DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and grin3ba

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	979	Identity:	225/979 - (22%)
Similarity:	375/979 - (38%)	Gaps:	245/979 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 NTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAA 106
            |.||  |.:|....       :|:.:.|||..:    :|..|       .:.|:.|...:|.|
Zfish    92 NGDP--ESMFRCVC-------QDIVVQGVSAVL----AFPQS-------HEELIQVEFMSSFL-- 134

  Fly   107 RHAMSICDAKELPF---------LDTRWDFGAQLPTINLHPHPATLGVALRDMVVAL----GWES 158
                      |:||         |.|:..|..|:.| .:.|.      .|.|:::|:    ||:.
Zfish   135 ----------EIPFISIIEQGEPLKTQNRFHLQMMT-RMPPS------GLSDLLLAVLLRGGWQG 182

  Fly   159 FTIIYESGEYLPTVRELLQMYGTAG---------PTVTVRRYELDLNGN-----YRNVLRRIRNA 209
            .......|.....:.|.||..|..|         .|:.:.|.|.:::.:     ...:|.|..:|
Zfish   183 GAATVCPGGGNTGMLEELQQRGHLGLDGAHWHLWETLNLSRLEENISEDKVMELLSQLLSRTPSA 247

  Fly   210 DDFSFVVVGS----MATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLV 270
            ...|.|:.||    .||:   ...|.|:........:|:|    :.:.|:.....|:.: ||...
Zfish   248 PASSVVLFGSDPECTATV---LHCAHQLSGTLPPMHWIMG----YPLSLDSLHSIGSPL-GLMAY 304

  Fly   271 SPDSEQVQEVAKALYESEEPFQNVSCPLTNSMALVYDGVQLLAE-TYKHVNFRP-VALSCNDDSA 333
            .       ||.:.             ||.   ..:.|.:||:.. .|.....|| :||..|..:.
Zfish   305 G-------EVNRK-------------PLN---FYIRDTLQLIGRAVYAATMVRPDLALIQNMVNC 346

  Fly   334 WDK---------GYTLVNYMKSLTLNGLTGPIRFD--YEGLRTDFKLEVIELA------------ 375
            :||         |..|..::.:.:..|||||:|.:  :..:.|..:..:..|.
Zfish   347 FDKPNKHELPSSGQYLARFLSNTSFTGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTV 411

  Fly   376 ---VSG---MQKIGQWSG------EDG--------FQENRPAPAHSLEPDMRSLVNKSFVVITAI 420
               .||   :::.|.|.|      |||        :|...|.....|.  :.:||...||....:
Zfish   412 ASWQSGRLELEEQGLWPGVTQHQREDGPGIRLGGRWQAGLPVAGSRLR--VVTLVEHPFVFTREV 474

  Fly   421 SE----PYGML-----KETSEKLEGNDQFE-------------------GFGIELIDELSKKLGF 457
            .|    |.|.|     ...||.|  |..|.                   |:.|:|:::|::.:.|
Zfish   475 DEEGQCPAGQLCLDPQTNNSEVL--NQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHF 537

  Fly   458 SYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGIL 522
            .:...:..|.|||..  |.|.|:|::.:::...|||.:|..::.|.|...:|||.||.|..:|||
Zfish   538 EFDLYIVGDGKYGAW--KGGRWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGIL 600

  Fly   523 FRKPMKEPPKLFSFMSPFSGEVW--LWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELEN 585
            .|......| :.:||.|....:|  :::.|....:.|:::        ||::|:...........
Zfish   601 VRSKDTAAP-IGAFMWPLHWSMWVGIFVALHITALFITLY--------EWNSPFGMTPHGRNRIR 656

  Fly   586 QFSFANCLWFSIGALLQQGSELA---PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVT 647
            .||:::.|......|.  |..:|   ||.::.|.:...|..|.|:::|||||||||.:..|....
Zfish   657 VFSYSSALNLCYAILF--GRTVASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFE 719

  Fly   648 PINDADDLSKNKG--GVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVE 710
            .::...|:..:..  |..:|.....:..::.|:|    :..|:|:||   ::...|..:||..::
Zfish   720 EVSGIHDVKLHHPSLGFRFGTVRESSAEDYVKKS----FPEMHEYMR---RFNKPTTPDGVSTLK 777

  Fly   711 NSN---YAFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQG 770
            ...   .||:|:...::|  ..:..|.|..||.....:||||.:.:|.|....:|:.|...:..|
Zfish   778 TDPPQLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTRNVSEYVSRYKSDG 842

  Fly   771 LLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKER 835
            .:..:..||::....|.......|.               |.||:..|.|:||.|...|.|.
Zfish   843 YMDMLHDKWYKVVPCGKRVFAVTET---------------LQMGIQHFSGLFVLLCVGVAGA--- 889

  Fly   836 SDENQVSFKTELLDE---IRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSEAD 897
                    ...||.|   .||||....:.:..||..::|:    ...:..:|..|.  |..|||:
Zfish   890 --------LLTLLGEHAFFRFILPHLRHQQRFKYWLHTSQ----KIHRAINMGCDD--ERKSEAE 940

  Fly   898 ASGK 901
            :|.:
Zfish   941 SSDR 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	88/424 (21%)
		ANF_receptor	53..374	CDD:279440	74/364 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	103/409 (25%)
		Lig_chan	543..816	CDD:278489	64/284 (23%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	83/405 (20%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	105/418 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840