DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and grik1b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	900	Identity:	332/900 - (36%)
Similarity:	508/900 - (56%)	Gaps:	91/900 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGFILTSLLLAFPGCRGERT-NVGLVY---ENTDPDLEKI-FHLAISKANEENEDLQLHGVSVSI 74
            :.|||. .|:|..|...::. .:|.::   ||....:|:: |..|::..|.....:....::..|
Zfish    45 VSFILL-CLMAEVGLSAQQVLRIGGIFETLENEPISVEELAFKFAVTNINRNRTLMPNTTLTYDI 108

  Fly    75 EPGN---SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPT--- 133
            :..|   |||.|::.|..|...:.|||||:.:.:.....|||:|.|:|.:.|||    :.|:
Zfish   109 QRINLFDSFEASRRACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRW----KHPSVDN 169

  Fly   134 -----INLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYEL 193
                 |||:|..|::..|:.|:|....|::.|::||....|..::||::     .|:    ||.:
Zfish   170 KDSFYINLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGLIRLQELIK-----APS----RYSI 225

  Fly   194 DL--------NGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWH 250
            .:        :.:.|.:|:.::...:|..:...|..|..:..||...:|::|..|.:....||.:
Zfish   226 KIKIRQLPTGSKDARPLLKEMKKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLY 290

  Fly   251 TMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCP--------LTNSMALVYD 307
            ::||||::::|.|:||.||::.|:.||..|.:..  |.|..|....|        :|...||:||
Zfish   291 SLDLEPFRYSGVNMTGFRLLNIDNPQVASVVEKW--SMERLQAPPKPETGLQDGMMTTEAALMYD 353

  Fly   308 GVQLLAETYKHVNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLE 370
            .|.::|...:..:...| :|.|:....|..|...::..|....|||||.|..: .:|||.||.|:
Zfish   354 AVYMVAAASQRASQITVSSLQCHRHKPWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKDFDLD 418

  Fly   371 VIELAVSGMQ-------------KIGQWSGEDGF---QENRPAPAHSLEPDMRSLVNKSFVVITA 419
            :|.|...|::             |||.|:...|.   ..|:....:..:    |:.|::.:|.|.
Zfish   419 IISLKEDGLEKPLESGRFNKVWKKIGVWNSNTGLNLTDSNKDKNTNVTD----SMANRTLIVTTI 479

  Fly   420 ISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLR 484
            :..||.|.|::.:.|.|||:|||:.::|:.|||..|||||..:|..|.|||..:.| ||||||:|
Zfish   480 LENPYVMYKKSDKPLYGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYGAQNDK-GEWNGMVR 543

  Fly   485 EIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLG 549
            |:||..||:.:..||:|..||..:||:.|||:|||.||:.||....|.:|||::|.|.::|:::.
Zfish   544 ELIDHVADLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVL 608

  Fly   550 LAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYST 614
            ||.:|||..:||:.|.:|.||.||:||..:...:||.|:..|.:||.:|||:||||||.|||.||
Zfish   609 LACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALST 673

  Fly   615 RAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKES 679
            |.|...|||||||::||||||||||||||.:.:||:.||||:| :..:.|||...|:|..|||:|
Zfish   674 RIVGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAK-QTKIEYGAVRDGSTMTFFKKS 737

  Fly   680 NYPTYQRMYEFM--RDNPQYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDE 742
            ...||::|:.||  |.|...:.| |:||:.||..::||.|||||:||||::|.|.|||:|.|:|.
Zfish   738 KISTYEKMWAFMSSRKNTALVKN-NREGIQRVLTTDYALLMESTSIEYISQRNCNLTQIGGLIDS 801

  Fly   743 KGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLG 807
            ||||:......||||.::.|:|::||:|.|..||.|||   ||.| |.:.|... |.||.:.|:|
Zfish   802 KGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWW---RGNG-CPEEDSKE-ASALGVENIG 861

  Fly   808 GVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTK 862
            |:|:|:..|....:||::.|.:...::..|..:||           :.||..:.|
Zfish   862 GIFIVLAAGLVLSVFVAIGEFIYKSRKNLDIEEVS-----------VGQCEWHNK 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	110/399 (28%)
		ANF_receptor	53..374	CDD:279440	99/349 (28%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	189/371 (51%)
		Lig_chan	543..816	CDD:278489	139/274 (51%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	111/407 (27%)
		ANF_receptor	80..423	CDD:279440	101/357 (28%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	190/374 (51%)
		Lig_chan	602..871	CDD:278489	139/275 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760