.    |::|.    |:|     :..:| |:||:        :.
Zfish   171 EFIATVR------------VTVDHSFVRWDLQSVVTLDGVGEPEDRAHVQLKRIQSPVILLYCSK 223

  Fly   210 DDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYII-----GNLDWHTMDLEPYQHAGTNITGLRL 269
            |:.:.|:           ::|:.:||..:.:.:|:     |||: |..:..|        .|:..
Zfish   224 DEAALVM-----------EEARSLGLTGAGFVWIVPSLTTGNLE-HIPEAFP--------AGMIS 268

  Fly   270 VSPDSEQVQEVAKALYESEEPFQNVSCPLTNSMALVY-------DGVQLLAETYKHVNFRPVALS 327
            |:.|...        |..|...|:....::::.|.::       ||........:.....|.||.
Zfish   269 VTYDEWD--------YPLETRLQDAVGIISSAAAAMFREEGRIPDGTASCYGQSEKPEVPPSALR 325

  Fly   328 CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVS-GMQKIGQWSGEDGF 391
                          .||..:.|.|...  .|..:|.:.:.||.||.|... ..:|:|:|
Zfish   326 --------------RYMMGVNLGGKDH--SFMDDGYQVNPKLVVIVLNTEREWEKMGRW------ 368

  Fly   392 QENRPA-------PAHSLEPDMR---------SLVNKSFVVITAISEPYGMLKETS--------- 431
             ||...       |.::...||.         :|..:.||::..:....|.....|
Zfish   369 -ENHSLRLKFPVWPRYNSFGDMDADENHLSIVTLEERPFVIVDDVDILTGTCMRNSVPCRKHIKD 432

  Fly   432 EKLEGN---DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADM 493
            ...||:   ...:||.|:::.::::.:.|:|...|..:.|:|  ......||||:.|::..:|.|
Zfish   433 NTTEGSYVKKCCKGFCIDILKKIARNVKFTYDLYLVTNGKHG--KKINNVWNGMVGEVVYKKAVM 495

  Fly   494 GITDLTMTSERESGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGV-S 556
            .:..||:..||...:||::||:..||.::. |......|.  :|:.|||..||:.:.:..:.| :
Zfish   496 AVGSLTINEERSEAIDFSVPFVETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVTA 558

  Fly   557 ISMFVLGRLSP-------AEWDNPY-PCIEEPTELENQFSFANCLWFSIGALLQQGSELA-PKAY 612
            |::|:...:||       |:..:|: |          .|:....:|...|.:......:. |:..
Zfish   559 IAVFLFEFISPLGFNRNLAQGKDPHGP----------SFTIGKAVWLLWGLVFNNSVPVQNPRGT 613

  Fly   613 STRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNY------GAKIGGA 671
            :::.:.:.|.||.:|.::|||||||||:..|..|..:....| .|.:...:|      |....|:
Zfish   614 TSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSD-RKFQSPYSYSPPFRFGTVPNGS 677

  Fly   672 TFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEG-VDRVENSNY----AFLMESTTIEYITER-- 729
            |....:: |||...          |||...:|.| ||.:.:...    ||:.::..:.|:..|
Zfish   678 TERNIRK-NYPAMH----------QYMVKYHQTGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDD 731

  Fly   730 RCTLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDA 792
            .|.|..:|:  :....||||||:|...::..:..|:|.:...|.:.:::.:|..     |.|.:.
Zfish   732 GCKLVTIGSGYIFATTGYGIAMQKGSYWKRLVDLAILGIIGDGEMEELEAQWLT-----GICHNE 791

  Fly   793 DEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMV 829
            ..:..:..|::.|:.|||.::..    .:.:||:..|
Zfish   792 KNEVMSSQLDVDNMAGVFYMLAA----AMALSLITFV 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	76/392 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	100/407 (25%)
grin2ab	XP_073805448.1	None